New insight into oxidative stress and inflammatory responses to kidney stones: Potential therapeutic strategies with natural active ingredients

Background Kidney stone disease (KSD) occurs in a wide range of ages and is influenced by multiple factors. Early detection and elimination of risk factors for KSD can effectively reduce the incidence of KSD. Methods In this research, we included KSD participants from the National Health and Nutrition Examination Survey (NHANES) database from 2007 to 2015. Baseline characteristics of the participants were investigated using Student's t-tests and chi-square tests. Subsequently, the relationship between high intensity activities (HIA) and KSD was investigated through multifactor glm regression modeling. In addition, the linear relationship between them was explored by smoothing curves. Finally, the predictive performance of HIA on KSD was explored based on receiver operating characteristic (ROC) curves. Results At first, 6,642 subjects were finally recruited for this study. The baseline statistical table showed that the exposure factor (time spent in HIA) was chosen to have a significant differentiation for KSD. In addition, HIA was significantly associated with KSD in all three models, with OR greater than 1 and P < 0.05. The smoothed curves showed that short periods of HIA did not increase the risk of KSD, but over a certain period of time greatly increased the risk of KSD. Stratified analysis results showed that exposure factors and race, educational status, and gout were significantly associated with KSD in Model 3. Eventually, ROC curve indicated the prediction for HIA to KSD was relatively accurate. Conclusion This study revealed a link between HIA and KSD, with HIA over a certain period of time greatly increasing the risk of KSD.

show abstract

Traditional Plants Based Treatment for Kidney Stones: Insight into Herbal Drugs

Shruti,

Rani,

Singh

et al. 2024

J. Drug Delivery Ther.

View full text Add to dashboard Cite

The deposition of hard crystals created by mineral or salt buildup in the urine canal leads to kidney stones, a frequent urinary tract issue. Urine flow obstruction and excruciating discomfort can be caused by kidney stones. Numerous processes can lead to oxidative stress, which raises the probability of kidney stones developing. The inflammatory response that results from kidney stones forming exacerbates oxidative stress further, creating a vicious cycle. This urological condition, which affects both male and female populations, is becoming more widespread worldwide. Planning the volume of urine produced is a crucial stage in the elimination of kidney stones. Surgery such as shock wave lithotripsy (SWL) and ureteroscopy (URS) is used to treat conditions when the stone has ceased passing through and is causing excruciating discomfort. Because of their medicinal and antioxidant properties, as well as their active substances, medicinal plants have positive benefits on human health. Regrettably, end-stage renal disease is frequently the consequence of side effects brought on the traditional medications used to treat nephrolithiasis. Kidney stones can be avoided by controlling nutrition intake, medication usage, and diet. Agents that are urolithotriptic are medicinal herbs. Examining the natural plants that are utilized to treat the illness is the goal of this review. Finding natural plants that can be used to cure kidney stones was made easier by this review. Keywords: Kidney stones, Urolithiasis, diuresis, herbal drug, calcium oxalate stone

show abstract

New insight into oxidative stress and inflammatory responses to kidney stones: Potential therapeutic strategies with natural active ingredients

Cited by 3 publications

References 117 publications

The association of glyphosate exposure with kidney stones in American adults: A nationally representative cross-sectional study

The association of glyphosate exposure with kidney stones in American adults: A nationally representative cross-sectional study

The relationship between high intensity activities and kidney stone: A cross-sectional survey of NHANES

Traditional Plants Based Treatment for Kidney Stones: Insight into Herbal Drugs

Contact Info

Product

Resources

About