New insights and options into the mechanisms and effects of combined targeted therapy and immunotherapy in prostate cancer

Lin, Min; Sun, Xue

doi:10.1016/j.omto.2023.04.007

Cited by 5 publications

(2 citation statements)

References 174 publications

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“…Another limitation of immunotherapy pertains to the potential occurrence of side effects ( 144 ). Although immunotherapy generally exhibits lower toxicity compared to traditional cancer treatments, it can still induce immune-related side effects such as inflammation, fatigue, and cutaneous manifestations ( 144 , 145 ). In certain instances, these side effects may severely manifest and urgently demand intervention.…”

Section: Future Perspectivesmentioning

confidence: 99%

Harnessing the power of traditional Chinese medicine monomers and compound prescriptions to boost cancer immunotherapy

Miao,

Liu,

et al. 2023

Front. Immunol.

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At present, cancer is the largest culprit that endangers human health. The current treatment options for cancer mainly include surgical resection, adjuvant radiotherapy and chemotherapy, but their therapeutic effects and long-term prognosis are unsatisfactory. Immunotherapy is an emerging therapy that has completely transformed the therapeutic landscape of advanced cancers, and has tried to occupy a place in the neoadjuvant therapy of resectable tumors. However, not all patients respond to immunotherapy due to the immunological and molecular features of the tumors. Traditional Chinese Medicine (TCM) provides a new perspective for cancer treatment and is considered to have the potential as promising anti-tumor drugs considering its immunoregulatory properties. This review concludes commonly used TCM monomers and compounds from the perspective of immune regulatory pathways, aiming to clearly introduce the basic mechanisms of TCM in boosting cancer immunotherapy and mechanisms of several common TCM. In addition, we also summarized closed and ongoing trials and presented prospects for future development. Due to the significant role of immunotherapy in the treatment of non-small cell lung cancer (NSCLC), TCM combined with immunotherapy should be emphasized in NSCLC.

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Section: Future Perspectivesmentioning

confidence: 99%

Harnessing the power of traditional Chinese medicine monomers and compound prescriptions to boost cancer immunotherapy

Miao,

Liu,

et al. 2023

Front. Immunol.

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“…Since the approval of the first immunotherapy sipuleucel-T in treating metastatic castration-resistant prostate cancer in 2010, the past decade has witnessed a surge in immunotherapy trials in prostate cancer. The major immunotherapy approaches that have been tested encompass immune checkpoint inhibitors, bispecific T cell-engaging antibodies, adoptive cell therapy utilizing gene-modified T cells directed against cancer, and therapeutic vaccines priming tumor-specific immunity [ 14 , 15 ]. In this review, we will delve into the emerging immunotherapy approaches for prostate cancer, as illustrated in Figure 1 .…”

Section: Introductionmentioning

confidence: 99%

Emerging Immunotherapy Approaches for Treating Prostate Cancer

Meng,

Yang,

Mortazavi

et al. 2023

IJMS

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Immunotherapy has emerged as an important approach for cancer treatment, but its clinical efficacy has been limited in prostate cancer compared to other malignancies. This review summarizes key immunotherapy strategies under evaluation for prostate cancer, including immune checkpoint inhibitors, bispecific T cell-engaging antibodies, chimeric antigen receptor (CAR) T cells, therapeutic vaccines, and cytokines. For each modality, the rationale stemming from preclinical studies is discussed along with outcomes from completed clinical trials and strategies to improve clinical efficacy that are being tested in ongoing clinical trials. Imperative endeavors include biomarker discovery for patient selection, deciphering resistance mechanisms, refining cellular therapies such as CAR T cells, and early-stage intervention were reviewed. These ongoing efforts instill optimism that immunotherapy may eventually deliver significant clinical benefits and expand treatment options for patients with advanced prostate cancer.

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Genomic Discoveries: Precision Medicine and Personalized Approaches in Prostate Cancer Care

Bida,

Mosoane,

Nonxuba

et al. 2024

Transforming Prostate Cancer Care

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New insights and options into the mechanisms and effects of combined targeted therapy and immunotherapy in prostate cancer

Cited by 5 publications

References 174 publications

Harnessing the power of traditional Chinese medicine monomers and compound prescriptions to boost cancer immunotherapy

Harnessing the power of traditional Chinese medicine monomers and compound prescriptions to boost cancer immunotherapy

Emerging Immunotherapy Approaches for Treating Prostate Cancer

Genomic Discoveries: Precision Medicine and Personalized Approaches in Prostate Cancer Care

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