New Insights in Therapy for Food Allergy

Mayorga, Cristobalina; Palomares, Francisca; Cañas, J. A.; Pérez‐Sánchez, Natalia; Núñez, Rafael; Torres, Marı́a José; Gómez, Francisca

doi:10.3390/foods10051037

Cited by 24 publications

(21 citation statements)

References 135 publications

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“…The highest amount of Pru p 3 can be found in the peach peel with a content seven times higher than in the pulp 10,11 . In line with this, peach allergy itself is described as common cause of fresh-fruit allergy 10 .Currently, the main treatment options for peach allergy and food allergies in general are allergen avoidance or symptomatic treatment including anti-histamines as to date no cure or preventive treatment is available [12][13][14] . Due to this lack of treatment options, oral immunotherapy (OIT) might be considered an attractive option to induce immunological tolerance by administration of increasing dosages of allergen.…”

mentioning

confidence: 99%

“…Currently, the main treatment options for peach allergy and food allergies in general are allergen avoidance or symptomatic treatment including anti-histamines as to date no cure or preventive treatment is available [12][13][14] . Due to this lack of treatment options, oral immunotherapy (OIT) might be considered an attractive option to induce immunological tolerance by administration of increasing dosages of allergen.…”

mentioning

confidence: 99%

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Peach extract induces systemic and local immune responses in an experimental food allergy model

Steigerwald

Krause

González-Menéndez

et al. 2023

Sci Rep

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Peach allergy is among the most frequent food allergies in the Mediterranean area, often eliciting severe anaphylactic reactions in patients. Due to the risk of severe symptoms, studies in humans are limited, leading to a lack of therapeutic options. This study aimed to develop a peach allergy mouse model as a tool to better understand the pathomechanism and to allow preclinical investigations on the development of optimized strategies for immunotherapy. CBA/J mice were sensitized intraperitoneally with peach extract or PBS, using alum as adjuvant. Afterwards, extract was administered intragastrically to involve the intestinal tract. Allergen provocation was performed via intraperitoneal injection of extract, measuring drop of body temperature as main read out of anaphylaxis. The model induced allergy-related symptoms in mice, including decrease of body temperature. Antibody levels in serum and intestinal homogenates revealed a Th2 response with increased levels of mMCPT-1, peach- and Pru p 3-specific IgE, IgG1 and IgG2a as well as increased levels of IL-4 and IL-13. FACS analysis of small intestine lamina propria revealed increased amounts of T cells, neutrophils and DCs in peach allergic mice. These data suggest the successful establishment of a peach allergy mouse model, inducing systemic as well as local gastrointestinal reactions.

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confidence: 99%

mentioning

confidence: 99%

Peach extract induces systemic and local immune responses in an experimental food allergy model

Steigerwald

Krause

González-Menéndez

et al. 2023

Sci Rep

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“…Second, because of the lack of understanding of the pathogenic mechanisms of food allergy, there is a lack of safe and effective treatment options for individuals diagnosed with food allergy. The only safe and effective method for patients with a food allergy diagnosis is to strictly avoid the allergic antigens (11,12). However, there is widespread concern that a strict and limited diet in patients with food allergies can lead to nutritional deficiencies and growth failure in children (13).…”

Section: Introductionmentioning

confidence: 99%

Intestinal Uptake and Tolerance to Food Antigens

Xiong

Chen

et al. 2022

Front. Immunol.

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Food allergy is a growing concern due to its increasing world-wide incidence. Strict avoidance of allergens is a passive treatment strategy. Since the mechanisms responsible for the occurrence and development of food allergy have not yet been fully elucidated, effective individualized treatment options are lacking. In this review, we summarize the pathways through which food antigens enter the intestine and review the proposed mechanisms describing how the intestine acquires and tolerates food antigens. When oral tolerance is not established, food allergy occurs. In addition, we also discuss the contribution of commensal bacteria of the gut in shaping tolerance to food antigens in the intestinal tract. Finally, we propose that elucidating the mechanisms of intestinal uptake and tolerance of food antigens will provide additional clues for potential treatment options for food allergy.

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“…Development of FA can be related to some concepts such as the influence of genetic, epigenetic, environmental, and nutritional factors [2], which seem to be involved in its etiology. Genetic studies have shown that there are hundreds of genes in FA that are associated with food-specific IgE, providing strong evidence that genome can determine the complex trait of IgE-mediated FA [3].…”

Section: Introductionmentioning

confidence: 99%

Epigenetics in Food Allergy and Immunomodulation

et al. 2021

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Food allergy (FA) is an increasing problem worldwide and, over recent years, its prevalence is rising in developed countries. Nowadays, the immunological and cellular processes that occur in the allergic reactions are not fully understood, which hampers the development of in vitro diagnostic tools and further treatment options. Moreover, allergic diseases could be reinforced by environmental exposure and genetic modifications. Gene expression can be controlled by different epigenetic mechanisms like DNA methylation, histone modifications, and microRNAs. In addition, several environmental factors such as dietary components (vitamin D, butyrate, folic acid) are able to regulate this epigenetic mechanism. All these factors produce modifications in immune genes that could alter the development and function of immune cells, and therefore the etiology of the disease. Furthermore, these epigenetic mechanisms have also an influence on immunomodulation, which could explain sustained responsiveness or unresponsiveness during immunotherapy due to epigenetic modifications in key genes that induce tolerance in several FA. Thus, in this review we focus on the different epigenetic mechanisms that occur in FA and on the influence of several dietary components in these gene modifications.

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New Insights in Therapy for Food Allergy

Cited by 24 publications

References 135 publications

Peach extract induces systemic and local immune responses in an experimental food allergy model

Peach extract induces systemic and local immune responses in an experimental food allergy model

Intestinal Uptake and Tolerance to Food Antigens

Epigenetics in Food Allergy and Immunomodulation

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