New Insights into Bioactive Compounds from the Medicinal Plant Spathodea campanulata P. Beauv. and Their Activity against Helicobacter pylori

Ngnameko, Corinne Raïssa; Marchetti, Lucia; Zambelli, Barbara; Quotadamo, Antonio; Roncarati, Davide; Bertelli, Davide; Njayou, Fréderic Nico; Smith, Stella I.; Moundipa, Paul Fewou; Costi, Maria Paola; Pellati, Federica

doi:10.3390/antibiotics9050258

Cited by 8 publications

(8 citation statements)

References 34 publications

(46 reference statements)

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“…The leaf is also used to treat epilepsy (Noumi and Fozi, 2003), liver disorder (Shiracko et al, 2016), asthma (Nwauzoma and Dappa, 2013), measles (Oladunmoye et al, 2011), and sore throat (Shiracko et al, 2016). The root is used for worm infections (Musinguzi et al, 2017), stomach ache (Musinguzi et al, 2017), dysentery (Tabuti et al, 2003), and hallucination (Ior et al, 2017). The flower is used as an antidote against animal poison (Santosh et al, 2019) and cataract (Tewari et al, 2019).…”

Section: Ethnomedicinal Usementioning

confidence: 99%

“…Specioside (8) has been detected in the flower of the plant (Elusiyan et al, 2011). Phytochemical analysis of leaves and stem bark (Ngouela et al, 1988(Ngouela et al, , 1990(Ngouela et al, , 1991 revealed the presence of different triterpenoids, viz. spathodic acid (9), 3β-acetoxyoleanolic acid (10), siaresinolic acid (11), 3β-acetoxy-12-hydroxyoleanan-28,13-olide, and oleanolic acid (16).…”

Section: Phytochemical Studiesmentioning

confidence: 99%

“…Another sub-fraction had modulated the expression of one cytotoxin (CagA) and two adhesions (HopZ and BabA). Kaempferol (42) was identified as an active compound from the sub-fraction (Ngnameko et al, 2020).…”

Section: Antibacterial and Antifungal Activitymentioning

confidence: 99%

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Spathodea campanulata P. Beauv. —A review of its ethnomedicinal, phytochemical, and pharmacological profile

Padhy¹

2021

J Appl Pharm Sci

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Spathodea campanulata P. Beauv., belonging to the family Bignoniaceae, is a big erect tree with an ancient history of medicinal use in Africa. In the traditional system, it is mentioned for the treatment of malaria, diabetes, stomach ulcers, wounds, skin infections and viral diseases. The aim of the review is to make available the current information that exists on the traditional uses, phytochemistry, pharmacology, and toxicology of S. campanulata. Additionally, the potential uses of this plant to treat various diseases and to bring in a foundation for further research are emphasized. The present review is carried out by compiling literature from 1972 to 2021, concerning the morphology, traditional uses, phytochemistry, pharmacological activities, and toxicological aspects of S. campanulata. Literatures were collected from various online search engines, viz. Google Scholar, PubMed, Science Direct, Core, and Semantic Scholar. Diverse chemical compounds including iridoids, terpenoids, steroids, cinnamic acid derivatives, cerebrosides, flavonoids, and carotenoids have been isolated from this plant. Mostly in-vivo models have indicated several evidences of the use of this plant particularly to cure malaria. Few in-vivo studies have also proved the usefulness of this plant in inflammation, wound healing, diabetes, and convulsion. In some in-vitro studies, the anticancer, antibacterial, antiviral insecticidal, larvicidal, and anti-oxidant potential has been proved. Preclinical studies have demonstrated remarkable activity which supports the conventional use of the plant as an antimalarial, wound healing, antidiabetic, antimicrobial, and anti-inflammatory agent for years without any adverse effects. Based on the results obtained from a combination of in vivo and in vitro potency and toxicity studies reported, S. campanulata is a promising agent in the development of nutraceuticals against malaria and diabetes. Although few phytochemicals isolated (ursolic acid, tomentosolic acid, 20β-hydroxyursolic acid, verminoside, specioside, spathoside, kaempferol, and β-sitosterol-3-acetate) from the plant exhibited remarkable biological activity, it was only confined to preclinical study. The only clinical study documented is for curing malaria, but with crude extract only. With its current extensive traditional use, there is a need for additional studies of the isolated compounds, clinical trials, and product development to take full advantage of this widely distributed medicinal plant.

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Section: Ethnomedicinal Usementioning

confidence: 99%

Section: Phytochemical Studiesmentioning

confidence: 99%

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Spathodea campanulata P. Beauv. —A review of its ethnomedicinal, phytochemical, and pharmacological profile

Padhy¹

2021

J Appl Pharm Sci

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“…Due to its ethnobotanical uses, the plant has been the subject of many phytochemical and pharmacological studies. The presence of several bioactive compounds has been reported, including flavonoids, phenolic acids, and iridoids [ 2 , 3 , 5 , 6 , 7 , 8 , 9 ]. With regard to its pharmacological properties, a wide range of biological properties, from antioxidant to antiviral, has been declared [ 2 , 3 , 5 , 10 , 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Bridging the Chemical Profiles and Biological Effects of Spathodea campanulata Extracts: A New Contribution on the Road from Natural Treasure to Pharmacy Shelves

et al. 2022

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Spathodea campanulata is an important medicinal plant with traditional uses in the tropical zone. In the current work, we aimed to determine the chemical profiles and biological effects of extracts (methanolic and infusion (water)) from the leaves and stem bark of S. campanulata. The chemical components of the tested extracts were identified using LC-ESI-QTOF-MS. Biological effects were tested in terms of antioxidant (radical scavenging, reducing power, and metal chelating), enzyme inhibitory (cholinesterase, amylase, glucosidase, and tyrosinase), antineoplastic, and antiviral activities. Fifty-seven components were identified in the tested extracts, including iridoids, flavonoids, and phenolic acids as the main constituents. In general, the leaves-MeOH extract was the most active in the antioxidant assays (DPPH, ABTS, CUPRAC, FRAP, metal chelating, and phosphomolybdenum). Antineoplastic effects were tested in normal (VERO cell line) and cancer cell lines (FaDu, HeLa, and RKO). The leaf infusion, as well as the extracts obtained from stem bark, showed antineoplastic activity (CC50 119.03–222.07 µg/mL). Antiviral effects were tested against HHV-1 and CVB3, and the leaf methanolic extract (500 µg/mL) exerted antiviral activity towards HHV-1, inhibiting the viral-induced cytopathic effect and reducing the viral infectious titre by 5.11 log and viral load by 1.45 log. In addition, molecular docking was performed to understand the interactions between selected chemical components and viral targets (HSV-1 DNA polymerase, HSV-1 protease, and HSV-1 thymidine kinase). The results presented suggest that S. campanulata may be a bright spot in moving from natural sources to industrial applications, including novel drugs, cosmeceuticals, and nutraceuticals.

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“…The work by Ngnameko et al, likewise covers the possibility offered by natural sources for the identification of bioactive molecules by reporting on the medicinal properties of Spathodea campanulata P. Beauv. (Bignoniaceae) [ 8 ]. The work shows preliminary evidence on the ability of the crude plant extract to inhibit Helicobacter pylori growth by urease inhibition and modulation of virulence factors.…”

mentioning

confidence: 99%

Novel Targets and Mechanisms in Antimicrobial Drug Discovery

Tondi

2021

Antibiotics

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New Insights into Bioactive Compounds from the Medicinal Plant Spathodea campanulata P. Beauv. and Their Activity against Helicobacter pylori

Cited by 8 publications

References 34 publications

Spathodea campanulata P. Beauv. —A review of its ethnomedicinal, phytochemical, and pharmacological profile

Spathodea campanulata P. Beauv. —A review of its ethnomedicinal, phytochemical, and pharmacological profile

Bridging the Chemical Profiles and Biological Effects of Spathodea campanulata Extracts: A New Contribution on the Road from Natural Treasure to Pharmacy Shelves

Novel Targets and Mechanisms in Antimicrobial Drug Discovery

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