New insights into epigenetics as an influencer: An associative study between maternal prenatal factors in Autism Spectrum Disorder (ASD)

Vellingiri, Balachandar; Iyer, Mahalaxmi; Raj, Neethu; Narayanasamy, Arul; Gopalakrishnan, Abilash Valsala

doi:10.1016/j.neurop.2022.01.002

Cited by 7 publications

(5 citation statements)

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“…The significant relationship between ageing and DNA methylation can be used to explain the maternal age contribution to ASD. As the mother's age rises, she is exposed to a wider range of environmental chemicals that cause DNA damage, hypermethylation, and germline mutations, which may have contributed to the development of ASD in offspring (Vellingiri et al, 2022).…”

Section: -Results Of the Arabic Preschool Language Scale (Pls4)mentioning

confidence: 99%

Environmental Aetiology of Autism and Subsequent Interventional Management

Nasser¹,

Ragab²,

Nashaat³

et al. 2022

Journal of Environmental Science

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Background: Autism spectrum disorder (ASD) is a complicated disorder. Up to 50% of its variance could be related to environmental factors. Aim: Environmental risk factors for ASD were studied among cases and controls. Additionally, the effects of some targeted interventional approaches on the severity of ASD and language abilities were compared. Methodology: This study was conducted on 61 autistic children (3-12 years) who visited the outpatient clinic for "Children with ASD" from September 2021 to February 2022. They were subjected to the Childhood Autism Rating Scale, and the Arabic Preschool Language Scale. The control subjects (N=62) were selected from volunteers. A questionnaire was designed for studying the environmental risk factors. Children with ASD were then divided into two groups: Group a (N=30) received phoniatric therapy; Group b (N=31) received phoniatric therapy and dietary supplementation. After 3 months, both groups were reassessed. Results: Risk factors such as maternal exposure to disinfectants and cleaners (78.7%), moderate maternal (39.3 %) and paternal (47.5 %) educational level, pregnancy in Summer (19.6%), delivery in Spring (19.6%) and prematurity (91.8%), showed significant statistical difference between cases and control subjects (P=0.

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Section: -Results Of the Arabic Preschool Language Scale (Pls4)mentioning

confidence: 99%

Environmental Aetiology of Autism and Subsequent Interventional Management

Nasser¹,

Ragab²,

Nashaat³

et al. 2022

Journal of Environmental Science

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“…Epigenetics include DNA methylation, histone modifications, and noncoding RNA (ncRNA) molecules such as microRNA (miRNA). [ 5 ] Specifically, aberrant DNA methylation and histone acetylation are involved in gene regulation, synaptic plasticity, neuroinflammation, and oxidative stress. [ 6 ] Furthermore, studies have shown that miRNAs are involved in gene expression which is critical for the maintenance of cognitive function.…”

Section: Introductionmentioning

confidence: 99%

“…[ 48 ] Cd induced significant death of cholinergic neurons which led to tau and Aβ production. [ 49 ] Cd‐treatment led to a deficit in memory and learning with an increase in plaque depositions and Aβ [ 1–42 ] accumulation. [ 38,47 ] Similarly, Cd treatment stimulated an aggregation of the third repeat binding fragment of tau thereby resulting in partial loss of R3 conformation leading to α‐helix structure followed by tau aggregation.…”

Section: Introductionmentioning

confidence: 99%

Heavy metals toxicity on epigenetic modifications in the pathogenesis of Alzheimer's disease (AD)

Venkatesan,

Muthukumar,

Iyer

et al. 2024

J Biochem & Molecular Tox

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Alzheimer's disease (AD) is a progressive decline in cognitive ability and behavior which eventually disrupts daily activities. AD has no cure and the progression rate varies unlikely. Among various causative factors, heavy metals are reported to be a significant hazard in AD pathogenesis. Metal‐induced neurodegeneration has been focused globally with thorough research to unravel the mechanistic insights in AD. Recently, heavy metals suggested to play an important role in epigenetic alterations which might provide evidential results on AD pathology. Epigenetic modifications are known to play towards novel therapeutic approaches in treating AD. Though many studies focus on epigenetics and heavy metal implications in AD, there is a lack of research on heavy metal influence on epigenetic toxicity in neurological disorders. The current review aims to elucidate the plausible role of cadmium (Cd), iron (Fe), arsenic (As), copper (Cu), and lithium (Li) metals on epigenetic factors and the increase in amyloid beta and tau phosphorylation in AD. Also, the review discusses the common methods of heavy metal detection to implicate in AD pathogenesis. Hence, from this review, we can extend the need for future research on identifying the mechanistic behavior of heavy metals on epigenetic toxicity and to develop diagnostic and therapeutic markers in AD.

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“…Un síndrome asociado a una etiología en común es el síndrome de X frágil (SXF). Es la causa hereditaria de un solo gen más común de discapacidad intelectual y TEA [6][7][8]. Su prevalencia es de 1 por cada 4.000-6.000 varones y de 1 por cada 8.000-12.000 mujeres [8].…”

Section: Introductionunclassified

“…Es la causa hereditaria de un solo gen más común de discapacidad intelectual y TEA [6][7][8]. Su prevalencia es de 1 por cada 4.000-6.000 varones y de 1 por cada 8.000-12.000 mujeres [8]. Este síndrome se debe a una alteración en el gen FMR1, situado en el brazo largo del cromosoma X, que provoca un bloqueo en la síntesis de la proteína FMRP, que se encarga de la activación y desactivación de otros genes que sintetizan proteínas encargadas de los procesos de sinaptogenia y dendrogenia [9][10][11].…”

Section: Introductionunclassified

Hacia un diagnóstico diferencial temprano en el trastorno del espectro autista y el síndrome de X frágil. Una revisión sistemática

Losada-Montes¹,

Peñalver-García²,

León-Estrada³

et al. 2022

RevNeurol

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Introducción. Aproximadamente el 60% de las personas con síndrome de X frágil también reciben un diagnóstico de trastorno del espectro autista. Entre estos trastornos existen tantas semejanzas como diferencias, que provocan cuadros clínicos distintos, por lo que es importante el diagnóstico diferencial temprano, de cara a conocer los déficits y fortalezas de cada niño y ajustar el tipo de intervención lo mejor posible. El presente estudio tiene como objetivo realizar una aproximación al conocimiento de la relación y las diferencias de ambas condiciones, y contribuir al diagnóstico diferencial y la posterior intervención. Materiales y métodos.Siguiendo el protocolo PRISMA-ScR, se realizaron búsquedas en las bases de datos de PsycInfo, Medline, SCOPUS y Web of Science, incluyendo los artículos científicos empíricos centrados en la etapa de los 0 a los 6 años desde 2010 a 2020. Resultados.Se seleccionaron 22 estudios en los que se trata el desarrollo inicial de estos dos trastornos y su confluencia. Los resultados se reagruparon en función de cambios morfológico-estructurales, y de las áreas cognitivas, comunicativas, socioemocionales y sensoriomotoras. Conclusiones.A nivel morfológico-estructural, parecen existir ciertos patrones de crecimiento cerebral diferenciadores entre estos trastornos. Asimismo, existen ciertas señales de alarma en las distintas áreas del desarrollo que son indicativas de comorbilidad o permiten la discriminación entre patologías, y existe cierto debate en torno a algunas de ellas, como el nivel atencional o los manierismos repetitivos.Palabras clave. Autismo. Comorbilidad. Primera infancia. Revisión sistemática. Síndrome de X frágil. Trastorno del espectro autista.

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New insights into epigenetics as an influencer: An associative study between maternal prenatal factors in Autism Spectrum Disorder (ASD)

Cited by 7 publications

References 91 publications

Environmental Aetiology of Autism and Subsequent Interventional Management

Environmental Aetiology of Autism and Subsequent Interventional Management

Heavy metals toxicity on epigenetic modifications in the pathogenesis of Alzheimer's disease (AD)

Hacia un diagnóstico diferencial temprano en el trastorno del espectro autista y el síndrome de X frágil. Una revisión sistemática

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