New insights into ferritin synthesis and function highlight a link between iron homeostasis and oxidative stress in plants

Briat, Jean‐François; Ravet, Karl; Arnaud, Nicolas; Duc, Céline; Boucherez, Jossia; Touraine, Brigitte; Cellier, Françoise; Gaymard, Frédéric

doi:10.1093/aob/mcp128

Cited by 268 publications

(210 citation statements)

References 127 publications

Supporting

Mentioning

198

Contrasting

Unclassified

Order By: Relevance

“…It has been demonstrated that ferritin plays a crucial role in iron storage in higher plants [35][36][37] and unicellular microalgae. 19,[38][39][40] On the other hand, ferritin contribution to iron storage in macroalgae or seaweeds is explored only recently, 24) although a ferritin gene is described as a stress-induced gene in a green seaweed Ulva sp.…”

Section: Unpublished Data)mentioning

confidence: 99%

The iron content and ferritin contribution in fresh, dried, and toasted nori, Pyropia yezoensis

Masuda

Yamamoto

Toyohara

2015

Bioscience, Biotechnology, and Biochemistry

View full text Add to dashboard Cite

Iron is one of the essential trace elements for humans. In this study, the iron contents in fresh, dried, and toasted nori (Pyropia yezoensis) were analyzed. The mean iron content of fresh, dried, and toasted nori were 19.0, 22.6, and 26.2 mg/100 g (dry weight), respectively. These values were superior to other food of plant origin. Furthermore, most of the iron in nori was maintained during processing, such as washing, drying, and toasting. Then, the form of iron in fresh, dried, and toasted nori was analyzed. As a result, an iron storage protein ferritin contributed to iron storage in raw and dried nori, although the precise rate of its contribution is yet to be determined, while ferritin protein cage was degraded in the toasted nori. It is the first report that verified the ferritin contribution to iron storage in such edible macroalgae with commercial importance.

show abstract

Section: Unpublished Data)mentioning

confidence: 99%

The iron content and ferritin contribution in fresh, dried, and toasted nori, Pyropia yezoensis

Masuda

Yamamoto

Toyohara

2015

Bioscience, Biotechnology, and Biochemistry

View full text Add to dashboard Cite

show abstract

“…Ferritin is the intracellular protein responsible for the sequestration, storage and release of iron. There are strong links between ferritins, protection against oxidative stress and coping with adverse conditions (Briat et al, 2009). …”

Section: Genes Showing Higher Expression Patterns In Resting Eggsmentioning

confidence: 99%

The expression pattern of dormancy-associated genes in multiple life-history stages in the rotifer Brachionus plicatilis

et al. 2010

View full text Add to dashboard Cite

Rotifer resting eggs retain their viability for several decades in a non-desiccated form and are of interest in discerning the processes associated with dormancy, since in most organisms this phenomenon is linked with desiccation. The expression pattern of candidate genes with biological functions associated with dormancy in several other organisms was examined in rotifers. High-throughput transcriptome profiling revealed three patterns of gene expression in resting eggs: (1) relatively highly expressed genes coding for LEA proteins and putative paralogs of the small heat shock protein family (shsp); (2) genes coding for ferritin (ferr), glutathione-6-transferase (gts) and HSP70, where some of the putative gene paralogs of these families show relatively high expression levels and other putative paralogs show relatively low expression levels in resting eggs; and (3) genes with relatively low expression levels in resting eggs, for trehalose-6-phosphate synthase (tps), fatty-acid binding proteins (fab) and of lipoprotein lipase (lpl) and the aquaporins gene family (aqp). Changes in the expression pattern of some members of putative gene families occurred during the obligatory dormant period of resting eggs. A transition was observed from an expression pattern of diapausing embryos to an expression pattern of amictic females, during hatching. Differences were also found in the expression pattern in the different types of females, especially in those carrying resting eggs, and in males compared with females. These results suggest putative functional significance to genes associated with dormancy in non-desiccated resting eggs. It could also be proposed that their occurrence in resting eggs is developmentally programmed to facilitate survival in case of desiccation.

show abstract

“…Besides a role as a putative Fe-storage protein, studies on plant ferritin functions have indicated a probable link between this protein and protection against oxidative stress (Briat et al 2010b). Ferritin in animals has also been documented to bind Al atoms, which might be a cellular protection mechanism, guarding against eventual accumulated oxidative damage (Sakamoto et al 2004).…”

Section: Discussionmentioning

confidence: 99%

“…Ferritin is a protein found in all the living kingdom, except in yeast, that can store up to 4,500 iron (Fe) atoms in their central cavities (Briat et al 2010b). In animal cells, ferritin is involved in the response against stresses resulting from ultraviolet irradiation, phorone (a glutathione-depleting drug), and excess iron (Vile & Tyrrell 1993, Cairo et al 1995, Déak et al 1999.…”

Section: Introductionmentioning

confidence: 99%

“…In animal cells, ferritin is involved in the response against stresses resulting from ultraviolet irradiation, phorone (a glutathione-depleting drug), and excess iron (Vile & Tyrrell 1993, Cairo et al 1995, Déak et al 1999. In plants, ferritin gene expression seems be modulated by different environmental factors, and many reports have suggested that it plays an important role in protecting cells against oxidative stress (Ravet et al 2009, Briat et al 2010b. The iron excess results to an increase in ROS, provoking oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antioxidative responses of cell suspension cultures of two Coffea arabica varieties to low aluminum levels at pH 5.8

Bottcher

Nóbile

Martins

et al. 2012

Hoehnea

View full text Add to dashboard Cite

-(Antioxidative responses of cell suspension cultures of two Coffea arabica varieties to low aluminum levels at pH 5.8). The effects of aluminum (Al) on the activities of antioxidant enzymes and ferritin expression were studied in cell suspension cultures of two varieties of Coffea arabica, Mundo Novo and Icatu, in medium with pH at 5.8. The cells were incubated with 300 μM Al 3+ , and the Al speciation as Al 3+ was 1.45% of the mole fraction. The activities of superoxide dismutase (SOD), catalase (CAT), and glutathione S-transferase (GST) were increased in Mundo Novo, whereas glutathione reductase (GR) and guaiacol peroxidase (GPOX) activities remained unchanged. SOD, GR, and GST activities were increased in Icatu, while CAT activity was not changed, and GPOX activity decreased. The expression of two ferritin genes (CaFer1 and CaFer2) were analyzed by Real-Time PCR. Al caused a downregulation of CaFER1 expression and no changes of CaFER2 expression in both varieties. The Western blot showed no alteration in ferritin protein levels in Mundo Novo and a decrease in Icatu. The differential enzymes responses indicate that the response to Al is variety-dependent.

show abstract

New insights into ferritin synthesis and function highlight a link between iron homeostasis and oxidative stress in plants

Cited by 268 publications

References 127 publications

The iron content and ferritin contribution in fresh, dried, and toasted nori, Pyropia yezoensis

The iron content and ferritin contribution in fresh, dried, and toasted nori, Pyropia yezoensis

The expression pattern of dormancy-associated genes in multiple life-history stages in the rotifer Brachionus plicatilis

Antioxidative responses of cell suspension cultures of two Coffea arabica varieties to low aluminum levels at pH 5.8

Contact Info

Product

Resources

About