New insights into germ cell migration and survival/apoptosis in spermatogenesis

Abstract

CD147, also named basigin (Bsg) or extracellular matrix (ECM) metalloproteinase inducer (EMMPRIN), is a highly glycosylated protein first identified as a tumor cell surface molecule. In cancer, it is well established that CD147 promotes metastasis by stimulating the production of MMPs. Recent studies have also suggested that it may be associated with tumor growth and angiogenesis. Interestingly, CD147 is expressed in germ cells of different development stages in the testis and its knockout mice are infertile, indicating an essential role of CD147 in spermatogenesis. While the detailed involvement of CD147 in spermatogenesis remains elusive, our recent findings have revealed a dual role of CD147 in germ cell development. On the one hand, it regulates the migration of spermatogonia and spermatocytes via the induction of MMP-2 production; on the other hand, it specifically regulates the survival/apoptosis of spermatocytes but not spermatogonia through a p53-independent pathway. In this review, we aim to provide an overview on the functions of CD147, comparing its roles in cancer and the testis, thereby providing new insights into the regulatory mechanisms underlying the process of spermatogenesis.

Nandrolone decanoate interferes with testosterone biosynthesis altering blood–testis barrier components

“…This process promotes the disassembling of basal ES and the dissolution of apical ES after secretion by Sertoli cells . Moreover, MMP‐2 was shown to disrupt Sertoli–germ cell adhesion . The immunofluorescence experiments demonstrated that ND seems to regulate MMP‐2 secretion via the induction of TIMP‐2, with consequences on spermatocytes maturation and possibly male fertility.…”

“…This process promotes the disassembling of basal ES and the dissolution of apical ES after secretion by Sertoli cells [38]. Moreover, MMP-2 was shown to disrupt Sertoli-germ cell adhesion [39].…”

CD147 Как Новая Молекула-Мишень Для Фармакотерапии В Онкологии

“… ÷àñòíîñòè, äèçðåãóëÿöèÿ àêòèâíîñòè CD147 ìîaeåò ïðèâåñòè ê ïðîãðåññèðîâàíèþ çàáîëåâàíèÿ. CD147 ðåãóëèðóåò íåñêîëüêî ðàçëè÷íûõ ôóíêöèé, âêëþ÷àÿ ñïåðìàòîãåíåç â ïîëîâûõ êëåòêàõ [9], îòâåòíóþ ðåàêöèþ ëèìôîöèòîâ ðàçëè÷íûõ ñóáïîïóëÿöèé è ýêñïðåññèþ ñèñòåìû MCT â êàðäèîìèîöèòàõ [29]. CD147 â ñîñòàâå ìåìáðàííûõ ìèêðîâåçèêóë ó÷àñòâóåò â çëîêà÷åñòâåííûõ ïðîöåññàõ â ìàòêå, â ïðîöåññàõ îòåêà ìîçãà è ïðîëèôåðàöèè òðàíñôîðìèðîâàííûõ ïëàçìàòè÷åñêèõ êëåòîê ÷åëîâåêà [8,56].…”

Epitope Mapping of Metuximab on CD147 Using Phage Display and Molecular Docking

“…It has been involved in various physiological functions such as spermatogenesis [3], embryo implantation [4], tissue remodeling [5], and diverse pathological processes such as neuroinflammation [6], Alzheimer's disease [7], malaria infection [8], and tumor progression [9]. Though widely expressed on numerous cell types, CD147 is highly enriched on the surface of cancer cells, especially on those of epithelial origin, for example, breast cancer [10] and liver cancer [11].…”