New insights into the experience of fatigue among patients with rheumatoid arthritis: a qualitative study

Nikolaus, Stephanie; Bode, Christina; Taal, Erik; Laar, Mart A F J van de

doi:10.1136/ard.2009.118067

Cited by 68 publications

(80 citation statements)

References 16 publications

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“…In FM, it appeared that there was a diurnal relationship between pain and fatigue that probably was mediated by stress or sleep quality (31,32). It may be worthwhile to evaluate sex differences; for example, it has been found that especially younger women with multiple daily roles seemed to be vulnerable to the negative impact of RA fatigue (33). However, in our study, no difference between men and women was found.…”

Section: Discussioncontrasting

confidence: 54%

Association Between Fatigue and Pain in Rheumatoid Arthritis: Does Pain Precede Fatigue or Does Fatigue Precede Pain?

Dartel

Repping-Wuts

Hoogmoed

et al. 2013

Arthritis Care & Research

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Objective. Fatigue and pain are important symptoms for patients with rheumatoid arthritis (RA), but their temporal association is unknown. Therefore, the objective of this study was to investigate the longitudinal relationship between fatigue and pain in patients with RA using time-lag models. Methods. Consecutive RA outpatients (n ‫؍‬ 228) were enrolled for this 1-year study. Fatigue was assessed monthly with the Checklist Individual Strength (CIS; range 8 -56) and pain was assessed monthly with the bodily pain subscale (inverted, range 0 -100) of the Short Form 36. The association between monthly changes in fatigue and pain was analyzed using longitudinal regression (mixed models), using the same months and with a 1-month time lag. Results. A total of 198 patients were included in the analyses. At baseline, the mean ؎ SD pain score was 35.23 ؎ 19.82 and the mean ؎ SD CIS fatigue score was 31.0 ؎ 12.4. Severe fatigue at baseline (CIS score >35) was present in 42% of the patients. The mean ؎ SD patient-averaged CIS fatigue score over 1 year was 30.9 ؎ 6.0 and the mean ؎ SD patient-averaged pain score over 1 year was 36.4 ؎ 18.3. The longitudinal regression analysis showed a significant positive relationship between fatigue and pain during the same month (␤ ‫؍‬ 2.04; 95% confidence interval 1.82, 2.27). The models using a time lag showed no significant association between changes in pain and changes in fatigue. Conclusion. In established RA, pain and fatigue show monthly fluctuations that are synchronous rather than showing a temporal relationship with a time lag; within this timeframe, the results do not indicate that one precedes the other.

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Section: Discussioncontrasting

confidence: 54%

Association Between Fatigue and Pain in Rheumatoid Arthritis: Does Pain Precede Fatigue or Does Fatigue Precede Pain?

Dartel

Repping-Wuts

Hoogmoed

et al. 2013

Arthritis Care & Research

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“…It was reported that experience of fatigue varies with respect to age, sex, emotions, and daily roles. Nikolous et al 40 showed that effects and experiences of fatigue vary individually. Particularly, young females with multiple daily roles have greater tendency to experience negative effects of fatigue.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Sexual Dysfunction in Females With Ankylosing Spondylitis

Akkurt

Yılmaz

et al. 2016

Arch Rheumatol

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Objectives: This study aims to evaluate sexual function in females with ankylosing spondylitis (AS), compare them with healthy controls, and demonstrate the effects of AS on female sexual functions. Patients and methods: Fifty-four AS patients (mean age 39.33±8.57 years; range 20 to 55 years) and 56 similar aged healthy controls were included in the study. Depression levels and sexual functions of all participants were evaluated by the Beck Depression Inventory and Female Sexual Function Index (FSFI), respectively. Other assessment methods included the visual analog scale for pain, fatigue, and importance of sexual life; Bath Ankylosing Spondylitis Disease Activity Index for disease activity, Bath Ankylosing Spondylitis Functional Index for functionality, Bath Ankylosing Spondylitis Metrology Index for spinal mobility, and Short Form-36 (SF-36) for quality of life. Results: Total FSFI and all FSFI subscale scores and number of weekly sexual intercourse were significantly lower while Beck Depression Inventory score was significantly higher in females with AS when compared to controls. In AS patients with depression, total FSFI score and FSFI subscales scores of desire and arousal were significantly lower than those without depression. In females with AS, there were negative correlations between total FSFI score and duration of complaint, Beck Depression Inventory score, Bath Ankylosing Spondylitis Metrology Index score, visual analog scale score, age, and duration of marriage while positive correlations existed between total FSFI score and visual analog scale importance of sexual life score and number of weekly sexual intercourse, SF-36 fatigue, SF-36 social function, SF-36 pain, and SF-36 mental component scores. Conclusion: Sexual dysfunction was more common in female AS patients without marked impairment in body image and hip involvement when compared to normal population. Sexual problems which are generally neglected should be handled regardless of disease activity when evaluating patients with AS and establishing a treatment plan.

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“…However, this domain is considered an important issue in other rheumatic diseases; several qualitative studies (107,108) have pointed out the importance of fatigue for patients with RA. In RA, fatigue is considered intrusive and overwhelming and has consequences on all aspects of quality of life (107,108). In PsA, however, there is a lack of data regarding the importance of fatigue for patients.…”

Section: Discussionmentioning

confidence: 99%

Clinical outcomes in psoriatic arthritis: A systematic literature review

Palominos¹,

Gaujoux-Viala²,

Fautrel³

et al. 2012

Arthritis Care & Research

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Objective. Many outcomes have been proposed in the assessment of psoriatic arthritis (PsA). The Outcome Measures in Rheumatology (OMERACT) core set for PsA evaluation comprises 6 domains: joints, skin, function, pain, patient's global assessment, and quality of life. The objective of this work was to assess reporting of outcomes in PsA, including patient-reported outcomes (PROs) in recent publications. Methods. A systematic literature search of clinical trials related to PsA and reporting at least 1 clinical outcome between 2006 and 2010 was performed in PubMed, i.e., just before to just after publication of the OMERACT core set. All clinical outcomes were noted and subdivided into domains of health. Data analysis was descriptive. Results. Fifty-eight articles (12,405 patients) were included in the analysis: 17 (29%) were randomized clinical trials; the patients' mean ؎ SD age was 48.2 ؎ 5.4 years and the mean ؎ SD disease duration was 9.0 ؎ 3.1 years. Eighty-four different outcomes were reported, with a mean ؎ SD of 6.9 ؎ 4.3 per study. Patients were mainly assessed using the 6 core set domains, reported in 37.9% (quality of life) to 55.2% (skin) of articles; however, the core set was rarely completely reported since only 10.3% of the studies reported all 6 core domains. PROs were heterogeneous and in particular there was no consensus regarding the number of joints to assess and instruments for dactylitis and enthesitis. PROs were assessed in more than 75% of publications using 28 different instruments. Conclusion. There is great heterogeneity in PsA assessment, even since publication of the OMERACT core set. Better consensus on instruments to assess each domain of health and better insight into which outcomes are important for patients is needed.

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New insights into the experience of fatigue among patients with rheumatoid arthritis: a qualitative study

Cited by 68 publications

References 16 publications

Association Between Fatigue and Pain in Rheumatoid Arthritis: Does Pain Precede Fatigue or Does Fatigue Precede Pain?

Association Between Fatigue and Pain in Rheumatoid Arthritis: Does Pain Precede Fatigue or Does Fatigue Precede Pain?

Evaluation of Sexual Dysfunction in Females With Ankylosing Spondylitis

Clinical outcomes in psoriatic arthritis: A systematic literature review

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