New Insights into the Pathogenesis of Idiopathic Cardiac Fibrosis in European Captive Chimps

Baiker, Kerstin; Strong, Victoria; Moittié, Sophie; Redrobe, Sharon; MacDonald, C; Liptovszky, Mátyás; Cobb, Malcolm; White, Kate

doi:10.1016/j.jcpa.2017.10.051

Cited by 2 publications

(3 citation statements)

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“…After myocardial system injury, fibroblasts are transformed into myofibroblasts due to the interaction among various acute inflammatory cell transforming growth factors and cytokines, thereby promoting MF. Presently, vimentin is widely used as the extracellular matrix of myofibroblasts, whereas α-smooth muscle actin is used as a specific marker ( Baiker et al, 2018 ) to promote the activation of myofibroblasts. The trans-differentiation of myofibroblasts requires several key factors.…”

Section: Myocardial Fibrosis Mechanism According To Modern Medicinementioning

confidence: 99%

Research Progress of Traditional Chinese Medicine in Treatment of Myocardial fibrosis

Ren

Zhao

et al. 2022

Front. Pharmacol.

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Effective drugs for the treatment of myocardial fibrosis (MF) are lacking. Traditional Chinese medicine (TCM) has garnered increasing attention in recent years for the prevention and treatment of myocardial fibrosis. This Article describes the pathogenesis of myocardial fibrosis from the modern medicine, along with the research progress. Reports suggest that Chinese medicine may play a role in ameliorating myocardial fibrosis through different regulatory mechanisms such as reduction of inflammatory reaction and oxidative stress, inhibition of cardiac fibroblast activation, reduction in extracellular matrix, renin-angiotensin-aldosterone system regulation, transforming growth Factor-β1 (TGF-β1) expression downregulation, TGF-β1/Smad signalling pathway regulation, and microRNA expression regulation. Therefore, traditional Chinese medicine serves as a valuable source of candidate drugs for exploration of the mechanism of occurrence and development, along with clinical prevention and treatment of MF.

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Section: Myocardial Fibrosis Mechanism According To Modern Medicinementioning

confidence: 99%

Research Progress of Traditional Chinese Medicine in Treatment of Myocardial fibrosis

Ren

Zhao

et al. 2022

Front. Pharmacol.

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“…Cardiovascular disease has been identified as a significant cause of mortality in captive great apes of all taxa, with a large proportion of these presenting as sudden death 3 . Histopathological evaluation in chimpanzees in particular has described interstitial and replacement fibrosis within the myocardium 4 . The aetiopathogenesis of this is unclear, but the development of arrhythmias is suspected 5 .…”

Section: Introductionmentioning

confidence: 99%

“…3 Histopathological evaluation in chimpanzees in particular has described interstitial and replacement fibrosis within the myocardium. 4 The aetiopathogenesis of this is unclear, but the development of arrhythmias is suspected. 5 However, given the smaller captive and free-living populations of bonobos, less is known about this species in comparison to their close relatives chimpanzees.…”

Section: Introductionmentioning

confidence: 99%

Cardiorespiratory effects of isoflurane and medetomidine–tiletamine–zolazepam in 12 bonobos (Pan paniscus)

Bucknell¹,

Dobbs²,

Martin³

et al. 2023

Veterinary Record

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Background Cardiovascular disease is a significant cause of mortality in captive great apes. However, data from bonobos are lacking due to a paucity of collections in Europe. Comprehensive preventive screening is required to understand the aetiopathogenesis of cardiovascular disease, but the provision of a stable and predictable anaesthetic protocol with minimal cardiovascular effects is challenging. Methods This prospective, observational case series reports anaesthesia of 12 bonobos using hand‐injected medetomidine and tiletamine–zolazepam followed by maintenance with isoflurane in oxygen. Comprehensive clinical examinations, including arterial blood gases and echocardiography were undertaken. Results Induction of anaesthesia with hand injection was successful in all but one individual. Respiratory acidosis with metabolic alkalosis and respiratory alkalosis with metabolic acidosis were documented. Hypochloraemia may have contributed to non‐respiratory alkalosis in one individual. Ten bonobos experienced hypotension and required haemodynamic support. Both N‐terminal pro b‐type natriuretic peptide and troponin I cardiac biomarkers correlated with left ventricular ejection fraction (percentage). Recovery was smooth, rapid and uneventful in all animals. Limitations The effects of the anaesthetic must be considered during echocardiographical interpretation. Conclusions The anaesthesia protocol provided a safe, predictable induction and recovery, facilitating diagnostics (including echocardiography) and minor surgical procedures. Comprehensive monitoring, including invasive blood pressure monitoring and haemodynamic support, is highly recommended.

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New Insights into the Pathogenesis of Idiopathic Cardiac Fibrosis in European Captive Chimps

Cited by 2 publications

References 0 publications

Research Progress of Traditional Chinese Medicine in Treatment of Myocardial fibrosis

Research Progress of Traditional Chinese Medicine in Treatment of Myocardial fibrosis

Cardiorespiratory effects of isoflurane and medetomidine–tiletamine–zolazepam in 12 bonobos (Pan paniscus)

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