New insights into the relationship between suture closure and craniofacial dysmorphology in sagittal nonsyndromic craniosynostosis

Heuzé, Yann; Boyadjiev, Simeon A.; Marsh, Jeffrey L.; Kane, Alex A.; Cherkez, Elijah; Boggan, James E.; Richtsmeier, Joan T.

doi:10.1111/j.1469-7580.2010.01258.x

Cited by 58 publications

(59 citation statements)

References 32 publications

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“…1a). However, there is a great variability in the scaphocephalic morphology of sagittal synostosis that involves not only the cranial vault but also the facial skeleton and cranial base [9]. Little is known about the sources of this heterogeneity.…”

Section: Introductionmentioning

confidence: 99%

Closing the Gap: Genetic and Genomic Continuum from Syndromic to Nonsyndromic Craniosynostoses

et al. 2014

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Craniosynostosis, a condition that includes the premature fusion of one or multiple cranial sutures, is a relatively common birth defect in humans and the second most common craniofacial anomaly after orofacial clefts. There is a significant clinical variation among different sutural synostoses as well as significant variation within any given single-suture synostosis. Craniosynostosis can be isolated (i.e., nonsyndromic) or occurs as part of a genetic syndrome (e.g., Crouzon, Pfeiffer, Apert, Muenke, and Saethre-Chotzen syndromes). Approximately 85 % of all cases of craniosynostosis are nonsyndromic. Several recent genomic discoveries are elucidating the genetic basis for nonsyndromic cases and implicate the newly identified genes in signaling pathways previously found in syndromic craniosynostosis. Published epidemiologic and phenotypic studies clearly demonstrate that nonsyndromic craniosynostosis is a complex and heterogeneous condition supporting a strong genetic component accompanied by environmental factors that contribute to the pathogenetic network of this birth defect. Large population, rather than single-clinic or hospital-based studies is required with phenotypically homogeneous subsets of patients to further understand the complex genetic, maternal, environmental, and stochastic factors contributing to nonsyndromic craniosynostosis. Learning about these variables is a key in formulating the basis of multidisciplinary and lifelong care for patients with these conditions.

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Section: Introductionmentioning

confidence: 99%

Closing the Gap: Genetic and Genomic Continuum from Syndromic to Nonsyndromic Craniosynostoses

et al. 2014

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“…13,14 It results from the premature fusion of the sagittal suture and affects approximately 1:2000 live births. 9 Males are more affected by a ratio of 10:7. 3,11,26 Scaphocephaly causes an anteroposterior elongation of the skull, bifrontal bossing, bilateral parietal narrowing, flattening of the vertex region, and excessive occipital convexity.…”

mentioning

confidence: 99%

“…), or due to defective brain growth. 2,[8][9][10][11][12] Scaphocephaly is the most common nonsyndromic unisutural craniosynostosis (55%-60%). 13,14 It results from the premature fusion of the sagittal suture and affects approximately 1:2000 live births.…”

mentioning

confidence: 99%

Occlusal Relations in Patients With Scaphocephaly

Lebuis

Bortoluzzi²,

Huynh³

et al. 2015

Journal of Craniofacial Surgery

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Scaphocephaly results from a premature fusion of the sagittal suture. Usually, cranial vault corrective surgery is performed during the first year of life. There is currently no scientific data regarding occlusion of scaphocephalic patients, or the potential effect of craniovault surgery on the occlusion. The aims were to describe occlusion in scaphocephalic patients and compare with a general pediatric population, and to compare the difference in occlusion of surgically versus unoperated treated scaphocephalic subgroup. A total of 91 scaphocephalic patients (71 boys aged between 2 and 11 y) seen at the Craniofacial Clinic of CHU Ste-Justine's formed the experimental group. All patients received an orthodontic assessment. Among them, 44 underwent craniovault surgery, whereas 47 remained unoperated. Thirty-eight (33 boys; 17 operated) had lateral cephalometric radiographies, some of them also had cephalometric growth follow-ups. Clinical values for dental classification and overjet indicate an increased prevalence of class II malocclusions in scaphocephalic patients. However, interestingly enough, cephalometric values indicative of skeletal class II malocclusions (ie, N-A perp HP, N-B perp HP, N-Pog perp HP, Wits, N-A-Pog) remained within normal limits. Some cephalometric values present statistically significant differences between operated and unoperated patients (ANS-PNS t2, P = 0.025; /1-FH t2, P = 0.028), but these are individual variations not related to scaphocephaly. Maxillary width of scaphocephalic children remains within normal limits. Scaphocephalic patients clinically presented more class II malocclusions compared with normal children. Radiographic values remain, however, within normal limits for both anteroposterior and transverse dimensions. Corrective craniovault surgery did not affect occlusion in these patients.

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“…The level of suture closure between these two subjects is very similar and can easily be misunderstood. Of course this is a preliminary study and it is necessary to collect additional data to strengthen these recommendations [8][9][10][11][12][13].…”

Section: Resultsmentioning

confidence: 99%

“…This method experiences problems with both accuracy and precision of the determined age at death. By observing ectocranial sutures during autopsy activities, the authors focus their attention on the morphology of the sutures and their level of obliteration [1][2][3][4][5][6][7][8]. From a sample of 100 individuals, the inaccuracy and imprecision of the Meindl and Lovejoy method was evident.…”

Section: Introductionmentioning

confidence: 99%

A Preliminary Study of the Relationship between Obliteration of Cranial Sutures and Age at Time of Death

Donato¹,

Cipolloni²,

Ozonoff³

et al. 2016

Biol syst Open Access

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During a forensic investigation, the determination of age at death is typically based on the level of skeletal development. Cranial sutures may help a forensic investigator to determine age at death since there is a predictable interval of age linked to their obliteration. The progression of the obliteration is divided in four stages (from 0 to 3), with the last stage indicating complete obliteration, and specific locations on the sutures are considered most useful for the estimation of age at death. However as more of the sutures are obliterated, the traditionally reported interval of age at death grows wider, with a complete obliteration of the sutures referred to a range of 34 to 76 years. Thus one would expect that the cranial sutures of an older person should be completely obliterated. When completely closed, which should happen over the age of 80 years, the sutures nearly disappear and at the last level of obliteration they are no longer visible, in this preliminary study, the authors analyzed a sample of 100 skull photographs taken during post mortem examinations. This study is focused on a macroscopic study of sagittal and coronal sutures. In some cases, the complete obliteration of cranial sutures was visible for individuals with age ranging from 60 to 70 years old. In particular the authors observed the presence of sutures that were not completely obliterated in subjects aged more than 70 years. The aims of this study were to draw attention to these features; to avoid misinterpretation about the age of skeletal remains; and to offer evidence that these criteria may not be reliable for forensic investigation, at least until further study and recalibration to known data.

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New insights into the relationship between suture closure and craniofacial dysmorphology in sagittal nonsyndromic craniosynostosis

Cited by 58 publications

References 32 publications

Closing the Gap: Genetic and Genomic Continuum from Syndromic to Nonsyndromic Craniosynostoses

Closing the Gap: Genetic and Genomic Continuum from Syndromic to Nonsyndromic Craniosynostoses

Occlusal Relations in Patients With Scaphocephaly

A Preliminary Study of the Relationship between Obliteration of Cranial Sutures and Age at Time of Death

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