2024
DOI: 10.1002/cam4.7390
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New insights into the role of tetraspanin 6, 7, and 8 in physiology and pathology

Monika Mrozowska,
Tomasz Górnicki,
Mateusz Olbromski
et al.

Abstract: BackgroundThe tetraspanin (TSPAN) family comprises 33 membrane receptors involved in various physiological processes in humans. Tetrasapanins are surface proteins expressed in cells of various organisms. They are localised to the cell membrane by four transmembrane domains (TM4SF). These domains bind several cell surface receptors and signalling proteins to tetraspanin‐enriched lipid microdomains (TERM or TEM). Tetraspanins play a critical role in anchoring many proteins. They also act as a scaffold for cell s… Show more

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