New insights into transcriptome variation during cattle adipocyte adipogenesis by direct RNA sequencing

Peng, Lingwei; Zhang, Xiaolian; Du, Yuqin; Li, Fan; Han, Jiazheng; Liu, Oujin; Dai, Shoulu; Zhang, Xiang; Liu, George E.; Yang, Liguo; Zhou, Yang

doi:10.1016/j.isci.2023.107753

Cited by 3 publications

(1 citation statement)

References 58 publications

(68 reference statements)

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“…Researchers sequenced RNA from different periods of bovine fat cells using ONT sequencing. The direct sequencing of full-length RNA accurately reflected the RNA modification status, detecting modifications at the single-base level and their potential roles in gene expression and selective splicing in fat cells, enhancing our understanding of the mechanisms underlying fat formation in cattle [75]. Additionally, studies on different mRNA modifications implied that TGS technology plays a crucial role in the discovery of new transcripts in animals (Table 2).…”

Section: Application Of Tgs In the Transcriptome Of Ruminant Animalsmentioning

confidence: 99%

When Livestock Genomes Meet Third-Generation Sequencing Technology: From Opportunities to Applications

Liu,

Zheng,

Ding

et al. 2024

Genes

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Section: Application Of Tgs In the Transcriptome Of Ruminant Animalsmentioning

confidence: 99%

When Livestock Genomes Meet Third-Generation Sequencing Technology: From Opportunities to Applications

Liu,

Zheng,

Ding

et al. 2024

Genes

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Alternative splicing and related RNA binding proteins in human health and disease

Tao,

Zhang,

Wang

et al. 2024

Sig Transduct Target Ther

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Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation, engendering transcript diversity, and modifications in protein structure and functionality. Across varying tissues, developmental stages, or under specific conditions, AS gives rise to distinct splice isoforms. This implies that these isoforms possess unique temporal and spatial roles, thereby associating AS with standard biological activities and diseases. Among these, AS-related RNA-binding proteins (RBPs) play an instrumental role in regulating alternative splicing events. Under physiological conditions, the diversity of proteins mediated by AS influences the structure, function, interaction, and localization of proteins, thereby participating in the differentiation and development of an array of tissues and organs. Under pathological conditions, alterations in AS are linked with various diseases, particularly cancer. These changes can lead to modifications in gene splicing patterns, culminating in changes or loss of protein functionality. For instance, in cancer, abnormalities in AS and RBPs may result in aberrant expression of cancer-associated genes, thereby promoting the onset and progression of tumors. AS and RBPs are also associated with numerous neurodegenerative diseases and autoimmune diseases. Consequently, the study of AS across different tissues holds significant value. This review provides a detailed account of the recent advancements in the study of alternative splicing and AS-related RNA-binding proteins in tissue development and diseases, which aids in deepening the understanding of gene expression complexity and offers new insights and methodologies for precision medicine.

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Long non-coding RNA (LncRNA) and epigenetic factors: their role in regulating the adipocytes in bovine

Jilo,

Abebe,

Wang

et al. 2024

Front. Genet.

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Investigating the involvement of long non-coding RNAs (lncRNAs) and epigenetic processes in bovine adipocytes can provide valuable new insights into controlling adipogenesis in livestock. Long non-coding RNAs have been associated with forming chromatin loops that facilitate enhancer-promoter interactions during adipogenesis, as well as regulating important adipogenic transcription factors like C/EBPα and PPARγ. They significantly influence gene expression regulation at the post-transcriptional level and are extensively researched for their diverse roles in cellular functions. Epigenetic modifications such as chromatin reorganization, histone alterations, and DNA methylation subsequently affect the activation of genes related to adipogenesis and the progression of adipocyte differentiation. By investigating how fat deposition is epigenetically regulated in beef cattle, scientists aim to unravel molecular mechanisms, identify key regulatory genes and pathways, and develop targeted strategies for modifying fat deposition to enhance desirable traits such as marbling and meat tenderness. This review paper delves into lncRNAs and epigenetic factors and their role in regulating bovine adipocytes while focusing on their potential as targets for genetic improvement to increase production efficiency. Recent genomics advancements, including molecular markers and genetic variations, can boost animal productivity, meeting global demands for high-quality meat products. This review establishes a foundation for future research on understanding regulatory networks linked to lncRNAs and epigenetic changes, contributing to both scholarly knowledge advancement and practical applications within animal agriculture.

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New insights into transcriptome variation during cattle adipocyte adipogenesis by direct RNA sequencing

Cited by 3 publications

References 58 publications

When Livestock Genomes Meet Third-Generation Sequencing Technology: From Opportunities to Applications

When Livestock Genomes Meet Third-Generation Sequencing Technology: From Opportunities to Applications

Alternative splicing and related RNA binding proteins in human health and disease

Long non-coding RNA (LncRNA) and epigenetic factors: their role in regulating the adipocytes in bovine

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