New insights on IgA vasculitis with underlying solid tumor: a nationwide French study of 30 patients

Hankard, Antoine; Michot, Jean‐Marie; Terrier, Benjamin; Brihaye, B.; Chanal, J.; Combe, Christian; Karras, Alexandre; Urbanski, G.; Amoura, Zahir; Darrigade, Anne‐Sophie; Deroux, Alban; Guerville, Florent; Burel, Le Sébastien; Maigné, G.; Mékinian, A.; Moulis, Guillaume; Rivière, Étienne; Vandamme-Giard, Carole; Maillot, F.; Boysson, Hubert de; Aouba, Achille; Audemard-Verger, Alexandra

doi:10.1007/s10067-020-05455-z

Cited by 11 publications

(8 citation statements)

References 23 publications

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Section: Discussionmentioning

confidence: 99%

“…In one clinical practice, 19 patients who were diagnosed with IgAV with cancer received systemic treatment for vasculitis, including oral glucocorticoids (n=18), cyclophosphamide (n=1), and colchicine (n=2). 12 The exact cause of IgAV in adults remains unknown, although malignancy has been reported as a causative factor. Mitsui et al 13 report that 23 (43.4%) patients among 53 IgAV patients aged 41 years or older had a malignant tumor as an underlying disease.…”

mentioning

confidence: 99%

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IgA Vasculitis in a Lung Cancer Patient During Chemoradiotherapy

Taoka¹,

Ochi²,

Mimura³

et al. 2021

TCRM

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A 72-year-old man with locally advanced lung squamous cell carcinoma experienced red purpura on the lower legs and hematuria when the disease progressed during definitive chemoradiotherapy. He had renal dysfunction and proteinuria. Biopsy specimens of the skin lesion and kidney revealed immunoglobulin A vasculitis. Potential causes such as paraneoplastic syndrome and cancer treatment have been proposed. The administration of steroids rapidly improved the symptoms. The presentation of immunoglobulin A vasculitis is accompanied by malignancies. Clinicians should keep this syndrome in mind, even during curative-intent treatment.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

IgA Vasculitis in a Lung Cancer Patient During Chemoradiotherapy

Taoka¹,

Ochi²,

Mimura³

et al. 2021

TCRM

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“…Incidence rates have ranged from 2.5% (N = 81; N = 85) 2,15 to 10% (N = 260). 44,47 Most cancers associated with IgAV are solid organ, primarily mucosal, which argues for a related pathogenesis given the IgA mucosal connection. 47 In addition, when cancers are diagnosed in patients with IgAV, they are typically found in the 6 months preceding or following IgAV diagnosis.…”

Section: Jaad Intmentioning

confidence: 99%

“…44,47 Most cancers associated with IgAV are solid organ, primarily mucosal, which argues for a related pathogenesis given the IgA mucosal connection. 47 In addition, when cancers are diagnosed in patients with IgAV, they are typically found in the 6 months preceding or following IgAV diagnosis. 47 Interestingly, 1 consistent finding is the identification of higher serum IgA levels in patients with IgAV with malignancy.…”

Section: Jaad Intmentioning

confidence: 99%

“…47 In addition, when cancers are diagnosed in patients with IgAV, they are typically found in the 6 months preceding or following IgAV diagnosis. 47 Interestingly, 1 consistent finding is the identification of higher serum IgA levels in patients with IgAV with malignancy. 13,47 Hankard et al 47 found that adults with malignancy-associated IgAV had median serum IgA levels of approximately 4.5 mg/dL compared with 3.6 mg/dL in patients without associated cancer (P \ .0083, N = 30).…”

Section: Jaad Intmentioning

confidence: 99%

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