New Insights on Non-B non-C Hepatocellular Carcinoma in Mid Delta Region, Egypt

Azm, Abdel Raouf Abou El; Yousef, Mohamed; Mansour, Nagwa; Awad, Aymen; Dardiry, Samia El; Aziz, Ibrahim Abdel

doi:10.1007/s12029-013-9573-8

Cited by 9 publications

(7 citation statements)

References 35 publications

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“…This sector is at high risk for pesticides exposure and consequently high risk for developing HCC especially among rural males in addition to exposure to other risk factors (HBV and HCV) [4,6,29,30]. In mid delta region in Egypt, both pesticides and fertilizers have been suggested to be an independent risk factor for HCC [31].…”

Section: (A) Chemical Compoundsmentioning

confidence: 99%

“…Recently, a systematic review of 81 epidemiological studies [35] showed that there is an increase in the incidence of HCC risk and mortality among cigarette smokers. In Egypt, conflicting results were found regarding the association between tobacco smoking and the overall risk of HCC [5,30,31]. There is gender variation of HCC incidence being the fifth most common cancer in men (7.5%) and the ninth in women (3.4%) [10].…”

Section: (C) Smokingmentioning

confidence: 99%

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Hepatocellular Carcinoma (HCC) in Egypt: A comprehensive overview

Rashed

Kandeil

Mahmoud

et al. 2020

J Egypt Natl Canc Inst

208

163

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Background: Worldwide, hepatocellular carcinoma (HCC) is a universal problem and its epidemiological data showed variation from place to place. Hepatocellular carcinoma (HCC) is the sixth and fourth common cancer in worldwide and Egypt, respectively. Egypt ranks the third and 15 th most populous country in Africa and worldwide, respectively. The aim of this review is to compare the status of HCC in Egypt to that in the worldwide from different issues; risk factors, screening and surveillance, diagnosis and treatment, prevention, as well as research strategy. Main body: The risk factors for HCC in Egypt are of great importance to be reported. The risk factor for HCC are either environmental-or host/genetic-related risk factors. In the last years, there is a tangible improvement of both screening and surveillance strategies of HCC in Egypt. The unprecedented national screening campaign launched by the end of 2018 is a mirror image of this improvement. While the improvement of the HCC prevention requires the governmental health administration to implement health policies. Although the diagnosis of Egyptian HCC patients follows the international guidelines but HCC treatment options are limited in terms of cost. In addition, there are limited Egyptian reports about HCC survival and relapse. Both basic and clinical HCC research in Egypt are still limited compared to worldwide. Short conclusion: Deep analysis and understanding of factors affecting HCC burden variation worldwide help in customization of efforts exerted to face HCC in different countries especially large country like Egypt. Overall, the presence of a research strategy to fight HCC in Egyptian patients will help in the optimum allocation of available resources to reduce the numbers of HCC cases and deaths and to improve the quality of life.

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Section: (A) Chemical Compoundsmentioning

confidence: 99%

Section: (C) Smokingmentioning

confidence: 99%

Hepatocellular Carcinoma (HCC) in Egypt: A comprehensive overview

Rashed

Kandeil

Mahmoud

et al. 2020

J Egypt Natl Canc Inst

208

163

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“…To supply the demand many countries, including Brazil, have adopted intensive agricultural practices, with heavy use of chemical fertilizers and an array of chemical treatments to combat pests (insecticides, pesticides, fungicides) and competing plants (herbicides), all of which have a negative impact on the environment [2–4]. Although coffee consumption has been linked to numerous physiological benefits [5–8], several studies have associated pesticides or herbicides in coffee agriculture to health problems [9, 10], including various types of cancer [11]. More recently, organic farming, which removes the use of chemical treatments [12], has provided a healthier alternative that benefits consumers, farmers, and the environment.…”

Section: Introductionmentioning

confidence: 99%

Prokaryotic Diversity in the Rhizosphere of Organic, Intensive, and Transitional Coffee Farms in Brazil

Caldwell

Silva

et al. 2015

PLoS ONE

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Despite a continuous rise in consumption of coffee over the past 60 years and recent studies showing positive benefits linked to human health, intensive coffee farming practices have been associated with environmental damage, risks to human health, and reductions in biodiversity. In contrast, organic farming has become an increasingly popular alternative, with both environmental and health benefits. This study aimed to characterize and determine the differences in the prokaryotic soil microbiology of three Brazilian coffee farms: one practicing intensive farming, one practicing organic farming, and one undergoing a transition from intensive to organic practices. Soil samples were collected from 20 coffee plant rhizospheres (soil directly influenced by the plant root exudates) and 10 control sites (soil 5 m away from the coffee plantation) at each of the three farms for a total of 90 samples. Profiling of 16S rRNA gene V4 regions revealed high levels of prokaryotic diversity in all three farms, with thousands of species level operational taxonomic units identified in each farm. Additionally, a statistically significant difference was found between each farm’s coffee rhizosphere microbiome, as well as between coffee rhizosphere soils and control soils. Two groups of prokaryotes associated with the nitrogen cycle, the archaeal genus Candidatus Nitrososphaera and the bacterial order Rhizobiales were found to be abundant and statistically different in composition between the three farms and in inverse relationship to each other. Many of the nitrogen-fixing genera known to enhance plant growth were found in low numbers (e.g. Rhizobium, Agrobacter, Acetobacter, Rhodospirillum, Azospirillum), but the families in which they belong had some of the highest relative abundance in the dataset, suggesting many new groups may exist in these samples that can be further studied as potential plant growth-promoting bacteria to improve coffee production while diminishing negative environmental impacts.

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“…In some countries such as Egypt, exposure to inorganic compounds like pesticides and fertilizers has been suggested to be an independent risk factor for HCC 37 . Similarly, dietary aflatoxin is a known risk factor for HCC 38…”

Section: Hcc Risk Factors Screening and Early Diagnosis In Mena Regio...mentioning

confidence: 99%

“…36 In some countries such as Egypt, exposure to inorganic compounds like pesticides and fertilizers has been suggested to be an independent risk factor for HCC. 37 Similarly, dietary aflatoxin is a known risk factor for HCC. 38 The responses obtained from the experts indicate an increasing trend in the incidence of HCC in the MENA region.…”

Section: Risk Factors Associated With Hcc In the Mena Regionmentioning

confidence: 99%

Multidisciplinary consensus recommendations for management of hepatocellular carcinoma in Middle East and North Africa region

Waked,

Alsammany,

Tirmazy

et al. 2023

Liver International

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Hepatocellular carcinoma (HCC) is a growing health concern projected to cross over a million cases worldwide by 2025. HCC presents a significant burden of disease in Middle East and North African (MENA) countries due to a high prevalence of risk factors such as hepatitis C and B infections and rising incidence of non‐alcoholic steatohepatitis and non‐alcoholic fatty liver disease. In August 2022, an advisory meeting consisting of experts from 5 MENA countries was convened in an attempt to provide consensus recommendations on HCC screening, early diagnosis, current treatment modalities and unmet medical needs in the region. Data were collected from a pre‐meeting survey questionnaire and responses analysed and presented during the advisory meeting. This review summarizes the evidence discussed at the meeting and provides expert recommendations on the management of HCC. The 2022 update of Barcelona clinic liver cancer (BCLC) staging and treatment strategy and its implementation in the MENA region was extensively discussed. A key consensus of the expert panel was that multidisciplinary care is crucial to effective patient management that results in better clinical outcomes and overall survival of the patient. The panel recommended the use of predictive and early response biomarkers to guide clinicians in arriving at more effective therapeutic decisions. The experts also emphasized the role of robust screening/surveillance systems, population‐based registries, effective referral pathways and standardization of guidelines to ensure the successful management of HCC in the region.

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New Insights on Non-B non-C Hepatocellular Carcinoma in Mid Delta Region, Egypt

Abstract: Pesticides and smoking heavy exposure can be considered as primary risks for non-B non-C HCC. Phosphate and ammonium sulfate fertilizers were associations. The study will increase awareness for better prevention and management.

Cited by 9 publications

References 35 publications

Hepatocellular Carcinoma (HCC) in Egypt: A comprehensive overview

Hepatocellular Carcinoma (HCC) in Egypt: A comprehensive overview

Prokaryotic Diversity in the Rhizosphere of Organic, Intensive, and Transitional Coffee Farms in Brazil

Multidisciplinary consensus recommendations for management of hepatocellular carcinoma in Middle East and North Africa region

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