New kappa opioid receptor from zebrafish Danio rerio

Morphine Regulates Dopaminergic Neuron Differentiation via miR-133b

“…The study of the direct effects of morphine in the embryos will provide a better understanding on the molecular mechanisms that underlie the physical and neurobehavioral defects shown in fetuses and offspring after maternal morphine consumption (Nasiraei-Moghadam et al, 2010). In addition, the endogenous opioid system has been characterized in the zebrafish, which has a MOR (zfMOR), two DOR duplicates (zfDOR1 and zfDOR2), a -opioid receptor, and an opioid receptor-like Rodriguez et al, 2000;Alvarez et al, 2006;Pinal-Seoane et al, 2006). The opioid-induced drug addiction pathway has been suggested to involve the midbrain dopaminergic neurons lo-cated within ventral tegmental area and the nucleus accumbens (NAc).…”

Dynorphin regulates the phagocytic activity of splenic phagocytes in wall lizards: involvement of a κ-opioid receptor-coupled adenylate-cyclase–cAMP–PKA pathway

“…Thus, it seems that, despite the species-specific differential effect, dynorphin(s) modulate the phagocytosis largely through opioid receptors -and particularly through -opioid receptors. It is noteworthy that cDNA for opioid receptors have not been cloned to date from any reptile tissue, although they have been cloned from immune as well as non-immune cells of fish (Darlison et al, 1997;Barrallo et al, 1998;Barrallo et al, 2000;Rodriguez et al, 2000;Alvarez et al, 2006;Chadzinska et al, 2009) and mammals (Chuang et al, 1994;Graveriaux et al, 1995;Sedqi et al, 1995;Sedqi et al, 1996;Sharp et al, 1997;Sharp et al, 2000). The sequence analysis of cDNA revealed that these receptors belong to the superfamily of G-protein-coupled receptors (Sharp et al, 1997;Law et al, 2000).…”

Bioinformatics and Evolution of Vertebrate Nociceptin and Opioid Receptors

“…The first full-length clone sequenced from a nonmammalian species was ccMOR from the brain of the white suckerfish, Catostomus commersoni (Darlison et al, 1997). Other nonmammalian species with full-length opioid receptors cloned are the zebrafish, Danio rerio, by Rodriguez and colleagues (Alvarez et al, 2006;Barrallo, González-Sarmiento, Alvar, & Rodriguez, 2000;Barrallo, González-Sarmiento, Porteros, Gracia-Isídoro, & Rodríguez, 1998;Porteros, Garcia-Isodoro, Barrallo, González-Sarmiento, & Rodriguez, 1999) and the rough-skinned newt, Taricha granulosa, in the laboratory of Moore (Bradford, Walthers, Searcy, & Moore, 2005;Bradford, Walthers, Stanley, Baugh, & Moore, 2006;. Using the same sets of primers that Evans group used in the first phylogenetic study of opioid receptors (Li et al, 1996b), our group was able to clone all four opioid receptor types expressed in R. pipiens brain tissue: rpMOR, rpDOR, rpKOR, and rpORL (Stevens, Brasel, & Mohan, 2007).…”