New lignan tyramide, phenolics, megastigmanes, and their glucosides from aerial parts of New Zealand spinach, Tetragonia tetragonoides

Choi, Hwan Seong; Cho, Jeong-Yong; Kim, Seon-Jae; Ham, Kyung‐Sik; Moon, Jae‐Hak

doi:10.1007/s10068-019-00700-x

Cited by 7 publications

(6 citation statements)

References 28 publications

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“…The halophyte T. tetragonioides is well adapted to an extreme environment and is also known to have the ability to remove salts from saline land [ 20 ]. New Zealand spinach is also consumed as a vegetable or in salads and used for medicinal purposes [ 21 ]. Bekmirzaev et al [ 22 ] observed a salt tolerance of T. tetragonioides up to 200 mM NaCl and a high potential for removing sodium ions from the soil.…”

Section: Introductionmentioning

confidence: 99%

Diversity and Plant Growth-Promoting Ability of Endophytic, Halotolerant Bacteria Associated with Tetragonia tetragonioides (Pall.) Kuntze

Egamberdieva

Alimov

Shurigin

et al. 2021

Plants

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The diversity of salt-tolerant cultivable endophytic bacteria associated with the halophyte New Zealand spinach (Tetragonia tetragonioides (Pall.) Kuntze) was studied, and their plant beneficial properties were evaluated. The bacteria isolated from leaves and roots belonged to Agrobacterium, Stenotrophomonas, Bacillus, Brevibacterium, Pseudomonas, Streptomyces, Pseudarthrobacter, Raoultella, Curtobacterium, and Pantoea. Isolates exhibited plant growth-promoting traits, including the production of a phytohormone (indole 3-acetic-acid), cell wall degrading enzymes, and hydrogen cyanide production. Furthermore, antifungal activity against the plant pathogenic fungi Fusarium solani, F. oxysporum, and Verticillium dahliae was detected. Ten out of twenty bacterial isolates were able to synthesize ACC deaminase, which plays a vital role in decreasing ethylene levels in plants. Regardless of the origin of isolated bacteria, root or leaf tissue, they stimulated plant root and shoot growth under 200 mM NaCl conditions. Our study suggests that halophytes such as New Zealand spinach are a promising source for isolating halotolerant plant-beneficial bacteria, which can be considered as potentially efficient biofertilizers in the bioremediation of salt-affected soils.

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Section: Introductionmentioning

confidence: 99%

Diversity and Plant Growth-Promoting Ability of Endophytic, Halotolerant Bacteria Associated with Tetragonia tetragonioides (Pall.) Kuntze

Egamberdieva

Alimov

Shurigin

et al. 2021

Plants

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“…Using mass spectrometry and NMR, 20 additional compounds of different structures were identified in T. tetragonioides: 15 phenolic compounds, one of which was identified for the first time; one acyl-galactopyranosyl-glycerol; four megastigmans and their glucosides [26]. As previously shown, megastigmans and their glucosides exhibit weak DPPH radical scavenging activity.…”

Section: Non-enzymatic Antioxidant Substances Of T Tetragonioidesmentioning

confidence: 86%

“…T. tetrag onioides can accumulate nonenzym atic antioxidant substances such as L-ascorbic acid, various flavonoids and lipophilic carotenoids [8,17,25,26], which are used in clinical practice and for the prevention of many diseases, including cardiovascular diseases. Among the bioactive compounds with antioxidant activity, flavonoids (Table 3) have the highest content in relation to 100 g raw weight of T. tetragonioides.…”

Section: Non-enzymatic Antioxidant Substances Of T Tetragonioidesmentioning

confidence: 99%

BIOACTIVE COMPOUNDS AND PHARMACOGNOSTIC POTENTIAL OF Tetragonia tetragonioides

Onoiko

2024

Biotechnol. acta

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In the recent years, due to the increasing resistance of pathogens to synthetic antimicrobial drugs, the use of highly active compounds from plants, which have proven their effectiveness in traditional medicine practices, is increased. Extracts of medicinal plants often contain a unique species ‒ specific combination of active ingredients that have a synergistic therapeutic effect. Therefore, the analysis of the biochemical composition of cultivated plants and the range of their potential biotechnological application is an urgent task. Aim. To summarize the information on the potential of the xerophytic plant Tetragonia tetragonioides as a source of functional food ingredients and biologically active substances that increase nonspecific organism resistance and contribute to the prevention and treatment of various diseases. Results. T. tetragonioides is a salt-tolerant and heat-resistant plant containing valuable nutrients and biologically active substances, a significant amount of vitamins, minerals, and dietary fibers. The high level of antioxidant compounds, especially flavonoids and carotenoids, helps to reduce the risk of degenerative pathologies developing associated with excessive oxidative stress. The unique complex of biologically active substances in T. tetragonioides, which includes 6-methoxyflavonols, predominantly derivatives of 6-methoxykaempferol, as well as megastigmanes and their glucosides, lignanamide, provides significant antioxidant, anti-inflammatory, antitumor, and antimicrobial activity and may be beneficial for the prevention of chronic diseases and age-related health problems. The effectiveness of T. tetragonioides has been demonstrated in animal models in the treatment of metabolic disorders such as obesity, hyperlipidemia, and hyperuricemia. Conclusions. T. tetragonioides, containing a specific complex of biologically active compounds, primarily 6-methoxyflavonols, may be a promising raw material for obtaining effective medications for the treatment and prevention of various chronic diseases and metabolic disorders.

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“…It is an edible vegetable that is high in vitamin K, vitamin B6 and C, and manganese. The plant contains phenolic compounds, including mainly flavonol glycosides and lignan amides [12,16,17]. In our previous studies, TTK was found rich in polyphenol (5.88 ± 0.32 mg/g) and flavonoids (4.34 ± 0.23 mg/g), and 6-methoxy-kaempferol-3-O-β-d-glucosyl(1" → 2")-β-d-glucopyranosyl-(6""-(E)-caffeoyl)-7-O-β-d-glucopyranoside (0.53 ± 0.003 mg/g), 6-methoxyflavonols (2-53 mg/g), and caffeic acid (0.32 ± 0.01) were detected as index compounds [13,17,18].…”

Section: Discussionmentioning

confidence: 99%

Tetragonia tetragonioides Protected against Memory Dysfunction by Elevating Hippocampal Amyloid-β Deposition through Potentiating Insulin Signaling and Altering Gut Microbiome Composition

Kim

Ryuk

et al. 2020

IJMS

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Alzheimer's disease (AD) is a progressive neurodegenerative disease. Herbal medicine may provide efficacious treatments for its prevention and/or cure. This study investigated whether a 70% ethanol extract of Tetragonia tetragonioides Kuntze (TTK; New Zealand spinach) improved the memory deficit by reducing hippocampal amyloid-β deposition and modulating the gut microbiota in rats with amyloid-β(25-35) infused into the hippocampus (AD rats) in an AD animal model. The AD rats had cellulose (AD-CON) or TTK (300 mg/kg bw; AD-TTK) in their high-fat diets for seven weeks. Rats with amyloid-β(35-25) infused into the hippocampus fed an AD-Con diet did not have memory loss (Normal-Con). AD-TTK protected against amyloid-β deposition compared to AD-Con, but it was higher than Normal-Con. AD-TTK protected against short-term and special memory loss measured by passive avoidance, Y maze, and water maze, compared to AD-Con. Compared to the Normal-Con, AD-Con attenuated hippocampal pCREB → pAkt → pGSK-3β, which was prevented in the AD-TTK group. Brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF) mRNA expression decreased in the AD-CON group, and their expression was prevented in the AD-TTK group. Hippocampal TNF-α and IL-1β mRNA expressions were higher in the AD-Con group than in the Normal-Con, and AD-TTK groups protected against the increase in their expression. The AD-CON group showed an increase in insulin resistance compared to the Normal-Con group and the AD-TTK group showed improvement. AD-Con separated the gut microbiome community compared to the Normal-Con group and AD-TTK overlapped with the normal-Con. The AD-Con group had more Clostridiales, Erysipelotrichales, and Desulfovibrionales than the AD-TKK and Normal-Con group but fewer Lactobacilales and Bacteroidales. In conclusion, the 70% ethanol extract of TTK enhanced the memory function and potentiated hippocampal insulin signaling, reduced insulin resistance, and improved gut microbiota in amyloid-β-infused rats.

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New lignan tyramide, phenolics, megastigmanes, and their glucosides from aerial parts of New Zealand spinach, Tetragonia tetragonoides

Cited by 7 publications

References 28 publications

Diversity and Plant Growth-Promoting Ability of Endophytic, Halotolerant Bacteria Associated with Tetragonia tetragonioides (Pall.) Kuntze

Diversity and Plant Growth-Promoting Ability of Endophytic, Halotolerant Bacteria Associated with Tetragonia tetragonioides (Pall.) Kuntze

BIOACTIVE COMPOUNDS AND PHARMACOGNOSTIC POTENTIAL OF Tetragonia tetragonioides

Tetragonia tetragonioides Protected against Memory Dysfunction by Elevating Hippocampal Amyloid-β Deposition through Potentiating Insulin Signaling and Altering Gut Microbiome Composition

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