New link between Parkinson's and Alzheimer's: Research uncovers the role of mutant leucine rich repeat kinase 2 and amyloid precursor protein

Same, Kaveh; Sherbaf, Farzaneh Ghazi; Aarabi, Mohammad Hadi

doi:10.1002/mds.27170

Cited by 1 publication

(1 citation statement)

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“…On the other hand, a direct interaction has been demonstrated between LRRK2 and the APP, since its intracellular domain (AICD) may be phosphorylated by the kinase. In fact, this phosphorylation regulates the transcriptional activity of the AICD in the nucleus after APP is processed by specific proteases [48,49].…”

Section: Main Mutations Leading To Inheritable Early-onset Ad But mentioning

confidence: 99%

Lessons on Differential Neuronal-Death-Vulnerability from Familial Cases of Parkinson’s and Alzheimer’s Diseases

Franco

Navarro

Martínez‐Pinilla

2019

IJMS

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The main risk of Alzheimer’s disease (AD) and Parkinson’s disease (PD), the two most common neurodegenerative pathologies, is aging. In contrast to sporadic cases, whose symptoms appear at >60 years of age, familial PD or familial AD affects younger individuals. Finding early biological markers of these diseases as well as efficacious treatments for both symptom relief and delaying disease progression are of paramount relevance. Familial early-onset PD/AD are due to genetic factors, sometimes a single mutation in a given gene. Both diseases have neuronal loss and abnormal accumulations of specific proteins in common, but in different brain regions. Despite shared features, the mechanisms underlying the pathophysiological processes are not known. This review aims at finding, among the genetic-associated cases of PD and AD, common trends that could be of interest to discover reliable biomarkers and efficacious therapies, especially those aimed at affording neuroprotection, i.e., the prevention of neuronal death.

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Section: Main Mutations Leading To Inheritable Early-onset Ad But mentioning

confidence: 99%

Lessons on Differential Neuronal-Death-Vulnerability from Familial Cases of Parkinson’s and Alzheimer’s Diseases

Franco

Navarro

Martínez‐Pinilla

2019

IJMS

View full text Add to dashboard Cite

show abstract

New link between Parkinson's and Alzheimer's: Research uncovers the role of mutant leucine rich repeat kinase 2 and amyloid precursor protein

Cited by 1 publication

References 4 publications

Lessons on Differential Neuronal-Death-Vulnerability from Familial Cases of Parkinson’s and Alzheimer’s Diseases

Lessons on Differential Neuronal-Death-Vulnerability from Familial Cases of Parkinson’s and Alzheimer’s Diseases

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