New Materials Based on Molecular Interaction between Hyaluronic Acid and Bovine Albumin

Gadomska, Magdalena; Musiał, Katarzyna; Bełdowski, Piotr; Sionkowska, Alina

doi:10.3390/molecules27154956

Cited by 6 publications

(2 citation statements)

References 46 publications

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“…Hyaluronic acid, a linear anionic polysaccharide, is a major macromolecular component of the extracellular matrix in the most connective tissues. Due to its biocompatible, biodegradable and bioresorbable nature, limited immunogenicity, recognized by cell surface receptors, its flexible and unique viscoelasticity properties, hyaluronic acid has been extensively studied in recent years for biomedical applications [162][163][164]. This biopolymer is useful in medicine for the treatment of diverse pathological situations such as arthritis but is also used in drug delivery and tissue engineering [165,166].…”

Section: Hyaluronic Acidmentioning

confidence: 99%

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Chelu,

Musuc

2023

Processes

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Biomaterials are mostly any natural and synthetic materials which are compatible from a biological point of view with the human body. Biomaterials are widely used to sustain, increase, reestablish or substitute the biological function of any injured tissue and organ from the human body. Additionally, biomaterials are uninterruptedly in contact with the human body, i.e., tissue, blood and biological fluids. For this reason, an essential feature of biomaterials is their biocompatibility. Consequently, this review summarizes the classification of different types of biomaterials based on their origin, as natural and synthetic ones. Moreover, the advanced applications in pharmaceutical and medical domains are highlighted based on the specific mechanical and physical properties of biomaterials, concerning their use. The high-priority challenges in the field of biomaterials are also discussed, especially those regarding the transfer and implementation of valuable scientific results in medical practice.

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Section: Hyaluronic Acidmentioning

confidence: 99%

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Chelu,

Musuc

2023

Processes

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“…List of the most common mucoadhesive and water-repellent polymers used to create buccal and sublingual tablets and films. The references related to the properties of the materials are the following [106,[122][123][124][125][126][127][128][129][130][131][132][133][134][135][136][137][138][139]. The column labeled "ref" identifies the previous literature, including creating a tablet or a film with the related material.…”

Section: Concept For Buccal Tablets For the Buccal Delivery Of Nanopa...mentioning

confidence: 99%

Concept for a Unidirectional Release Mucoadhesive Buccal Tablet for Oral Delivery of Antidiabetic Peptide Drugs Such as Insulin, Glucagon-like Peptide 1 (GLP-1), and their Analogs

Pratap-Singh,

Guo,

Baldelli

et al. 2023

Pharmaceutics

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Injectable peptides such as insulin, glucagon-like peptide 1 (GLP-1), and their agonists are being increasingly used for the treatment of diabetes. Currently, the most common route of administration is injection, which is linked to patient discomfort as well as being subjected to refrigerated storage and the requirement for efficient supply chain logistics. Buccal and sublingual routes are recognized as valid alternatives due to their high accessibility and easy administration. However, there can be several challenges, such as peptide selection, drug encapsulation, and delivery system design, which are linked to the enhancement of drug efficacy and efficiency. By using hydrophobic polymers that do not dissolve in saliva, and by using neutral or positively charged nanoparticles that show better adhesion to the negative charges generated by the sialic acid in the mucus, researchers have attempted to improve drug efficiency and efficacy in buccal delivery. Furthermore, unidirectional films and tablets seem to show the highest bioavailability as compared to sprays and other buccal delivery vehicles. This advantageous attribute can be attributed to their capability to mitigate the impact of saliva and inadvertent gastrointestinal enzymatic digestion, thereby minimizing drug loss. This is especially pertinent as these formulations ensure a more directed drug delivery trajectory, leading to heightened therapeutic outcomes. This communication describes the current state of the art with respect to the creation of nanoparticles containing peptides such as insulin, glucagon-like peptide 1 (GLP-1), and their agonists, and theorizes the production of mucoadhesive unidirectional release buccal tablets or films. Such an approach is more patient-friendly and can improve the lives of millions of diabetics around the world; in addition, these shelf-stable formulations ena a more environmentally friendly and sustainable supply chain network.

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Tribological behaviour of a synthetic synovial fluid and polyurethane in biomedical implants

Vries

Minnen²,

et al. 2023

Biotribology

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New Materials Based on Molecular Interaction between Hyaluronic Acid and Bovine Albumin

Cited by 6 publications

References 46 publications

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Concept for a Unidirectional Release Mucoadhesive Buccal Tablet for Oral Delivery of Antidiabetic Peptide Drugs Such as Insulin, Glucagon-like Peptide 1 (GLP-1), and their Analogs

Tribological behaviour of a synthetic synovial fluid and polyurethane in biomedical implants

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