New Meroterpenoids from the Endophytic Fungus Aspergillus flavipes AIL8 Derived from the Mangrove Plant Acanthus ilicifolius

Abstract

Four new meroterpenoids (2–5), along with three known analogues (1, 6, and 7) were isolated from mangrove plant Acanthus ilicifolius derived endophytic fungus Aspergillus flavipes. The structures of these compounds were elucidated by NMR and MS analysis, the configurations were assigned by CD data, and the stereochemistry of 1 was confirmed by X-ray crystallography analysis. A possible biogenetic pathway of compounds 1–7 was also proposed. All compounds were evaluated for antibacterial and cytotoxic activities.

Investigation of Marine-Derived Fungal Diversity and Their Exploitable Biological Activities

“…Three new phenolic bisabolance-type sesquiterpenoids, meroterpenoids, and aspergillides A–C were isolated from marine-derived Aspergillus sp. [ 17 ], A. flavipes [ 18 ], and A. ostianus [ 19 ], respectively. In particular, avrainvillamide was isolated from marine-derived Aspergillus sp.…”

Phyllomeroterpenoids A-C, Multi-biosynthetic Pathway Derived Meroterpenoids from the TCM Endophytic Fungus Phyllosticta sp. and their Antimicrobial Activities

“…Guignardone-type meroterpenoids are a rare kind of meroterpenoid that are composed of one C7 unit and one monoterpene unit derived from the pentose phosphate/terpenoid pathways 20 . Up to present, about 30 members 18 , 21 – 28 with tricyclic or tetracyclic skeletons have been reported from Guignardia sp. 18 , 21 – 26 , Pycnoporus sanguineus 27 , and Aspergillus sp.…”

“… 18 , 21 – 26 , Pycnoporus sanguineus 27 , and Aspergillus sp. 28 , and they showed antifungal 18 , antibacterial 23 , cytotoxic 25 , and Toll-Like Receptor 3 regulating activities 26 . Guignardianones are a special kind of fungal-derived benzylidene dioxolanone derived from the amino acid pathway 15 , 29 , 30 , and they exhibit antifungal 18 and antibacterial 31 activities.…”

Antibacterial Metabolites from the Sri Lankan Demosponge-Derived Fungus, <i>Aspergillus flavipes</i>

“…The fungi isolated in the current study could be either obligatory or facultative 'marine fungi', hence other than using the term marine fungi, referring to them as marine/sponge-derived fungi is more appropriate as we have not determined the origin. A. flavipes has been reported from both terrestrial and marine sources [20][21][22][23] . Therefore, whether A. flavipes isolated in this study is a facultative marine fungus, that has been accumulated through filter feeding or an obligatory marine fungus, which has originated in the internal tissues, is open to conjecture.…”