New method for preparation of delivery systems of poorly soluble drugs on the basis of functionalized mesoporous MCM-41 nanoparticles

Abstract

A b s t r a c tMCM-41 silica with spherical morphology and small particle sizes (100 nm) was synthesized and modified by post-synthesis method with amino and/or carboxylic groups. Solid state reaction was applied for the first time for loading of poorly soluble drug mesalazine (5-aminosalicylic acid -5-ASA). Thenon-loaded and drug loaded mesoporous silicas were characterized by XRD, TEM, N2 physisorption, elemental analysis, thermal analysis, FT-IR and solid state NMR spectroscopy. Quantum-chemical calculations were used to predict the interactions between the drug molecule and the functional groups of the carrier. The nanoparticles were post-coated with sodium alginate and the coating modified the rate of mesalazine release from MCM-41NH 2 and MCM-41NH 2 COOH particles. Cytotoxic evaluation on colon adenocarcinoma cell line revealed that the alginate coating reduced cytotoxicity of mesalazine loaded in the post-coated particles compared to the pure mesalazine. The functionalized, polymer coated mesoporous systems are suitable oral drug delivery systems providing an opportunity to modify drug release.

pH-controlled Release System for Curcumin based on Functionalized Dendritic Mesoporous Silica Nanoparticles

“…Significant decrease of the surface area, pore volume and pore size of the functionalized and Cur-loaded samples compared to the calcined materials confirms, that the drug molecules indeed filled pore spaces ( Figure 2 and Table 1). These results agreed with the previous studies [44][45][46][47].…”

“…The C-N stretching vibration is normally observed in range of 1000-1200 cm -1 , however, due to the overlay with the IR absorptions of Si-O-Si in the range 1130-1000 cm -1 and of Si-CH2-R in the range 1250-1200 cm -1 , this peak was not observed in this region [54]. A peak at 1556 cm -1 was attributed to the symmetrical protonated form of amino groups (-NH 3 + ) bending, which confirmed the existence of amine groups [44,50]. Nevertheless, the peak in this region for the amine-modified samples with APTES is broader, indicating possible overlap of peaks.…”

Experimental and theoretical study of quercetin complexes formed on pure silica and Zn-modified mesoporous MCM-41 and SBA-16 materials

“…The appropriate chemical surface modification of the mesoporous matrix is essential because the silanol groups of the silica surface are not selective enough to adsorb drug molecules with different functionalities [20]. Application of mesoporous materials as carriers can solve some problems related with the low solubility and poor bioavailability of the bioactive molecules [21]. Thus, loading of flavanols in nanoporous silica systems can stabilize and protect them from degradation, ensuring high loading capacity [22][23][24][25][26][27].…”

Development of New Bexarotene-loaded Mesoporous Silica Systems for Topical Pharmaceutical Formulations

“…The high specific surface area (>1000 m 2 /g), large pore volume (~ 1.0-2.0 cm 3 /g), and consequently the high sorption/hosting capacity for bioactive molecules, the relative simple, inexpensive, environmentally friendly and controllable synthesis procedure, the biocompatibility and lack of toxicity, explain the particular interest reflected in a large number of publications worldwide. Thus, pure or modified MCM-41 mesoporous silica was used as carrier for various types of drugs, such as ibuprofen, 6 aspirin, 7,8 naproxen, 9 doxorubicin, 10 captopril, 11 erythromycin, 12 celecoxib, 13 econazole nitrate, 14 famotidine, 15 mesalazine, 16 tetracycline, 17 alendronate, 18,19 curcumin, 20,21 folic acid, 22 etc. More information can be found in exhaustive investigation on drug release from silica-based ordered mesoporous materials, reported by Maria Vallet-Regi et.…”