New Method of Preparing Gelatin Microcapsules of Soluble Pharmaceuticals

Madan, P. L.; Jani, Rupalben Kaushalkumar; Bartilucci, Andrew J.

doi:10.1002/jps.2600670338

Cited by 22 publications

(1 citation statement)

References 9 publications

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“…For oilin-water (O/W) emulsion preparation, the polymer is usually dissolved in an organic solvent and the drug is dissolved or dispersed. The size and the shape of the particles depend on the emulsifier concentration, stirring rate and the volume of the organic phase [9] . Successful microencapsulation of lipid-soluble drugs such as steroids [10] , topical anesthetics [11] , bleomycin sulfate [12] , doxorubicin [13] , naltrexone, and promethazine [14] has been reported.…”

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confidence: 99%

Formulation of Enalapril-Loaded Microspheres Using Emulsion Solvent Evaporation Technique for Bitter Taste Masking

Gvozdeva¹,

Kassarova²,

Pilicheva³

2022

IJPS

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The aim of the present study was to formulate polymer microspheres using the emulsion solvent evaporation technique as an approach to mask the bitter taste of enalapril maleate. Five models were prepared with two water-insoluble polymers. Talc was used to stabilize the particle structure. Production yields ranged from 38 % to 53 %; drug loading varied between 17 % and 40 %; the mean particle size ranged from 140 µm to 339 µm. No interaction between enalapril and the polymers was estimated. A drug release study in artificial saliva indicated a negligible amount of enalapril dissolved in the test medium which demonstrated successful taste masking.

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confidence: 99%

Formulation of Enalapril-Loaded Microspheres Using Emulsion Solvent Evaporation Technique for Bitter Taste Masking

Gvozdeva¹,

Kassarova²,

Pilicheva³

2022

IJPS

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Standardization of a newly designed vibrating capillary apparatus for the preparation of microcapsules

1993

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Vibrating capillary apparatus (VCA) was designed and constructed for the preparation of sulphamethoxazole (SMZ) microcapsules using gelatin as a coating polymer. The microcapsules were characterized by physico-chemical methods. The apparent diffusion coefficient D, and diffusion rate constant K B L of the drug were measured at pH of 1.2 and 7.2. Better controlled release products were obtained in the VCA.

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