New Method to Calculate Creatinine Generation Rate Using Pre‐ and Postdialysis Creatinine Concentra tions

Abstract

: The creatinine (Cr) generation rate reflects the muscle mass, a possible indicator of protein nutritional status. Thus, in this study, we developed equations for calculating the Cr generation rate. Depner and Daugirdas recently developed a method for determining the protein catabolic rate (PCR) from the pre‐ and postdialysis blood urea nitrogen concentrations. We modified their method to develop equations for calculating the total Cr generation rate from the measured predialysis Cr concentration and estimated postrebound concentration. The total Cr generation rate is defined as the sum of the intrinsic Cr generation rate and the extrinsic Cr generation rate (i.e., the generation rate of Cr derived from food). In the pre sent study, the postrebound Cr concentration was estimated on the basis of postdialysis Cr concentration and the KN for Cr. The intrinsic Cr generation rate was obtained by subtracting the extrinsic Cr generation rate, which was estimated on the basis of the PCR, from the total Cr generation rate calculated. The intrinsic Cr generation rate determined with this method was virtually the same as that obtained using the postrebound Cr concentration, the concentration immediately before the next hemodialysis (HD) session, and the PCR. The intrinsic Cr generation rate determined with the present method did not vary with changes in the HD prescription (i.e., with an increase in blood flow rate, a prolongation of the HD duration time, or a change in dialyzer membrane area). The present study also indicated that the intrinsic Cr generation rate de creased with age in both males and females.

High-Performance Membrane Dialyzers and Mortality in Hemodialysis Patients: A 2-Year Cohort Study from the Annual Survey of the Japanese Renal Data Registry

“…Blood samples were drawn and assayed at each dialysis center, typically within 24 h of the sample being taken, and the most recent values, including serum albumin, hemoglobin, calcium, phosphate, C-reactive protein (CRP), β 2 MG, dialysis dose, normalized protein catabolic rate (nPCR), and % creatinine generation rate (%CGR), at the time of survey were collected [14,15]. The dialysis dose was measured by using single-pool Kt/V for urea (Kt/V) [8,16].…”

Effects of L-carnitine supplementation on nutritional, immunological, and cardiac parameters in hemodialysis patients: a pilot study

“…We determined normalized protein catabolic rate (nPCR) and percentile creatinine generation rate (%CGR), which can estimate dietary protein intake and skeletal muscle mass, respectively [7,10].…”

Low serum sodium concentration is a prognostic factor related to current blood glucose level in stable hemodialysis patients: an observational study

“…Sodium concentration and interdialytic weight gain (the percentage of body weight gain/dry weight) were the average of the values in the first HD session of the first week in April, May, and June 2005. Kt/V, normalized protein catabolic rate (n-PCR) and creatinine generation rate (CGR) were calculated according to the formula of Shinzato [15,16]. Serum calcium concentration was adjusted for serum albumin according to the equation: corrected Ca = measured Ca + (4.0 -serum albumin in g/dL) [17].…”