2019
DOI: 10.1016/j.molstruc.2019.04.033
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New organic extractant based on pyridazinone scaffold compounds: Liquid-liquid extraction study and DFT calculations

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Cited by 19 publications
(5 citation statements)
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“…Pyridazin-3(2H)-ones are an important family of heterocycles because of their great chemical reactivity (Chelfi et al, 2015;Zarrouk et al, 2010), with new products reported recently (Chakraborty et al, 2018;El Kalai et al, 2019a). In addition, the importance of pyridazinones in medicinal chemistry has increased in recent years thanks to their pharmacological properties, including anticancer (Yarden & Caldes, 2013), antihypertensive (Siddiqui et al, 2011), antibacterial (Akhtar et al, 2016), anti-HIV (Livermore et al, 1993), anti-inflammatory (Singh et al, 2017), antidepressant (Boukharsa et al, 2016), anti-convulsant (Partap et al, 2018) and cardiotonic (Costas et al, 2015) activities.…”
Section: Chemical Contextmentioning
confidence: 99%
“…Pyridazin-3(2H)-ones are an important family of heterocycles because of their great chemical reactivity (Chelfi et al, 2015;Zarrouk et al, 2010), with new products reported recently (Chakraborty et al, 2018;El Kalai et al, 2019a). In addition, the importance of pyridazinones in medicinal chemistry has increased in recent years thanks to their pharmacological properties, including anticancer (Yarden & Caldes, 2013), antihypertensive (Siddiqui et al, 2011), antibacterial (Akhtar et al, 2016), anti-HIV (Livermore et al, 1993), anti-inflammatory (Singh et al, 2017), antidepressant (Boukharsa et al, 2016), anti-convulsant (Partap et al, 2018) and cardiotonic (Costas et al, 2015) activities.…”
Section: Chemical Contextmentioning
confidence: 99%
“…Pyridazinone derivatives are important biologically active heterocyclic compounds (Dubey et al, 2015;Akhtar et al, 2016), which have been the subject of many studies because of their widespread biological activities, such as inflammatory (Barberot et al, 2018), antibacterial (El-Hashash et al, 2014), antidepressant (Boukharsa et al, 2016), antihypertensive (Demirayak et al, 2004), anti-HIV (Li et al, 2013), anticonvulsant (Partap et al, 2018), and their use as herbicidal agents (Asif, 2013). In addition, it has been shown that pyridazinones are good corrosion inhibitors (Chetouani et al, 2003) and that they can be used as organic extractants of certain metal ions in the aqueous phase (El Kalai et al, 2019b).…”
Section: Chemical Contextmentioning
confidence: 99%
“…1 ). Furthermore, many studies have shown that pyridazinones are good corrosion inhibitors [20] and that they can be used as organic extractants of certain metal ions in the aqueous phase [21] . Due to the numerous biological and therapeutic properties of the pyridazin-3( 2H )-ones, the synthesis and investigation of new pyridazinone derivatives have attracted considerable attention from researchers and have been the subject of many studies such as physical, chemical, spectroscopic, and pharmacological properties [22] , [23] , [24] , [25] .…”
Section: Introductionmentioning
confidence: 99%
“…These techniques have become very reliable in predicting the properties of molecules with great precision [26] , [27] , [28] , [29] , [30] . In a continuation of our efforts to obtain new pyridazin-3( 2H )-one compounds [ 21 , [31] , [32] , [33] ], we were inspired to design and synthesize ( E )−4-(4-methylbenzyl)−6-styrylpyridazin-3( 2H )-one ( MBSP ). The chemical structure attributed to the title molecule was characterized using FT-IR, UV–vis, 1 H NMR, 13 C NMR, ESI-MS, and the ( E )-configuration was confirmed by single-crystal X-ray diffraction.…”
Section: Introductionmentioning
confidence: 99%