New Paradigm for a Targeted Cancer Therapeutic Approach: A Short Review on Potential Synergy of Gold Nanoparticles and Cold Atmospheric Plasma

Aryal, Sajesan; Bisht, Gunjan

doi:10.3390/biomedicines5030038

Cited by 35 publications

(23 citation statements)

References 39 publications

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“…Several studies by others and us have observed plasma-induced tumor cell death before [82][83][84][85][86][87][88][89][90][91][92][93][94][95][96][97][98]. Kumar and colleagues observed in several pancreatic cancer cell lines an increase in apoptosis concomitant with downregulation of MAPK7, BCL2, and CHK1 [99].…”

Section: Discussionmentioning

confidence: 94%

Activation of Murine Immune Cells upon Co-culture with Plasma-treated B16F10 Melanoma Cells

et al. 2019

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Recent advances in melanoma therapy increased median survival in patients. However, death rates are still high, motivating the need of novel avenues in melanoma treatment. Cold physical plasma expels a cocktail of reactive species that have been suggested for cancer treatment. High species concentrations can be used to exploit apoptotic redox signaling pathways in tumor cells. Moreover, an immune-stimulatory role of plasma treatment, as well as plasma-killed tumor cells, was recently proposed, but studies using primary immune cells are scarce. To this end, we investigated the role of plasma-treated murine B16F10 melanoma cells in modulating murine immune cells’ activation and marker profile. Melanoma cells exposed to plasma showed reduced metabolic and migratory activity, and an increased release of danger signals (ATP, CXCL1). This led to an altered cytokine profile with interleukin-1β (IL-1β) and CCL4 being significantly increased in plasma-treated mono- and co-cultures with immune cells. In T cells, plasma-treated melanoma cells induced extracellular signal-regulated Kinase (ERK) phosphorylation and increased CD28 expression, suggesting their activation. In monocytes, CD115 expression was elevated as a marker for activation. In summary, here we provide proof of concept that plasma-killed tumor cells are recognized immunologically, and that plasma exerts stimulating effects on immune cells alone.

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Section: Discussionmentioning

confidence: 94%

Activation of Murine Immune Cells upon Co-culture with Plasma-treated B16F10 Melanoma Cells

et al. 2019

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“…Furthermore, prior to the clinical application of CAP, several technical parameters need to be studied in more detail, including penetration depth, optimal dosage, and repetitive applications. Also, recent evidence suggests a potential synergy of nanoparticles in combination with CAP that leads to a maximized targeted efficacy [ 120 ]. At the same time, the killing efficacy of plasma should be tested on chemoresistant cancer cells.…”

Section: Clinical Prospects and Conclusionmentioning

confidence: 99%

Cold Atmospheric Plasma in the Treatment of Osteosarcoma

Gümbel

Bekeschus

Gelbrich

et al. 2017

IJMS

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Human osteosarcoma (OS) is the most common primary malignant bone tumor occurring most commonly in adolescents and young adults. Major improvements in disease-free survival have been achieved by implementing a combination therapy consisting of radical surgical resection of the tumor and systemic multi-agent chemotherapy. However, long-term survival remains poor, so novel targeted therapies to improve outcomes for patients with osteosarcoma remains an area of active research. This includes immunotherapy, photodynamic therapy, or treatment with nanoparticles. Cold atmospheric plasma (CAP), a highly reactive (partially) ionized physical state, has been shown to inherit a significant anticancer capacity, leading to a new field in medicine called “plasma oncology.” The current article summarizes the potential of CAP in the treatment of human OS and reviews the underlying molecular mode of action.

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“…The excellent stability of GNP stabilized with thiolated ligands permits chemical reactions directly on their surface . The ligands used to stabilize GNP may be specifically chosen for drug encapsulation and release, or to target specific tissues, such as tumors …”

Section: Introductionmentioning

confidence: 99%

Gold nanoparticles in ophthalmology

Masse

Ouellette

Lamoureux

et al. 2018

Medicinal Research Reviews

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Many research projects are underway to improve the diagnosis and therapy in ophthalmology. Indeed, visual acuity deficits affect 285 million people worldwide and different strategies are being developed to strengthen patient care. One of these strategies is the use of gold nanoparticles (GNP) for their multiple properties and their ability to be used as both diagnosis and therapy tools. This review exhaustively details research developing GNPs for use in ophthalmology. The toxicity of GNPs and their distribution in the eye are described through in vitro and in vivo studies. All publications addressing the pharmacokinetics of GNPs administered in the eye are extensively reviewed. In addition, their use as biosensors or for imaging with optical coherence tomography is illustrated. The future of GNPs for ophthalmic therapy is also discussed. GNPs can be used to deliver genes or drugs through different administration routes. Their antiangiogenic and anti-inflammatory properties are of great interest for different ocular pathologies. Finally, GNPs can be used to improve stereotactic radiosurgery, brachytherapy, and photothermal therapy because of their many properties.

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New Paradigm for a Targeted Cancer Therapeutic Approach: A Short Review on Potential Synergy of Gold Nanoparticles and Cold Atmospheric Plasma

Cited by 35 publications

References 39 publications

Activation of Murine Immune Cells upon Co-culture with Plasma-treated B16F10 Melanoma Cells

Activation of Murine Immune Cells upon Co-culture with Plasma-treated B16F10 Melanoma Cells

Cold Atmospheric Plasma in the Treatment of Osteosarcoma

Gold nanoparticles in ophthalmology

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