2020
DOI: 10.3389/fendo.2019.00929
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New Perspective in Diabetic Neuropathy: From the Periphery to the Brain, a Call for Early Detection, and Precision Medicine

Abstract: Diabetic peripheral neuropathy (DPN) is a common chronic complication of diabetes mellitus. It leads to distressing and expensive clinical sequelae such as foot ulceration, leg amputation, and neuropathic pain (painful-DPN). Unfortunately, DPN is often diagnosed late when irreversible nerve injury has occurred and its first presentation may be with a diabetic foot ulcer. Several novel diagnostic techniques are available which may supplement clinical assessment and aid the early detection of DPN. Moreover, trea… Show more

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Cited by 106 publications
(73 citation statements)
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“…Other serious complications include: leg ulcers that can eventually end in leg amputation. [1][2][3][4][5]20,21 DPN is classified into numerous types and subtypes based on a mixture of phenomenological, aetiological, pathological and neurophysiological parameters. 1,[22][23][24] In a retrospective study, like the present one, it is difficult to assure the reliability of information on the details of these types or subtypes and be confident that such information has been documented in every patient.…”
Section: Discussionmentioning
confidence: 99%
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“…Other serious complications include: leg ulcers that can eventually end in leg amputation. [1][2][3][4][5]20,21 DPN is classified into numerous types and subtypes based on a mixture of phenomenological, aetiological, pathological and neurophysiological parameters. 1,[22][23][24] In a retrospective study, like the present one, it is difficult to assure the reliability of information on the details of these types or subtypes and be confident that such information has been documented in every patient.…”
Section: Discussionmentioning
confidence: 99%
“…The close association between DPN and modifiable cardiovascular risk factors (cardiometabolic disease) including elevated triglyceride levels (hyperlipidemia), body mass index (BMI), smoking, hypertension and cardiovascular disease was documented repeatedly in previous studies. 1,20,21,24,42 However, no specific mechanisms linking DPN with cardiovascular disease have been suggested in any of these studies.…”
Section: Dovepressmentioning
confidence: 99%
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“…These transporters belong to the family of solute carriers (SLCs) Both these transporters facilitate absorption of thiamine in micromolar to nanomolar range from the intestinal lumen and follow saturation kinetics principles. These transporters are also expressed in other tissues such as pancreas, kidney, and brain [8], which facilitates free thiamine transport into the tissues [9][10][11][12]. The results of the gene expression will be presented in the consequent article.…”
Section: Resultsmentioning
confidence: 99%
“…It is a life-threatening disorder that involves both peripheral and autonomic nerves, affecting more than 50% of the diabetic population [80]. To date, our understanding of the pathophysiology of DNP remains elusive [81]. The role of epigenetics in this disease has been suggested recently.…”
Section: Diabetic Neuropathymentioning
confidence: 99%