New Perspectives in the Study of Intestinal Inflammation: Focus on the Resolution of Inflammation

Camba-Gómez, Miguel; Gualillo, Oreste; Conde, Javier

doi:10.3390/ijms22052605

Cited by 16 publications

(4 citation statements)

References 122 publications

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“…Making a definitive diagnosis and monitoring disease activity using current methods is not easy, and these tasks usually take a significant amount of time [32]. Despite various therapeutic treatments (biological treatment, steroid therapy, and immunosuppression), some patients do not respond positively to treatment or become immune to the drugs used in their treatment [32][33][34].…”

Section: Discussionmentioning

confidence: 99%

Calprotectin Is Associated with HETE and HODE Acids in Inflammatory Bowel Diseases

Szczuko,

Komisarska,

Kikut

et al. 2023

JCM

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Background: Intestinal diseases are identified as autoimmune phenomena attributed to a specific virus that binds to the mucosal epithelium. The importance of precise diagnostic processes and identification is emphasized, but the multifaceted and complex etiological factors pose challenges for effective treatment. A recent supplementary study suggested a linkage between the secretion of calprotectin, a protein associated with inflammatory processes, and increased levels of hydroxyeicosatrienoic acids (HETE) and hydroxyoctadecadienoic (HODE) compounds. Methods: Sixty-two patients (average age: 14.06 ± 2.93 years) suffering from inflammatory bowel diseases were included in this study. Comparative analyses were performed to assess the concentrations of calprotectin against the levels of arachidonic acid derivatives. The calprotectin concentration was determined using the enzyme-linked immunosorbent assay (ELISA) method. The derivatives of HETE and HODE were identified through liquid chromatography. Results: Patients with Crohn’s disease (CD) displayed higher average concentrations of fatty acid metabolites; however, no correlation with calprotectin was observed. A dependency of 12S HETE concentration relative to age was noted in the CD group, and a similar trend was also identified in ulcerative colitis (UC), with the significant metabolites being 15 HETE and 5 oxoETE. In UC patients, a positive correlation was established between the calprotectin concentration and the acids 5-HETE and 12-HETE. Conclusions: These findings may be instrumental for monitoring the inflammatory states of patients and indicating a pathway for intervention. The metabolite 16RS HETE is associated with UC activity, and 15-HETE is related to the disease’s duration. A relatively more significant role of HETE acids in the progression of the disease was observed in UC.

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Section: Discussionmentioning

confidence: 99%

Calprotectin Is Associated with HETE and HODE Acids in Inflammatory Bowel Diseases

Szczuko,

Komisarska,

Kikut

et al. 2023

JCM

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“…In present study, the significantly increased gene expression of TNF-α and IL-1β suggested SA successfully triggered inflammatory response on IECs of turbot. Generally speaking, acute inflammatory response is essential for tissue homoeostasis, however, if the inflammation cannot be resolved, it will develop chronic inflammation, which gives rise to many chronic inflammatory diseases [26] , [27] , [28] . NaBT, the sodium salt of butyrate, is a kind of potential anti-inflammatory substance.…”

Section: Discussionmentioning

confidence: 99%

In vitro study of sodium butyrate on soyasaponin challenged intestinal epithelial cells of turbot (Scophthalmus maximus L.) refer to inflammation, apoptosis and antioxidant enzymes

et al. 2021

Fish and Shellfish Immunology Reports

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“…In addition, some patients do not respond to treatment at all or lose response to the drug over time; hence, there is a constant need to search for new therapeutic strategies in IBD. Therefore, as noted by Camba-Gomez et al, new therapeutic options based on a reduction in inflammation through the use of, e.g., pro-resolving mediators should be developed [ 15 , 16 ]. So far, it has been established that a higher long-term intake of omega 3 polyunsaturated fatty acids (PUFAs, n-3) is associated with a lower risk of UC in adult women [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Involvement of Proinflammatory Arachidonic Acid (ARA) Derivatives in Crohn’s Disease (CD) and Ulcerative Colitis (UC)

Kikut

Mokrzycka

Drozd

et al. 2022

JCM

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Recently, an increase in the incidence of inflammatory bowel disease (IBD) has been observed, especially among children and adolescents. Currently, few studies focus on the differentiation of inflammation in IBD subunits, i.e., Crohn’s Disease (CD) and Ulcerative Colitis (UC). The aim of this study was to compare the concentrations of proinflammatory mediators of arachidonic acid (ARA) and linoleic acid (LA) in patients with CD (n = 34) and UC (n = 30), in order to identify differences in inflammation in both diseases and within the same entity, according to disease activity. Sixty-four adolescents with a mean age of 13.76 ± 2.69 and 14.15 ± 3.31, for CD and UC, respectively, were enrolled in the study. Biochemical analysis of ARA and LA derivatives was performed using a liquid chromatography. A trend was observed in the concentration of 15S-HETE (hydroxyeicosatetraenoic acids) in CD relative to UC. The active phase of both diseases showed a higher 15S-HETE concentration in active CD relative to active UC. Comparing patients with CD with active and inactive disease showed a trend of increased levels of thromboxane B2, leukotriene B4 and 9S-HODE (hydroxyoctadecadienoic acid) in the active versus the inactive disease. We also observed statistically significantly higher levels of 12S-HETE in inactive CD relative to active CD. In the UC group, on the other hand, statistically significantly higher levels of prostaglandin E2 and 16RS-HETE were observed in active UC relative to inactive UC. Moreover, significantly higher concentrations of LTX A4 5S, 6R were observed in inactive UC relative to the active phase. In conclusion, the present study indicated the activity of the 15-LOX pathway in CD. Further studies involving lipid mediators in patients with IBD may contribute to the development of new therapies for the treatment of IBD. The identification of differences in the course of inflammation may help to target therapy in CD and UC, and perhaps allow the introduction of an additional diagnostic marker between the two main IBD subtypes.

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New Perspectives in the Study of Intestinal Inflammation: Focus on the Resolution of Inflammation

Cited by 16 publications

References 122 publications

Calprotectin Is Associated with HETE and HODE Acids in Inflammatory Bowel Diseases

Calprotectin Is Associated with HETE and HODE Acids in Inflammatory Bowel Diseases

In vitro study of sodium butyrate on soyasaponin challenged intestinal epithelial cells of turbot (Scophthalmus maximus L.) refer to inflammation, apoptosis and antioxidant enzymes

Involvement of Proinflammatory Arachidonic Acid (ARA) Derivatives in Crohn’s Disease (CD) and Ulcerative Colitis (UC)

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