New perspectives on the endothelin axis in pain

Barr, Travis P.; Kam, Sarah A.; Khodorova, Alla; Montmayeur, Jean-Pierre; Strichartz, Gary R.

doi:10.1016/j.phrs.2011.02.002

Cited by 35 publications

(25 citation statements)

References 107 publications

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“…30,31 In this study, we show that SMIR-operated rats from POD3 to POD28 developed a marked plantar responsiveness to mechanical stimulus (Fig. 1), which was consistent with the original study, prominent mechanical allodynia in rats arose 3 days after animals had received SMIR surgery and was maintained for up to 22 days.…”

Section: High-frequency Tens Suppresses the Progression Of Smir-evokesupporting

confidence: 90%

High-Frequency Transcutaneous Electrical Nerve Stimulation Attenuates Postsurgical Pain and Inhibits Excess Substance P in Rat Dorsal Root Ganglion

Chen

Tzeng

Lin

et al. 2014

Regional Anesthesia and Pain Medicine

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BackgroundTranscutaneous electrical nerve stimulation (TENS) is a common therapeutic modality for pain management, but its effectiveness in skin/muscle incision and retraction (SMIR)–evoked pain is unknown. We aimed to examine the effects of TENS on postoperative pain and the levels of substance P (SP), N-methyl-D-aspartate receptor 1 (NR1), and interleukin 1β (IL-1β) in rat dorsal root ganglion (DRG).MethodsHigh-frequency (100 Hz) TENS was administered daily beginning on postoperative day 1 (POD1) and continued until animal subjects were killed for tissues. Mechanical sensitivity to von Frey stimuli (6g and 15g) and the levels of NR1, SP, and IL-1β in DRG were assessed in the sham-operated, SMIR-operated, TENS after SMIR surgery, and placebo-TENS after SMIR surgery groups.ResultsSkin/muscle incision and retraction rats exhibited a significant hypersensitivity to von Frey stimuli on POD3. In contrast with SMIR rats, SMIR-operated rats receiving TENS therapy demonstrated a rapid recovery of mechanical hypersensitivity. The SMIR-operated rats showed an up-regulation of NR1, SP, and IL-1β in DRG on PODs 14 and 28, whereas the SMIR-operated rats after TENS administration reversed this up-regulation. By contrast, the placebo-TENS after SMIR operation did not alter postsurgical pain nor the levels of NR1, SP, and IL-1β.ConclusionsOur data demonstrated that TENS intervention reduced persistent postoperative pain caused by SMIR operation. Up-regulation of NR1, SP, and IL-1β in DRG, activated after SMIR surgery, is important in the development of prolonged postincisional pain. The TENS pain relief may be related to the suppression of NR1, SP, and IL-1β in DRG of SMIR rats.

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Section: High-frequency Tens Suppresses the Progression Of Smir-evokesupporting

confidence: 90%

High-Frequency Transcutaneous Electrical Nerve Stimulation Attenuates Postsurgical Pain and Inhibits Excess Substance P in Rat Dorsal Root Ganglion

Chen

Tzeng

Lin

et al. 2014

Regional Anesthesia and Pain Medicine

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“…In the past decade, ample evidence was obtained in support of a pathological role of ET-1 in pain processing associated with various types of inflammatory and non-inflammatory painful conditions, including arthritis, cancer and neuropathies (Barr et al, 2011;Imhof et al, 2011;Hans et al, 2009;Werner et al, 2010;Khodorova et al, 2009a). It has been suggested that ET-1 produced peripherally can participate in the promotion of both acute and chronic pain by acting on ET A receptor, though these effects are limited by ET B receptor activation (Khodorova et al, 2009a).…”

Section: Discussionmentioning

confidence: 99%

“…The baseline sensitivity level of pain sensation of the 8-12-week-old naïve GET-1 (n = 25) and TET-1 (n = 25) mice and their NTg controls (n = 25) (body weight 25-30 g) were assessed by measuring the nociceptive thresholds to tactile and radiant heat stimuli by von Frey filament (Barr et al, 2011) and Hargreaves' test (Held et al, 1998), respectively. Briefly, the tactile threshold was determined by applying a punctate stimulus to the skin of the plantar surface of the hind paw using a calibrated von Frey filament (IITC Life Science, Inc., USA) in which 50% of mice showed hind paw withdrawal.…”

Section: Baseline Measurement Of Pain Sensationsmentioning

confidence: 99%

Over-expression of endothelin-1 in astrocytes, but not endothelial cells, ameliorates inflammatory pain response after formalin injection

et al. 2012

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“…Consistent with ET-induced excitation of sensory neurons, administration of ET-1 caused painlike behavior in rats, and the effect was antagonized by BQ123, an ET A antagonist (66) . This action of ET-1 suggests a novel role of ETs, potentiating transduction of pain signals in somatosensory systems (67,68) . ET B receptors are the prominent type in the brain.…”

Section: Et Receptors In the Brainmentioning

confidence: 92%

Endothelin systems in the brain: involvement in pathophysiological responses of damaged nerve tissues

Kōyama

2013

BioMolecular Concepts

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In addition to their potent vasoconstriction effects, endothelins (ETs) show multiple actions in various tissues including the brain. The brain contains high levels of ETs, and their production is stimulated in many brain disorders. Accumulating evidence indicates that activation of brain ET receptors is involved in several pathophysiological responses in damaged brains. In this article, the roles of brain ET systems in relation to brain disorders are reviewed. In the acute phase of stroke, prolonged vasospasm of cerebral arteries and brain edema occur, both of which aggravate brain damage. Studies using ET antagonists show that activation of ETA receptors in the brain vascular smooth muscle induces vasospasm after stroke. Brain edema is induced by increased activity of vascular permeability factors, such as vascular endothelial growth factor and matrix metalloproteinases. Activation of ETB receptors stimulates astrocytic production of these permeability factors. Increases in reactive astrocytes are observed in neurodegenerative diseases and in the chronic phase of stroke, where they facilitate the repair of damaged nerve tissues by releasing neurotrophic factors. ETs promote the induction of reactive astrocytes through ETB receptors. ETs also stimulate the production of astrocytic neurotrophic factors. Recent studies have shown high expression of ETB receptors in neural progenitors. Activation of ETB receptors in neural progenitors promotes their proliferation and migration, suggesting roles for ETB receptors in neurogenesis. Much effort has been invested in the pursuit of novel drugs to induce protection or repair of damaged nerve tissues. From these studies, the pharmacological significance of brain ET systems as a possible target of neuroprotective drugs is anticipated.

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New perspectives on the endothelin axis in pain

Cited by 35 publications

References 107 publications

High-Frequency Transcutaneous Electrical Nerve Stimulation Attenuates Postsurgical Pain and Inhibits Excess Substance P in Rat Dorsal Root Ganglion

High-Frequency Transcutaneous Electrical Nerve Stimulation Attenuates Postsurgical Pain and Inhibits Excess Substance P in Rat Dorsal Root Ganglion

Over-expression of endothelin-1 in astrocytes, but not endothelial cells, ameliorates inflammatory pain response after formalin injection

Endothelin systems in the brain: involvement in pathophysiological responses of damaged nerve tissues

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