This study aims to solve the problem of unbalanced regional economic development in Jiangsu and deeply excavates the relevant theories of regional logistics and the unbalanced spatial situation. The classification of regional logistics and spatial disequilibrium and the dimensions involved are studied. At present, the development status of Jiangsu logistics has locked the main reason for the unbalanced situation of the regional logistics space in Jiangsu. The basic principles, application scope, and methods of Bagging and Boosting algorithms are deeply studied. Then, the Jiangsu logistics space nonequilibrium situation assessment model is established based on the Bagging and Boosting algorithms, and the input data is sorted and summarized. Finally, the results are obtained through experiments evaluating the model and analyzed and summarized. The core issues, the factors affecting development, and the uneven development situation have been comprehensively assessed. The conclusion drawn is as follows: the imbalance of the logistics productivity of various regions in Jiangsu will inevitably lead to the imbalance of the regional logistics space in Jiangsu, which affects the coordinated and healthy development of the regional logistics in Jiangsu. These conclusions are significant to the inherent causes and effects of regional logistics spatial disequilibrium and can promote the coordination, synergy, and common development of Jiangsu logistics regions.