New Polyether Macrocycles as Promising Antitumor Agents─Targeted Synthesis and Induction of Mitochondrial Apoptosis
Ilgiz I. Islamov,
Lilya U. Dzhemileva,
Ilgam V. Gaisin
et al.
Abstract:A series of previously unknown aromatic polyether macrodiolides containing a cis,cis-1,5-diene moiety in the molecule were synthesized in 47−74% yields. Macrocycle compounds were first obtained by intermolecular esterification of aromatic polyether diols with α,ω-alka-nZ,(n+4)Z-dienedioic acids mediated by N-(3-(dimethylamino)propyl)-N′-ethylcarbodiimide hydrochloride (EDC•HCl) and 4-(dimethylamino)pyridine (DMAP). For the synthesized compounds, studies of cytotoxicity on tumor (Jurkat, K562, U937), conditiona… Show more
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