New Polysiloxane Surfaces Modified with &amp;lt;i&amp;gt;ortho-, meta-&amp;lt;/i&amp;gt; or &amp;lt;i&amp;gt;para&amp;lt;/i&amp;gt;-Nitrophenyl Receptors for Copper Adsorption

Radi, Smaail; Basbas, Nouraddine; Tighadouini, Saïd; Bacquet, Maryse

doi:10.4236/jsemat.2014.41004

Cited by 8 publications

(6 citation statements)

References 30 publications

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“…It was expected, as they have a similar chemical composition. On the FTIR spectra, the weak bands around 2800-300 cm −1 indicate C-H bond stretching, corresponding to the carbon chain attached to the inorganic silica matrix [27,28]. This indicates the C8 and C18 carbon chains attached to the silica particle.…”

Section: Materials Characterizationmentioning

confidence: 99%

Packed in‐tube SPME–LC–MS/MS for fast and straightforward analysis of cannabinoids and metabolites in human urine

et al. 2022

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Cannabinoids are pharmacologically active compounds present in cannabis plants, which have become important research topics in the modern toxicological and medical research fields. Not only is cannabis the most used drug globally, but also cannabinoids have a growing use to treat a series of diseases. Therefore, new, fast, and efficient analytical methods for analyzing these substances in different matrices are demanded. This study developed a new packed-in-tube solid-phase microextraction (IT-SPME) method coupled to liquid chromatography with tandem mass spectrometry (LC-MS/MS), for the automated microextraction of seven cannabinoids from human urine. Packed IT-SPME microcolumns were prepared in (508 µm i.d. × 50 mm) stainless-steel hardware; each one required only 12 mg of sorbent phase. Different sorbents were evaluated; fractional factorial design 2 4−1 and a central composite design were employed for microextraction optimization. Under optimized conditions, the developed method was a fast and straightforward approach. Only 250 µl of urine sample was needed, and no hydrolysis was required. The sample pretreatment included only dilution and centrifugation steps (8 min), whereas the complete IT-SPME-LC-MS/MS method took another 12 min, with a sample throughput of 3 samples h −1 . The developed method presented adequate precision, accuracy and linearity; R 2 values ranged from 0.990 to 0.997, in the range of 10-1000 ng ml −1 . The lower limits of quantification varied from 10 to 25 ng ml −1 . Finally, the method was successfully applied to analyze 20 actual urine samples, and the IT-SPME microcolumn was reused over 150 times.

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Section: Materials Characterizationmentioning

confidence: 99%

Packed in‐tube SPME–LC–MS/MS for fast and straightforward analysis of cannabinoids and metabolites in human urine

et al. 2022

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“…The entire ATR-FTIR spectra (4000–500 cm −1 ) ( Figure S2 ) and spectrum (4000–500 cm −1 ) of commercial ASNase from E. coli used in this work ( Figure S3 ) are depicted in the Supplementary Materials . The broad band showed in all the spectra of the materials and bioconjugates, between 1100 and 1000 cm −1 , can be attributed to the presence of siloxane groups (Si–O–Si) of silica, as given in Figure 2 (dashed grey line) [ 45 ]. The broad band shown in the spectra of ASNase-[Si][N 3114 ]Cl, ASNase-[Si][N 3222 ]Cl, and ASNase-[Si][N 3888 ]Cl between 1700 and 1600 cm −1 , in contrast with the spectra of [Si][N 3114 ]Cl, [Si][N 3222 ]Cl, and [Si][N 3888 ]Cl, is attributed to the presence of ASNase ( Figure 2 , dashed yellow line).…”

Section: Resultsmentioning

confidence: 99%

Enhanced Enzyme Reuse through the Bioconjugation of L-Asparaginase and Silica-Based Supported Ionic Liquid-like Phase Materials

et al. 2022

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L-asparaginase (ASNase) is an amidohydrolase that can be used as a biopharmaceutical, as an agent for acrylamide reduction, and as an active molecule for L-asparagine detection. However, its free form displays some limitations, such as the enzyme’s single use and low stability. Hence, immobilization is one of the most effective tools for enzyme recovery and reuse. Silica is a promising material due to its low-cost, biological compatibility, and tunable physicochemical characteristics if properly functionalized. Ionic liquids (ILs) are designer compounds that allow the tailoring of their physicochemical properties for a given task. If properly designed, bioconjugates combine the features of the selected ILs with those of the support used, enabling the simple recovery and reuse of the enzyme. In this work, silica-based supported ionic liquid-like phase (SSILLP) materials with quaternary ammoniums and chloride as the counterion were studied as novel supports for ASNase immobilization since it has been reported that ammonium ILs have beneficial effects on enzyme stability. SSILLP materials were characterized by elemental analysis and zeta potential. The immobilization process was studied and the pH effect, enzyme/support ratio, and contact time were optimized regarding the ASNase enzymatic activity. ASNase–SSILLP bioconjugates were characterized by ATR-FTIR. The bioconjugates displayed promising potential since [Si][N3444]Cl, [Si][N3666]Cl, and [Si][N3888]Cl recovered more than 92% of the initial ASNase activity under the optimized immobilization conditions (pH 8, 6 × 10−3 mg of ASNase per mg of SSILLP material, and 60 min). The ASNase–SSILLP bioconjugates showed more enhanced enzyme reuse than reported for other materials and immobilization methods, allowing five cycles of reaction while keeping more than 75% of the initial immobilized ASNase activity. According to molecular docking studies, the main interactions established between ASNase and SSILLP materials correspond to hydrophobic interactions. Overall, it is here demonstrated that SSILLP materials are efficient supports for ASNase, paving the way for their use in the pharmaceutical and food industries.

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“…This research involves the modification of porous SiO 2 with functional ortho-, meta-or para-nitrophenyl receptors using heterogeneous route that involves reaction of carbaldehyde derivatives with 3-aminopropyl trimethoxysilane prior to immobilization on the support [16].…”

Section: Preparation Of Silica-immobilized Propylamine (Sinh 2 )mentioning

confidence: 99%

“…All materials characterizations like SEM, NMR, UV-Vis, TGA, BET have been studied and published before [16].…”

Section: Materials Characterizationmentioning

confidence: 99%

New Polysiloxane Surfaces Modified with Ortho-, Meta-, or Para-Nitrophenyl Moieties for Cadmium Removal from Water

Jodeh¹,

Khalaf²,

Radi³

et al. 2016

JSEMAT

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This study aims to prepare and develop several vehicles chelation polydentate supported ligands and then installed it using sol-gel or polymerization or to be susceptible to imply conjunction with the highly toxic heavy metal ions in the water, and disrupted the underground water used for drinking or agriculture, including cadmium ions. As the process of interaction between ligands and heavy metals depends on the circumstances of surrounding conditions which are treated in this research. Metal ion uptake through complexation or hydrogels can be affected by hydrophilichydrophobic balance, the nature of chelate ligands and the extent of cross-linking of macromolecular supports. Ligand function also dictates reactivity, complexation ability and efficiency of polymer supported ligands in the present case expected to be good solution for such problem. This research involves the synthesis and characterization of new polysiloxane surfaces modified with ortho-, meta-, or para-nitrophenyl moieties. The resulting adsorbents have been characterized by SEM, IR, UV, 13 C solid state NMR, BET surface area, B.J.H. pore sizes, TGA and nitrogen adsorption-desorption isotherm. These porous materials showed a very good thermal and chemical stability and hence they can be used as perfect adsorbents to uptake toxic heavy metal ions including Cd(II) from groundwater. The concentrations of each adsorbate in the filtrate were determined using Atomic Absorption Spectrophotometer. The results showed that all of the three resulting products had high adsorption efficiency. Also, it showed strong complexation properties with heavy metal ions.

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New Polysiloxane Surfaces Modified with <i>ortho-, meta-</i> or <i>para</i>-Nitrophenyl Receptors for Copper Adsorption

Cited by 8 publications

References 30 publications

Packed in‐tube SPME–LC–MS/MS for fast and straightforward analysis of cannabinoids and metabolites in human urine

Packed in‐tube SPME–LC–MS/MS for fast and straightforward analysis of cannabinoids and metabolites in human urine

Enhanced Enzyme Reuse through the Bioconjugation of L-Asparaginase and Silica-Based Supported Ionic Liquid-like Phase Materials

New Polysiloxane Surfaces Modified with Ortho-, Meta-, or Para-Nitrophenyl Moieties for Cadmium Removal from Water

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