New Polyurethane Nail Lacquers for the Delivery of Terbinafine: Formulation and Antifungal Activity Evaluation

Valdes, Barbara S. Gregorí; Serro, Ana Paula; Gordo, P.M.; Silva, Alexandra; Gonçalves, Lídia; Salgado, Ana; Marto, Joana; Baltazar, Diogo; Santos, Rui Galhano dos; Bordado, João; Ribeiro, Helena Margarida

doi:10.1016/j.xphs.2017.02.017

Cited by 28 publications

(16 citation statements)

References 33 publications

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“…Tagat ® CH 60 (PEG-60 Hydrogenated Castor Oil) was purchased from Evonik (Essen, Germany). PU 19 was synthesized in laboratory of Superior Technical Institute, Universidade de Lisboa and the procedure was performed according a previous published work [19]. Ciclopirox was obtained from Fagron Iberica (Barcelona, Spain), Ony-Tec ® was from Laboratorio Medea, Reig Jofre (Barcelona, Spain).…”

Section: Methodsmentioning

confidence: 99%

“…The PU 19, a polyurethane containing isophorone diisocyanate (IPDI) and polypropylene glycol (PPG) and d -isosorbide (6:1:5), was the polymer selected for preparing 5 different nail lacquer formulations containing 1% of drug (TH or CPX) [19]. Different polymer concentrations (10%, 15%, 20% and 25%) were employed.…”

Section: Methodsmentioning

confidence: 99%

“…To evaluate the influence of different concentrations of polymer, an in vitro release study was performed using Franz diffusion cell apparatus through a hydrofilic membrane (Tuffryn ® Membrane, Pall corporation) (Portsmouth, UK), with a diffusion area of 1 cm 2 for 6 h [20] and according a previous reported work [19]. The data obtained from in vitro release studies were fitted to different kinetic models:…”

Section: Methodsmentioning

confidence: 99%

“…The determination of wettability by measurement of contact angle and the viscosity measurement were performed according a previous reported work [19].…”

Section: Methodsmentioning

confidence: 99%

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Polyurethanes as New Excipients in Nail Therapeutics

et al. 2018

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Onychomycosis affects about 15% of the population. This disease causes physical and psychosocial discomfort to infected patients. Topical treatment (creams, solutions, gels, colloidal carriers, and nail lacquers) is usually the most commonly required due to the high toxicity of oral drugs. Currently, the most common topical formulations (creams and lotions) present a low drug delivery to the nail infection. Nail lacquers appear to increase drug delivery and simultaneously improve the effectiveness of treatment with increased patient compliance. These formulations leave a polymer film on the nail plate after solvent evaporation. The duration of the film residence in the nail constitutes an important property of nail lacquer formulation. In this study, a polyurethane polymer was used to delivery antifungals drugs, such as terbinafine hydrochloride (TH) and ciclopirox olamine (CPX) and the influence of its concentration on the properties of nail lacquer formulations was assessed. The nail lacquer containing the lowest polymer concentration (10%) was the most effective regarding the in vitro release, permeation, and antifungal activity. It has also been demonstrated that the application of PU-based nail lacquer improves the nail plate, making it smooth and uniform and reduces the porosity contributing to the greater effectiveness of these vehicles. To conclude, the use of polyurethane in nail formulations is promising for nail therapeutics.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…The determination of wettability by measurement of contact angle and the viscosity measurement were performed according a previous reported work [19].…”

Section: Methodsmentioning

confidence: 99%

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Polyurethanes as New Excipients in Nail Therapeutics

et al. 2018

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“…The biocompatibility of the polymer was evaluated in vitro by direct contact with cells, following the ISO 10993-5:2009 recommendation guidelines [ 25 ]. The procedure used was a previously published [11].…”

Section: In Vitro Cytotoxicity Assaymentioning

confidence: 99%

New Biocompatible Polyurethanes: Synthesis, Structural Characterization and Cytotoxicity

Valdes¹,

Gomes²,

Gomes³

et al. 2018

Preprint

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The synthesis of four samples of new polyurethanes was evaluated by changing the ratio of the diol monomers used, poly(propylene glycol) (PPG) and D-isosorbide, in the presence of aliphatic isocyanates such as the isophorone diisocyanate (IPDI) and 4,4′-methylenebis(cyclohexyl isocyanate) (HMDI). The thermal properties of the four polymers obtained were determined by DSC, exhibiting Tg values in the range 55-70 ºC, and their molecular structure characterized by FTIR, 1H and 13C NMR spectroscopies. The diffusion coefficients of these polymers in solution were measured by the Pulse Gradient Spin Echo (PGSE) NMR method, enabling the calculation of the corresponding hydrodynamic radii in diluted solution (1.62–2.65 nm). The molecular weights were determined by GPC/SEC and compared with the values determined by quantitative 13C NMR analysis. Finally, the biocompatibility of the polyurethanes was assessed using the HaCaT keratinocyte cell line by the MTT reduction assay method showing values superior to 70% cell viability.

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Glycerin‐Based Polyurethane Obtained by Inverse Emulsion: Comparison Between Magnetic Induction and Conventional Heating

Santiago

Silva

Marques

et al. 2018

Macromolecular Symposia

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This work studies the comparison of polyurethane particles obtained by heating through magnetic induction and conventional heating. The collected materials are characterized by Fourier transform infrared spectroscopy, Low‐Field Nuclear Magnetic Resonance Spectroscopy, Scanning Electron Microscopy, Particle Size Distribution, and Gel Fraction. Besides that, the magnetic force of the magnetite in glycerin suspension is performed. The obtained results allow inferring that the polyurethane particles obtained by magnetic induction exhibit properties close to the particles obtained by conventional heating. However, composite particles present a longer relaxation time than the one of the polyurethane, providing the highest toughness to the material. As the principal advantage, materials obtained by magnetic induction heating can be produced in a fraction of the time requested for the preparation of the similar materials obtained by conventional heating.

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New Polyurethane Nail Lacquers for the Delivery of Terbinafine: Formulation and Antifungal Activity Evaluation

Cited by 28 publications

References 33 publications

Polyurethanes as New Excipients in Nail Therapeutics

Polyurethanes as New Excipients in Nail Therapeutics

New Biocompatible Polyurethanes: Synthesis, Structural Characterization and Cytotoxicity

Glycerin‐Based Polyurethane Obtained by Inverse Emulsion: Comparison Between Magnetic Induction and Conventional Heating

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