New primary renal diagnosis codes for the ERA-EDTA

Venkat‐Raman, Gopalakrishnan; Tomson, Charles; Gao, Yongsheng; Cornet, Ronald; Stengel, Bénédicte; Grönhagen‐Riska, Carola; Reid, C. P. P.; Jacquelinet, Christian; Schaeffner, Elke; Boeschoten, Els W.; Casino, Francesco Gaetano; Collart, Frédéric; Meester, Johan De; Zurriaga, Óscar; Kramar, Reinhard; Jager, Kitty J.; Simpson, Keith

doi:10.1093/ndt/gfs461

Cited by 101 publications

(71 citation statements)

References 10 publications

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“…Moreover, accurate coding of primary renal diagnose could not be verified retrospectively, because no renal biopsy data were available. Indeed, although the French thesaurus seems more comprehensive than the ERA-EDTA Study diagnostic codes (33,34), it might not have corresponded exactly to the evolving classification of MGs. Another pitfall is the possible overlap of MGs: there can be multiple causes of ESRD in a single patient with MM or ALA. Also, patients considered as having ESRD but recovering renal function during the follow-up had, in fact, prolonged AKI.…”

Section: Discussionmentioning

confidence: 99%

Trends in Survival and Renal Recovery in Patients with Multiple Myeloma or Light-Chain Amyloidosis on Chronic Dialysis

Decourt¹,

Gondouin²,

Delaroziere

et al. 2016

Clinical Journal of the American Society of Nephrology

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Background and objectives Monoclonal gammopathies (MGs) with renal involvement can lead to ESRD caused by myeloma cast nephropathy (MCN), immunoglobulin light chain amyloidosis (ALA), or light-chain deposition disease (LCDD). Few studies have focused on the prognosis of patients with MG on chronic dialysis. We evaluated the outcomes of patients with MG incident on chronic dialysis in France.Design, setting, participants, & measurements All incident patients registered in the Renal Epidemiology and Information Network Registry between 2002 and 2011 with ESRD caused by ALA, LCDD, or MCN were included. Patient's survival, censored for renal transplantation, renal recovery, and loss to follow-up, as well as renal outcomes were analyzed and compared with a control group. Risk factors and causes of death were analyzed.Results We included 1459 patients, comprising 265 (18%) patients with ALA, 334 (23%) patients with LCDD, and 861 (59%) patients with MCN. Median age was 72 years, and 56% were men. Median follow-up was 13.1 months. Renal recovery was observed in 9.1% of patients and more frequent after 2006. Kidney transplantation was rare in this population (2.3%). Among 1272 patients who remained on dialysis, 67% died. Median survival on dialysis was 18.3 months. Main causes of death were malignancies (34.4%), cardiovascular diseases (18%), infections (13.3%), and cachexia (5.2%). Independent risk factors of death were age (hazard ratio [HR], 1.03 per year increase; 95% confidence interval [95% CI], 1.02 to 1.03), frailty (HR, 1.93; 95% CI, 1.58 to 2.36), congestive heart failure (HR, 1.54; 95% CI, 1.23 to 1.93), and dialysis initiation on a central catheter (HR, 1.40; 95% CI, 1.11 to 1.75). Factors associated with a lower risk of death were year of dialysis initiation (HR, 0.95 per year increase; 95% CI, 0.91 to 0.99) and high BP (HR, 0.80; 95% CI, 0.67 to 0.97).Conclusions Survival of patients with ALA, LCDD, or MCN on chronic dialysis is poor but has improved over time. Progressive malignancy is the main cause of death in this population. Renal recovery has increased since 2006.

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Section: Discussionmentioning

confidence: 99%

Trends in Survival and Renal Recovery in Patients with Multiple Myeloma or Light-Chain Amyloidosis on Chronic Dialysis

Decourt¹,

Gondouin²,

Delaroziere

et al. 2016

Clinical Journal of the American Society of Nephrology

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“…A mixture of old and new (2012) ERA-EDTA codes for primary diagnoses [2] were received from centres. The split was about 50 : 50 for 2014 incident patients.…”

Section: Methodsmentioning

confidence: 99%

UK Renal Registry 18th Annual Report: Chapter 1 UK Renal Replacement Therapy Incidence in 2014: National and Centre-specific Analyses

Gilg¹,

Caskey²,

Fogarty³

2016

Nephron

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“…The patient-reported etiology of kidney disease was validated by cross-referencing the reported etiology of kidney disease in their medical records or kidney biopsy reports, if available. Etiology of kidney disease was categorized into 6 major categories based on the ERA-EDTA coding system [13]: familial/hereditary nephropathy, congenital anomalies of the kidney and urinary tract (including reflux nephropathy and congenital hypoplasia/dysplasia of the kidneys), glomerular disease, tubulo-interstitial kidney disease, systemic diseases affecting the kidney and miscellaneous renal disorders. Etiology of kidney disease was classified according to the physician-stated diagnosis in the patient's medical records or diagnosis as per renal biopsy report.…”

Section: Methodsmentioning

confidence: 99%

The Irish Kidney Gene Project - Prevalence of Family History in Patients with Kidney Disease in Ireland

Connaughton

Bukhari

Cassidy

et al. 2015

Nephron

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Background: The prevalence of kidney disease (KD) due to inherited genetic conditions in Ireland is unknown. The aim of this study was to characterise an adult kidney disease population in Ireland and to identify familial clusters of kidney disease within the population. Methods: This was a multicenter cross-sectional study of patients with kidney disease in the Republic of Ireland, from January 2014 to September 2014, recruiting from dialysis units and out-patient renal departments. A survey was performed by collecting data on etiology of kidney disease and whether a family history of kidney disease exists. Medical records were cross-referenced to confirm the etiology of kidney disease. Results: A total of 1,840 patients were recruited with a mean age of 55.9 years (range 17-94.5) and a male predominance (n = 1,095; 59.5%). A positive family history was reported by 629 participants (34.2%). Excluding polycystic kidney disease (n = 134, 7.3%), a positive family history was reported by 495 participants (26.9%). Kidney disease due to an unknown etiology was the commonest etiology in the non-polycystic kidney disease group with a positive family history (10.6%, n = 67). Kidney diseases that are not classically associated with familial inheritance including tubulo-interstitial kidney disease, congenital abnormalities of the kidney and urinary tract and glomerulonephritis demonstrated familial clustering. Conclusion: In an Irish non-polycystic kidney disease population, 26.9% reports a positive family history. The commonest etiology of kidney disease in the positive family history cohort, excluding autosomal dominant polycystic kidney disease, was kidney disease due to unknown etiology. Examining families with kidney disease provides an opportunity to better understand disease pathogenesis and potentially identify genetic predispositions to kidney disease.

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New primary renal diagnosis codes for the ERA-EDTA

Cited by 101 publications

References 10 publications

Trends in Survival and Renal Recovery in Patients with Multiple Myeloma or Light-Chain Amyloidosis on Chronic Dialysis

Trends in Survival and Renal Recovery in Patients with Multiple Myeloma or Light-Chain Amyloidosis on Chronic Dialysis

UK Renal Registry 18th Annual Report: Chapter 1 UK Renal Replacement Therapy Incidence in 2014: National and Centre-specific Analyses

The Irish Kidney Gene Project - Prevalence of Family History in Patients with Kidney Disease in Ireland

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