New Procedure for the Total Synthesis of Cilostamide

Seyedi, Seyed Mohammad; Sadeghian, Hamid; Arghiani, Zahra

doi:10.1515/hc.2008.14.3.183

Search citation statements

Order By: Relevance

Paper Sections

Select...

N-cyclohexyl-n-methyl-4-((3-oxo-34-dihydro-2hbenzo[b][14]oxa...1

Compound (2v′)1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(2 citation statements)

References 26 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The title compound was prepared according to the general reported papers [24] .The product was purified by flash chromatography (PE/EA = 3/1) to give 2p, total yield :48%. mp.…”

Section: N-cyclohexyl-n-methyl-4-((3-oxo-34-dihydro-2hbenzo[b][14]oxa...mentioning

confidence: 99%

See 1 more Smart Citation

Photo-Induced Electrophilic Aromatic Substitution of Ferric Acyl Nitrene

Zong,

Bai,

Qiu

et al. 2023

Synthesis

View full text Add to dashboard Cite

A photo-induced intramolecular electron-aromatic-substitution (SEAr) of N-acyloxybenzozmide under 20 mol% FeCl3 at 1, 4-dioxane is reported for the synthesis of biologically interesting benzoxazin-3(4H)-ones. In the reaction, it is believed that blue LED facilitates the reaction, like reaction temperature serving as source of energy. The reaction SEAr pathway was ascribed to the electron effect in aryl ring of substrates. The reaction was also applicable for the synthesis of useful scaffolds possessing a quinolin-2-one core, such as anticancer reagent 4, brexipiprazole and cilostamide analogues.

show abstract

“…The title compound was prepared according to the general reported papers [24] .The product was purified by flash chromatography (PE/EA = 3/1) to give 2p, total yield :48%. mp.…”

Section: N-cyclohexyl-n-methyl-4-((3-oxo-34-dihydro-2hbenzo[b][14]oxa...mentioning

confidence: 99%

“…The resulting mixture was refluxed at 100 °C for 7 h and the cooled solution was purified by silica gel column chromatography to afford product 4 (66 mg, 56%). Yield: 39% over three steps; 24,25…”

Section: Compound (2v′)mentioning

confidence: 99%