New pyranonaphthazarin and 2-naphthoic acid derivatives from the mangrove endophytic fungus Leptosphaerulina sp. SKS032

Cui, Hui; Liu, Yena; Ding, Meng; Zhang, Zhengrui; Liu, Huiting; Huang, Xishan; She, Zhigang

doi:10.1016/j.phytol.2017.05.010

Cited by 21 publications

(16 citation statements)

References 20 publications

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“…isolated from the mangrove plant Acanthus ilicifolius. The fungus was reported to produce novel compounds pyranonaphthazarin and 2naphthoic acid derivatives having strong antimicrobial properties against S. aureus (Cui et al, 2017). DeMon XIV was characterized as Cladosporium sp.…”

Section: Discussionmentioning

confidence: 99%

Identification of endophytic fungi from roots of two Dendrobium species and evaluation of their antibacterial property

Shrestha¹,

Shah²,

Pan³

2018

Afr. J. Microbiol. Res.

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Among all orchids, Dendrobium sp. is considered to have high medicinal value. Dendrobium moniliforme and Dendrobium transparens have immense pharmaceutical, commercial potentiality. However, their fungal endophytes remain unexplored. Isolation and identification of thirteen species of endophytic fungi from the root of D. moniliforme as well as five species from the roots of D. transparens were done. The two endophytic fungi namely Aspergillus flavus and Trichoderma harzianum were common for both plant species. Antimicrobial assay was done against selected human pathogen both gram positive and negative Escherichia coli, Pseudomanas aeruginosa, Staphyllococcus aureus and Staphyllococcus epidermidis. The antimicrobial assay showed the significant role of endophytic fungi to inhibit the bacterial growth. Methanolic extract of DeMon VI and DeMon X were prepared to identify the bioactive compounds. Phenolic and 3-Eicosene,(E)-compounds were identified from extract of DeMon VI whereas Pentadecanoic acid, 14 methyle-, methyl ester and Diethyl Phthalate were identified from extract of DeMon X.

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Section: Discussionmentioning

confidence: 99%

Identification of endophytic fungi from roots of two Dendrobium species and evaluation of their antibacterial property

Shrestha¹,

Shah²,

Pan³

2018

Afr. J. Microbiol. Res.

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“…42 A Phomopsis strain yielded one new naphthoquinone 595 , 238 whilst a Leptosphaerulina strain yielded the antibacterial leptospyranonaphthazarin A ( 596 ). 261 Three new ethylnaphthoquinone derivatives, neofusnaphthoquinone A ( 597 ), 6-(1-methoxylethy1)-2,7-dimethoxyjuglone ( 598 ), and (3 R ,4 R )-3-methoxyl-botryosphaerone D ( 599 ), were obtained from a Neofusicoccum strain by bioassay-guided fractionation. This is the first time reported a naphthoquinone dimer 597 with inhibitory effect against indoleamine 2,3-dioxygenase (IDO) with an IC 50 value of 1.47 μM in vitro .…”

Section: Secondary Metabolites From Mangrove Fungimentioning

confidence: 99%

Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities

et al. 2022

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“…Leptosnaphthoic acid A ( 278 ), was isolated from an endophytic fungus Leptosphaerulina sp. SKS032, which exhibited antibacterial activity against Staphylococcus aureus with an MIC value of 50.0 μg/mL [ 74 ].…”

Section: New Mnps From the Beibu Gulfmentioning

confidence: 99%

“…SKS032. In the antibiotic assay, compound 342 exhibited antibacterial activity against Staphylococcus aureus with an MIC value of 25.0 μg/mL [ 74 ]. The mangrove endophytic fungus Aspergillus terreus (No.…”

Section: New Mnps From the Beibu Gulfmentioning

confidence: 99%

Marine Natural Products from the Beibu Gulf: Sources, Chemistry, and Bioactivities

et al. 2023

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Marine natural products (MNPs) play an important role in the discovery and development of new drugs. The Beibu Gulf of South China Sea harbors four representative marine ecosystems, including coral reefs, mangroves, seaweed beds, and coastal wetlands, which are rich in underexplored marine biological resources that produce a plethora of diversified MNPs. In our ongoing efforts to discover novel and biologically active MNPs from the Beibu Gulf, we provide a systematic overview of the sources, chemical structures, and bioactive properties of a total of 477 new MNPs derived from the Beibu Gulf, citing 133 references and covering the literature from the first report in November 2003 up to September 2022. These reviewed MNPs were structurally classified into polyketides (43%), terpenoids (40%), nitrogen-containing compounds (12%), and glucosides (5%), which mainly originated from microorganisms (52%) and macroorganisms (48%). Notably, they were predominantly found with cytotoxic, antibacterial, and anti-inflammatory activities. This review will shed light on these untapped Beibu Gulf-derived MNPs as promising lead compounds for the development of new drugs.

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New pyranonaphthazarin and 2-naphthoic acid derivatives from the mangrove endophytic fungus Leptosphaerulina sp. SKS032

Cited by 21 publications

References 20 publications

Identification of endophytic fungi from roots of two Dendrobium species and evaluation of their antibacterial property

Identification of endophytic fungi from roots of two Dendrobium species and evaluation of their antibacterial property

Secondary metabolites from mangrove-associated fungi: source, chemistry and bioactivities

Marine Natural Products from the Beibu Gulf: Sources, Chemistry, and Bioactivities

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