New pyrazolylindolin-2-one based coumarin derivatives as anti-melanoma agents: design, synthesis, dual BRAF^V600E/VEGFR-2 inhibition, and computational studies

Abstract

New pyrazolylindolin-2-one linked coumarin derivatives were designed as dual BRAFV600E/VEGFR-2 inhibitors targeting melanoma cells A375. Docking simulation showed various interactions with the binding residues in BRAFV600E and VEGFR-2 active sites.

Design, synthesis and computational studies of new azaheterocyclic coumarin derivatives as anti-Mycobacterium tuberculosis agents targeting enoyl acyl carrier protein reductase (InhA)

“…Coumarin scaffold is a widely recognized naturally derived chemical backbone in the field of medicinal chemistry, exhibiting a diverse array of biological effects, such as anticancer, 23,24 anti-inflammatory, 25,26 antioxidant, 27,28 antimicrobial, 29,30 and, particularly, antitubercular, such as InhA inhibitory agents. 31–35 In recent years, several coumarin scaffolds have been reported for their potent anti-TB activities ( Fig.…”