2024
DOI: 10.1002/ardp.202400081
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New pyridine‐based chalcones and pyrazolines with anticancer, antibacterial, and antiplasmodial activities

Jonathan Ramírez‐Prada,
Juan S. Rocha‐Ortiz,
Marta I. Orozco
et al.

Abstract: New pyridine‐based chalcones 4a–h and pyrazolines 5a–h (N‐acetyl), 6a–h (N‐phenyl), and 7a–h (N‐4‐chlorophenyl) were synthesized and evaluated by the National Cancer Institute (NCI) against 60 different human cancer cell lines. Pyrazolines 6a, 6c–h, and 7a–h satisfied the pre‐determined threshold inhibition criteria, obtaining that compounds 6c and 6f exhibited high antiproliferative activity, reaching submicromolar GI50 values from 0.38 to 0.45 μM, respectively. Moreover, compound 7g (4‐CH3) exhibited the hig… Show more

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