New pyridine-containing non-cyclic and macrocyclic Schiff bases: synthesis and interferon-inducing activity

Lozytska, R.; Kryzhanovsky, Danyla; Gorodniuk, Viktor; Кузьмин, В. Е.; Lozitsky, Viktor; Fedchuck, Alla; Рыбалко, С. Л.; Diadiun, S. T.; Eynde, Jean Jacques Vanden

doi:10.3998/ark.5550190.0005.e13

Cited by 5 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of azomethine groups in Schiff compounds is significant for their biological and medicinal properties, particularly their antibacterial activity. This property has been documented in numerous studies, highlighting the potential of Schiff bases in pharmaceutical applications 6–10 . The ease of synthesis and versatility of Schiff bases make them valuable entities in organic chemistry, with promising applications in drug development.…”

Section: Introductionmentioning

confidence: 91%

“…This property has been documented in numerous studies, highlighting the potential of Schiff bases in pharmaceutical applications. [6][7][8][9][10] The ease of synthesis and versatility of Schiff bases make them valuable entities in organic chemistry, with promising applications in drug development. Thus, Schiff bases demonstrate a diverse range of biological activities and medicinal applications, as evidenced by their potential roles in antibacterial, 11 antioxidant, 12 DNA binding affinity, 13 antiinflammatory, 14 antifungal, 15 anticancer, [16][17][18] as well as antidiabetic and antimicrobial activities.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Probing the variations of synthesis, antimicrobial activity, and optical properties of new lanthanide and transition metal complexes of salicylaldehyde‐dipropylenetriamine ligand

Ebqa'ai,

Reed,

Seni

et al. 2024

Applied Organom Chemis

View full text Add to dashboard Cite

Due to their notable antimicrobial activity and optical properties, Schiff base ligands, along with their lanthanide and transition metal complexes, have seen extensive use in various applications. However, despite their potential, a comprehensive investigation into lanthanide and transition metal complexes using the same Schiff base ligand has not been reported to date. In this study, coordination compounds of lanthanide and transition metal ions were synthesized from the Schiff base ligand salicylaldehyde‐dipropylenetriamine. These complexes were characterized by elemental analysis, 1H and 13C NMR, mass spectroscopy, Fourier‐transform infrared spectroscopy ultraviolet–visible spectroscopy (UV–Vis), fluorescence spectroscopy, molar conductivity measurements, and thermogravimetric studies. Furthermore, the molecular structure of the Co (II) complex was determined by means of X‐ray crystallography. Thermogravimetric studies illustrated endothermic and non‐spontaneous degradation pathways of the complexes. UV–Vis spectra showed a new absorption band attributed to the ligand‐to‐metal charge transfer peak supporting the complexation between the ligand and metals. The lanthanide complexes exhibited distinctive luminescence emissions in the Sm (III), Tb (III), and Eu (III) complexes. This observation suggests that the ligand possesses the capability to absorb and efficiently transfer energy to the metal center of these lanthanide ions, thereby resulting in their characteristic luminescent properties. Additionally, antimicrobial investigations revealed that transition metal complexes generally exhibited antimicrobial activity against both gram‐positive and gram‐negative bacterial strains compared to lanthanide metal complexes, in most cases. However, it is noteworthy that the Dy (III) complex displayed the lowest minimum inhibitory concentration and minimum biocidal concentration values of 16 μg/ml against Staphylococcus epidermidis, indicating its potential as a candidate for the treatment of this pathogenic bacterium. The main purpose of this article is to investigate the variations in the synthesis and characterization of lanthanide and transition metal complexes utilizing the same Schiff base ligand suitable for applications in the pharmaceutical industry and optical material sciences.

show abstract

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Probing the variations of synthesis, antimicrobial activity, and optical properties of new lanthanide and transition metal complexes of salicylaldehyde‐dipropylenetriamine ligand

Ebqa'ai,

Reed,

Seni

et al. 2024

Applied Organom Chemis

View full text Add to dashboard Cite

show abstract

“…A number of azomethines and their complexes possess high biological activity, including antineoplastic 8,9 and antiviral. 10 It has been recently shown that the macrocyclic Schiff bases can also recognize and selectively bind different anions acting as artificial anionic receptors. 11 Introduction of a template agent is the most reliable method to prevent oligocondensation and switch a process toward forming macrocyclic Schiff bases IV.…”

Section: Introductionmentioning

confidence: 99%

“…Some azomethine complexes possess nonlinear optical properties, whereas macrocyclic azomethines themselves can form distotic liquid crystals (see ref and references cited therein). A number of azomethines and their complexes possess high biological activity, including antineoplastic 8,9 and antiviral . It has been recently shown that the macrocyclic Schiff bases can also recognize and selectively bind different anions acting as artificial anionic receptors …”

Section: Introductionmentioning

confidence: 99%