2024
DOI: 10.3389/fchem.2024.1486933
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New reverse sum Revan indices for physicochemical and pharmacokinetic properties of anti-filovirus drugs

W. Tamilarasi,
B. J. Balamurugan

Abstract: Ebola and Marburg viruses, biosafety level 4 pathogens, cause severe hemorrhaging and organ failure with high mortality. Although some FDA-approved vaccines or therapeutics like Ervebo for Zaire Ebola virus exist, still there is a lack of effective therapeutics that cover all filoviruses, including both Ebola and Marburg viruses. Therefore, some anti-filovirus drugs such as Pinocembrin, Favipiravir, Remdesivir and others are used to manage infections. In theoretical chemistry, a chemical molecule is converted … Show more

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