The effect of the Fermi motion on nuclear structure function at large Q2 (the EMC effect) is discussed in detail. We especially study its dependences on the kinematics of interaction, the 4-momentum transfer Q2, the nucleon momentum distribution inside nucleus and the nuclear mass number. Moreover the structure function of 12C at very large x such as x>l is evaluated by only the nuclear Fermi motion, and related problems are discussed. We also point out a new dynamical mechanism expected to produce the depletion of valence quark inside nucleus for intermediate x, which does not encroach upon the conventional nuclear physics, and discuss it along the line of scaling hypothesis proposed by Dat6 et al.