New serotype of Bartonella heriselae in endocarditis and cat-scratch disease

Drancourt, Michel; Birtles, Richard J.; Raoult, Didier; Chaumentin, G.; Vandenesch, F.; Etienne, Jérôme

doi:10.1016/s0140-6736(96)90012-4

Cited by 185 publications

(126 citation statements)

References 13 publications

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“…Bartonella henselae is a re-emerging human pathogen that has been associated with BA and BP, cat scratch disease (CSD), bacteraemia and endocarditis (Drancourt et al, 1996;Anderson and Neuman, 1997). Histological investigations of biopsy specimens from patients with BA revealed bacteria in close association with proliferating endothelial cells (Schneider et al, 1993;Monteil et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

Evidence of a leading role for VEGF inBartonella henselae-induced endothelial cell proliferations

Kempf

Volkmann

Schaller

et al. 2001

Cellular Microbiology

152

184

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Section: Discussionmentioning

confidence: 99%

Evidence of a leading role for VEGF inBartonella henselae-induced endothelial cell proliferations

Kempf

Volkmann

Schaller

et al. 2001

Cellular Microbiology

152

184

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“…Bartonella henselae isolates differing in their 16S rRNA gene sequences (type I and type II) have been found infecting cats and humans [5,6,14,23,39,40]. It has been suggested that these types may differ in their pathogenicity [3,5,6,37,40].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Bartonella infection in domestic cats in Denmark

Chomel

Boulouis

Petersen³

et al. 2002

Vet. Res.

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-Whole blood and serum from 93 cats (44 pets and 49 shelter/stray cats) from Denmark were tested for the presence of feline Bartonella species by culture and for the presence of Bartonella antibodies by serology. Bartonella henselae was isolated from 21 (22.6%) cats. Bacteremia prevalence was not statistically different between shelter/stray cats (13/49, 26.5%) and pet cats (8/44, 18.2%), but varied widely by geographical origin of the cats, even after stratification for cat origin or age (p < 0.001). All isolates but one were B. henselae type II. The only cat bacteremic with B. henselae type I was not co-infected with B. henselae type II. None of the cats was harboring either B. clarridgeiae or B. koehlerae. Almost half (42/92, 45.6%) of the cats were seropositive for B. henselae and antibody prevalence was similar in shelter/stray cats (23/49, 46.9%) and pet cats (19/43, 44.2%). This is the first report of isolation of B. henselae from domestic cats in Denmark. This study also indicates that domestic cats, including pet cats, constitute a large Bartonella reservoir in Denmark. anticorps anti-Bartonella. Bartonella henselae a été isolée de 21 (22,6 %) chats. Les prévalences de bactériémie n'étaient pas significativement différentes entre les chats de fourrière ou errants (13/49 ; 26,5 %) et les chats de compagnie (8/44 ; 18,2 %), mais étaient différentes en fonction de l'origine géographique des chats, même après stratification (p < 0,001). Tous les isolats sauf un ont été identifiés comme appartenant au type II de B. henselae. Le seul chat infecté par B. henselae type I n'était pas co-infecté par B. henselae type II. Bartonella clarridgeiae et B. koehlerae n'ont été isolées d'aucun des chats. Presque la moitié (42/92 ; 45,6 %) des chats avaient des anticorps anti-B. henselae en immunofluorescence et la prévalence en anticorps était assez similaire chez les chats de fourrière ou errants (23/49 ; 46,9 %) et les chats de propriétaire (19/43 ; 44,2 %). Cette étude constitue la première mise en évidence de l'existence de Bartonella henselae chez les chats au Danemark et révèle que les chats domestiques, dont les chats de compagnie, représentent un réservoir important de Bartonelles au Danemark.Bartonella henselae / chat domestique / Felis catus / Danemark

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“…This reference strain, which is also a type I strain based on its 16S rRNA gene sequence [6,20], was isolated from the blood of an HIV positive patient [48]. The feline strain of B. henselae type I caused a different type of infection in cats than the reference B. henselae Houston I strain, by inducing fever, longer bacteremia and bacteremia relapses.…”

Section: Discussionmentioning

confidence: 99%

“…Two sero/genotypes of B. henselae were described and have been used for epidemiological and microbiological investigations [6,20,30,31,42,[53][54][55]59]. Recently, Arvand et al [4] demonstrated virulence differences between the B. henselae Berlin I strain and B. henselae Houston I, which both belong to the same genotype, despite the fact that they were indistinguishable by PFGE and 16S rRNA typing.…”

Section: Discussionmentioning

confidence: 99%

“…Cats are persistently infected with Bartonella in their bloodstream for a few months up to several years [1,35,38]. Bartonella henselae have been classified in two predominant serotypes/genotypes, type I and type II, also designated as Houston I and BA-TF/Marseille based on 16S rRNA-DNA sequencing [6,7,20,31,53,55]. Major regional variations in the prevalence of these variants have been reported in domestic cat populations.…”

Section: Introductionmentioning

confidence: 99%

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Experimental infection of specific pathogen free (SPF) cats with two different strains of Bartonella henselae type I: A comparative study

et al. 2002

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-Domestic cats are the reservoir of Bartonella henselae, the main causative agent of cat scratch disease. We compared B. henselae type I infection characteristics in 6 SPF cats infected with a feline strain (4.8 × 10 7 colony-forming units (CFU)/mL) and in 6 SPF cats infected with the reference Houston I strain (6.6 × 10 6 CFU/mL to 9.6 × 10 7 /mL). All the cats inoculated with the feline strain, but none of the cats inoculated with B. henselae Houston I, developed a fever within 2-12 days (mean: 5.8 days) post inoculation (PI), which lasted for 1-2 weeks. However, all 12 cats became bacteremic. The duration of bacteremia was significantly longer in the cats inoculated with the feline strain (mean: 237 days) than in the cats inoculated with Houston I strain (mean: 60 days) (p < 0.01). Five (83%) cats inoculated with the feline strain and none of the six cats inoculated with B. henselae Houston I had relapsing bacteremia (p = 0.02). IgG antibodies were detected by IFA within 1-2 weeks for both strains, but peaked later (week 10 versus week 3 PI) for the feline strain. By ELISA, using antigens of each B. henselae strain, all 12 cats developed Bartonella specific IgM and IgG antibodies, but the cats infected with B. henselae Houston I antigen yielded significantly lower optical density values (p < 0.05). By SDS-PAGE, PFGE and Western blotting, protein profile differences (84 to 89% homology) were observed between the two strains. If a feline vaccine is to be developed in order to prevent human infection, the choice of the vaccine strain will be critical, since major differences were identified even between strains belonging to the same sero/genotype. Résumé -Étude comparative de l'infection expérimentale de chats sans germe pathogène spécifique avec deux souches différentes de Bartonella henselae type I. Le chat domestique constitue le réservoir de Bartonella henselae, l'agent principal de la maladie des griffes du chat. Les caractéristiques de l'infection expérimentale de chats domestiques sans germe pathogène spécifique par une souche féline de B. henselae type I (6 chats recevant une dose de 4,8 × 10 7 colonies/mL) ou de la souche de référence Houston I (6 chats recevant entre 6,6 × 10 6 et 9,6 × 10 7 colonies/mL) sont présen-tées. Les six chats infectés avec la souche féline, mais aucun des six chats infectés avec la souche Houston I, développèrent de la fièvre 2 à 12 jours après l'inoculation (moyenne : 5,8 jours) et celle-ci dura entre 1 et 2 semaines. Cependant, les 12 chats devinrent bactériémiques, mais la bactériémie dura significativement plus longtemps chez les chats infectés par la souche féline (moyenne : 237 jours) que chez les chats infectés par la souche Houston I (moyenne : 60 jours) (p < 0.01). La majorité (83 %) des chats inoculés avec la souche féline présentèrent des récurrences de bactériémie, alors qu'aucun des chats inoculés avec la souche Houston I n'en présenta (p < 0.02). Les anticorps IgG, détectés par immunofluorescence chez tous les chats entre 1 et 2 semaines après l'inocula...

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New serotype of Bartonella heriselae in endocarditis and cat-scratch disease

Cited by 185 publications

References 13 publications

Evidence of a leading role for VEGF inBartonella henselae-induced endothelial cell proliferations

Evidence of a leading role for VEGF inBartonella henselae-induced endothelial cell proliferations

Prevalence of Bartonella infection in domestic cats in Denmark

Experimental infection of specific pathogen free (SPF) cats with two different strains of Bartonella henselae type I: A comparative study

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