New serum and nasal immunological biomarkers in pediatric infection caused by respiratory syncytial virus

Neto, Erasmo Assumpção; Durigon, Thomas Stravinskas; Oliveira-Júnior, Manoel Carneiro; Dias, Alana dos Santos; MacKenzie, BreAnne; Constancio, Fabiane Scandarolli; El-Mafarjeh, Elias; Rigonato‐Oliveira, Nicole Cristine; Brito, Auriléia Aparecida de; Moraes, Gabriel; Oliveira, Ana Paula Ligeiro de; Oliveira, Danielle Bruna Leal; Durigon, Edison Luiz; Vieira, Rodolfo de Paula

doi:10.1183/13993003.congress-2016.pa1277

Cited by 2 publications

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“…During an infection with hRSV, McNamara et al found that the concentration of IL-8 remains elevated during the disease, even when the number and recruitment of neutrophils ultimately decreased (110). Elevated IL-8 levels (in nasopharyngeal samples) have been widely correlated with disease severity caused by hRSV infection, including the risk of mechanical ventilation (4, 90). In 2013, Díaz et al found high IL-8 levels in NPA in children with severe hRSV bronchiolitis as compared to controls and patients with mild disease manifestations.…”

Section: Severity Prognosis In Hrsv Infectionmentioning

confidence: 99%

Cytokines in the Respiratory Airway as Biomarkers of Severity and Prognosis for Respiratory Syncytial Virus Infection: An Update

et al. 2019

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The human respiratory syncytial virus (hRSV) is one of the most important causes of upper and lower respiratory tract infections in children and the main cause of bronchiolitis worldwide. Disease manifestations caused by hRSV may vary from mild to severe, occasionally requiring admission and hospitalization in intensive care units. Despite the high morbidity rates associated to bronchiolitis, treatment options against hRSV are limited and there are no current vaccination strategies to prevent infection. Importantly, the early identification of high-risk patients can help improve disease management and prevent complications associated with hRSV infection. Recently, the characterization of pro- and anti-inflammatory cytokine patterns produced during hRSV-related inflammatory processes has allowed the identification of potential prognosis biomarkers. A suitable biomarker should allow predicting the severity of the infection in a simple and opportune manner and should ideally be obtained from non-invasive samples. Among the cytokines associated with hRSV disease severity, IL-8, interferon-alpha (IFN-alpha), and IL-6, as well as the Th2-type cytokines thymic stromal lymphopoietin (TSLP), IL-3, and IL-33 have been highlighted as molecules with prognostic value in hRSV infections. In this review, we discuss current studies that describe molecules produced by patients during hRSV infection and their potential as biomarkers to anticipate the severity of the disease caused by this virus.

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Section: Severity Prognosis In Hrsv Infectionmentioning

confidence: 99%