New, Simple and Versatile Synthesis of Protected α-Alkylidene-β-amino Acids from Activated Vinylphosphonates

Abstract

A two-step route to Boc-protected a-alkylidene-b-amino esters was developed by addition of sodium tert-butylcarbamate to ethyl 2-diethoxyphosphoryl-2-alkenoates followed by the HornerWadsworth-Emmons olefination of aldehydes using intermediate 2-diethoxyphosphoryl-3-tert-butoxycarbonylaminoalkanoates.