New stationary phase based on β-cyclodextrin for normal-phase HPLC group-separation of organic nitrates

Wossner, M.; Ballschmiter, K.

doi:10.1007/s002160050070

Cited by 10 publications

(1 citation statement)

References 2 publications

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“…Macrocyclic compounds such as crown ethers, cryptands, cyclodextrins and resorcinarenes have been introduced as effective IC exchangers in both stationary and mobile phases. [22][23][24][25][26] The resorcinarenes are a recently developed class of macrocyclic compounds used as ion exchangers and our previous research on resorcinarene stationary phases confirms their usefulness as separators in IC systems. 25,[27][28][29][30] Synthesizing these compounds with long alkyl chains facilitates their adherence to the packing resin.…”

Section: Introductionmentioning

confidence: 84%

A new approach for trace analysis of guanidine compounds in surface water with resorcinarene-based ion chromatography columns

Panahi

Weaver

Lamb

et al. 2016

Analyst

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Trace levels of pharmaceuticals have been detected in surface water and may pose a health risk to humans and other organisms. New chromatographic materials will help identify and quantify these contaminants. We introduce a new ion chromatographic (IC) material designed to separate cationic pharmaceuticals and report its ability to separate a group of guanidine compounds. Guanidine moieties are strongly basic and protonated under acid conditions, and therefore can potentially be separated on the newly designed stationary phase and detected by ion exchange chromatography. The new column packing material is based on glutamic acids bonded to resorcinarene moieties that in turn are bound to divinylbenzene macroporous resin. Detection limits in the range of 5-30 μg L(-1) were achieved using integrated pulsed amperometric detection (IPAD) for guanidine (G), methylguanidine (MG), 1,1-dimethylbiguanide (DMG), agmatine (AGM), guanidinobenzoic acid (GBA) and cimetidine (CIM). Suppressed conductivity (CD) and UV-vis detection resulted in limits of detection similar to IPAD, in the range of 2-66 μg L(-1), but were not able to detect all of the analytes. Three water sources, river, lake, and marsh, were analyzed and despite matrix effects, sensitivity for guanidine compounds was in the 100 μg L(-1) range and apparent recoveries were 80-96%. The peak area precision was 0.01-2.89% for IPAD, CD and UV-vis detection.

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Section: Introductionmentioning

confidence: 84%

A new approach for trace analysis of guanidine compounds in surface water with resorcinarene-based ion chromatography columns

Panahi

Weaver

Lamb

et al. 2016

Analyst

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Ion Chromatography and Membrane Separations Using Macrocyclic Ligands

Lamb

2012

Supramolecular Chemistry

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The selectivity of macrocyclic ligand hosts in binding ionic and neutral guests was recognized early and has been applied to separations science in a number of ways. Prominent among these applications are ion chromatography (IC) and liquid membranes. This chapter summarizes the various ways by which macrocyclic ligands have been incorporated into these two separations techniques. It begins with a description of the intrinsic selectivities of the macrocyclic hosts used in these applications to date. The next section describes the basic elements of IC and the chemical features of standard ion chromatographic separations. It then proceeds to describe how macrocycles such as crown ethers, cryptands, resorcinarenes, and others have been incorporated into both the mobile and stationary phases of ion chromatographic systems to effect novel separations of both cations and anions. The development of capacity gradient chromatography of anions, unique to macrocycle‐based IC, is described. The application to both analytical separations and preconcentration/matrix elimination is also included. The next section introduces the various types of liquid membranes, including bulk liquid membranes, solid supported liquid membranes, emulsion liquid membranes, and polymer inclusion membranes. This section then proceeds to describe the various studies conducted to characterize the use of macrocyclic ligands as selective carriers of cations, anions, and neutral species across these membranes for separations purposes.

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Gradient elution of organic acids on a β-cyclodextrin column in the polar organic mode and its application to drug discovery

Simms¹,

Jeffries²,

Zhao³

et al. 2004

Journal of Chromatography A

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New stationary phase based on β-cyclodextrin for normal-phase HPLC group-separation of organic nitrates

Cited by 10 publications

References 2 publications

A new approach for trace analysis of guanidine compounds in surface water with resorcinarene-based ion chromatography columns

A new approach for trace analysis of guanidine compounds in surface water with resorcinarene-based ion chromatography columns

Ion Chromatography and Membrane Separations Using Macrocyclic Ligands

Gradient elution of organic acids on a β-cyclodextrin column in the polar organic mode and its application to drug discovery

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