New studies with stable gastric pentadecapeptide protecting gastrointestinal tract. significance of counteraction of vascular and multiorgan failure of occlusion/occlusion-like syndrome in cytoprotection/organoprotection

Sikiric, Predrag; Sever, Marko; Krezic, Ivan; Vranes, Hrvoje; Kalogjera, Luka; Smoday, Ivan Maria; Vukovic, Vlasta; Oroz, Katarina; Coric, Luka; Skoro, Marija; Kavelj, Ivana; Zubcic, Slavica; Sikiric, Suncana; Beketic Oreskovic, Lidija; Oreskovic, Ivana; Blagaic, Vladimir; Brcic, Klara; Strbe, Sanja; Staresinic, Mario; Boban Blagaic, Alenka; Skrtic, Anita; Seiwerth, Sven

doi:10.1007/s10787-024-01499-8

Inflammopharmacol

2024

DOI: 10.1007/s10787-024-01499-8

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New studies with stable gastric pentadecapeptide protecting gastrointestinal tract. significance of counteraction of vascular and multiorgan failure of occlusion/occlusion-like syndrome in cytoprotection/organoprotection

Predrag Sikiric,

Marko Sever,

Ivan Krezic

et al.

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Stable Gastric Pentadecapeptide BPC 157 and Intestinal Anastomoses Therapy in Rats—A Review

Bajramagic,

Sever,

Rasic

et al. 2024

Pharmaceuticals

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By introducing the healing of many distinctive anastomoses by BPC 157 therapy, this review practically deals with the concept of the resection and reconnection of the hollow parts of the gastrointestinal tract as one of the cornerstones of visceral surgery. In principle, the healing of quite distinctive anastomoses itself speaks for applied BPC 157 therapy, in particular, as a way in which the therapy of anastomoses can be successfully approached and carried out. Some of the anastomoses implicated were esophagogastric, colocolonic, jejunoileal, and ileoileal anastomoses, along with concomitant disturbances, such as esophagitis, sphincter dysfunction, failed intestinal adaptation, colitis, short bowel syndrome, major vessel occlusion, NO-system, and prostaglandins-system dysfunction, which were accordingly counteracted as well, and, finally, findings concerning other anastomoses healing (i.e., nerve and vessel). Moreover, the healing of fistulas, both external and internal, colocutaneous, gastrocutaneous, esophagocutaneous, duodenocutaneous, vesicovaginal, colovesical, and rectovaginal in rats, perceived as anastomoses made between two different tissues which are normally not connected, may also be indicative. This may be a particular reconnection of the parts of the gastrointestinal tract to re-establish adequate integrity depending on the tissue involved, given that both various intestinal anastomoses and various fistulas (intestinal and skin were accordingly healed simultaneously as the fistulas disappeared) were all healed.

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Stable Gastric Pentadecapeptide BPC 157 and Intestinal Anastomoses Therapy in Rats—A Review

Bajramagic,

Sever,

Rasic

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

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New studies with stable gastric pentadecapeptide protecting gastrointestinal tract. significance of counteraction of vascular and multiorgan failure of occlusion/occlusion-like syndrome in cytoprotection/organoprotection

Cited by 1 publication

References 172 publications

Stable Gastric Pentadecapeptide BPC 157 and Intestinal Anastomoses Therapy in Rats—A Review

Stable Gastric Pentadecapeptide BPC 157 and Intestinal Anastomoses Therapy in Rats—A Review

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