New Surface-Enhanced Raman Sensing Chip Designed for On-Site Detection of Active Ricin in Complex Matrices Based on Specific Depurination

Tang, Jijun; Sun, Jingbo; Lui, Rui; Zhang, Zongmian; Liu, Rui; Xie, Jianwei

doi:10.1021/acsami.5b12860

Cited by 28 publications

(30 citation statements)

References 40 publications

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“…Tang et al developed a simple and reproducible SERS chip for highly sensitive and selective screening of active ricin in complex matrices. 69 They fabricated single strand oligodeoxynucleotides modified AuNPs in order to amplify recognition and reaction by virtue of their cooperative binding property. To improve sensitivity of this method, a Ag nanoshell was deposited on post-reacted poly (21dA)-AuNPs, which lowered LOD to 8.9 ng mL…”

Section: Biomolecules (Dna Protein and Cell)mentioning

confidence: 99%

Applications of gold nanoparticles in medicine and therapy

Madkour¹

2018

PPIJ

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The stability and dispersity of AuNMs in solution play a key role for the many applications. Most inorganic nanomaterials are not well dispersed in physiological buffers and require function-alization by thiols or surfactants to offer the stabilization forces. Furthermore, sufficient blood circulation time is critical for both imaging and in vivo drug delivery. Localized surface Plasmon resonance (LSPR) is one of the most significant features of AuNMs. The AuNMs as reporters have been broadly applied into lateral flow immunechromatographicalassay (LFICA) and enzyme-linked immunosorbent assay (ELISA), which is a well-established technology for analysis of the target analytes in food safety, clinical diagnosis, environmental monitoring, and medical science and so on. Au based nanomaterials (AuNMs) are known to possess many attractive features such as unique electrical, optical and catalytic properties as well as excellent biocompatibility. In this review, we summarize the current advancement on application of AuNMs in analytical sciences based on their local surface plasmon resonance, fluorescence and electrochemistry properties. AuNMs based imaging and therapy in biomolecules is explained. As one of the most reliable imaging modes, computed tomography (CT), X-ray and SERS imaging has been widely used owing to its high spatial and density resolution. We end the review by a discussion of the conjugation between gold nanoparticles with other kinds of nanoparticles such as other metals and carbon nano structures. Finally, future development in this research area is also prospected.

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Section: Biomolecules (Dna Protein and Cell)mentioning

confidence: 99%

Applications of gold nanoparticles in medicine and therapy

Madkour¹

2018

PPIJ

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“…Compared to conventional detecting methods such as those based on PCR, the method was demonstrated to be rapid, facile and very sensitive. Tang et al developed a simple and reproducible SERS chip for highly sensitive and selective screening of active ricin in complex matrices [63]. They fabricated single strand oligodeoxynucleotides modified AuNPs in order to amplify recognition and reaction by virtue of their cooperative binding property.…”

Section: Biomoleculesmentioning

confidence: 99%

Advanced AuNMs as nanomedicine’s central goals capable of active targeting in both imaging and therapy in biomolecules

Lh¹

2017

Glob Drugs Therap

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“…However, some indicator preparations or detection operations are usually too complicated in designing and to perform. Receiving of some signals requires devices sometimes . In particular, most fluorescent probes need to be excited by extra operations when in use.…”

Section: Introductionmentioning

confidence: 99%

Facile On‐Site Detection Based on Reactional Wettability Variation

Lin

Zheng

Chen

et al. 2018

Adv Materials Inter

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A new on‐site detection strategy is developed based on reactional wettability variation (RWV), which is induced by the coordination reaction between azoimidazole (AzoIm) ligands on an electrospun polymer membrane and the analytes. A sensor unit is fabricated by implanting photoresponsive AzoIm ligands on an electrospun polymer membrane. Contact angle of analyte solution droplets on the membrane surface is varied by coordination reaction between ligands and analytes. The response variation of each analyte is influenced by the membrane‐forming polymer and the conformation of AzoIm. Based on these two factors, the sensor is expanded into a sensor array to offer on‐site detection. The principle component analysis is further applied to evaluate the detection performance and influential structural factors of the array on those ions. The differential response it works on results from varied binding constants of ion–AzoIm complexes and pH of the analyte solutions. Moreover, the detection of metal ions is extended to the bioinorganic molecule of hemin in the same mechanism. It is envisioned that the application of the RWV general pattern can open new possibilities for detection.

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New Surface-Enhanced Raman Sensing Chip Designed for On-Site Detection of Active Ricin in Complex Matrices Based on Specific Depurination

Cited by 28 publications

References 40 publications

Applications of gold nanoparticles in medicine and therapy

Applications of gold nanoparticles in medicine and therapy

Advanced AuNMs as nanomedicine’s central goals capable of active targeting in both imaging and therapy in biomolecules

Facile On‐Site Detection Based on Reactional Wettability Variation

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