New Syntheses and Potential Antimalarial Activities of New “Retinoid‐Like Chalcones”.

Abstract

Vitamins U 0900New Syntheses and Potential Antimalarial Activities of New "Retinoid-Like Chalcones". -A series of retinoid-like chalcones is synthesized starting from new enaminone synthons (I). The 4-hydroxy-chalcone-like compound (XI) exhibits a good and reproducible inhibitory effect on the in vitro culture of Plasmodium falciparum. -(VALLA*, A.; VALLA, B.; CARTIER, D.; LE GUILLOU, R.; LABIA, R.; FLORENT, L.; CHARNEAU, S.; SCHREVEL, J.; POTIER, P.; Eur.

Modified quaternary ammonium salts as potential antimalarial agents

“…Solid samples were mixed in a mortar with KBr (1:100) and pressed in a hydraulic press (14 tons) to small tablets, while for liquid samples one drop was placed between two plates of sodium chloride. The 1 H and 13 …”

“…The organic layer was dried under Na 2 SO 4 , filtered, evaporated under reduced pressure and the residue was purified by column chromatography (silica gel) using a mixture of AcOEt/MeOH (8:2) as eluent. 13 13 13 …”

“…28 (m, 5H, H arom ); 6.13-6.08 (m, 4H, @CH); 5.73-5.65 (m, 2H, H 2 , H 7 ); 3.54 (s, 2H, CH 2 Ph); 3.09 (t, 2H, J = 6.6 Hz, H 8 ); 2.40 (t, 2H, J = 7.0 Hz, NCH 2 ); 1.77 (d, 3H, J = 6.6 Hz, CH 3 CH@); 1.46 (q, 2H, NCH 2 CH 2 ); 1.25 (m, 22H, CH 2 ); 0.88 (t, 3H, J = 6.2 Hz, CH 3 ). 13 …”

“…13 Moreover, it is also reported the high antiplasmodial activity of a marine carotenoid, fucoxanthin, extracted from marine brown seaweeds, macroalgae, diatoms and microalgae which activity could be related to its antioxidant properties. 14 In the last decade our interest was turned on the synthesis of polyunsaturated molecules 15,16 whose structure is shown in Figure 1 which share with carotenoids and retinoids some structural features, antioxidant properties, effects on cell proliferation and antibacterial activity.…”

Antihyperglycemic activity of naphthylchalcones

“…Chalcones are compounds previously formed in natural synthesis of flavonoids in plants and are known to exhibit several biological activities such as apoptosis induction, an anti-proliferative action in various cancer cell types, inhibition of pro-inflammatory mediators, antiplatelet activity, potential antimalarial activity, among others [1][2][3][4][5][6][7]. It is well known that different substituents at different positions on the core structure of chalcones ( Fig.…”