New Taxane Diterpenoids from Taiwanese Taxus sumatrana

Shen, Ya‐Ching; Pan, Yu-Ling; Lo, Kuang‐Liang; Wang, Shih-Sheng; Chang, Yao-To; Wang, Li-Tang; Lin, Yu‐Chi

doi:10.1248/cpb.51.867

Cited by 14 publications

(8 citation statements)

References 17 publications

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“….mangostana extracts were also used as tonic for various ailments [26,43] particularly as antimicrobial agent [22,23], antidiabetic, gastrointestinal health [4] etc. Based on these reports some products were also developed and sold in the market with a claim of health beneficial properties [1].…”

Section: Similarly We Attempted To Determine the Contribution Of Varimentioning

confidence: 99%

“…G. mangostana (MS) fruit juice has become a major dietary supplement, and was ranked as one of the top selling "botanicals" on the market in 2005 [18]. Xanthone derivatives as the major secondary metabolites of G. mangostana fruits [19][20][21], exhibit antibacterial [22,23], antifungal [24], anti-inflammatory [25], antioxidant [26,6], antiplasmodial [20] and cytotoxic activities [27,28]. The most abundant xanthone from G. mangostana, -mangostin was found to inhibit alveolar duct formation in mouse mammary organ culture model and to suppress the carcinogen induced formation of aberrant crypt foci in a short-term colon carcinogenesis model [26,29].…”

Section: Introductionmentioning

confidence: 99%

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Health and Wellness Product from Mangosteen (Garcinia mangostana L.) Rind: Bioactive Potentials

Shashirekha

Shylaja

Shivaleela

et al. 2014

Int. J. Biotech. Well. Indus.

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Mangosteen rind (MSR) (Garcinia mangostana L.) is a predominant component of the fruit contributing to 62% of the whole fruit. However, utilization of the same for the preparation of health products was not explored due to its sensorially less acceptable parameters. Differential extraction in different polarity solvents of MSR was done and evaluated their acceptability for product preparation. Current study thus is a detailed investigation on bioactivity profiling of MSR fraction and utilization of the same for health product preparation. Among various extracts, 70% ethanol (70%AE) yielded the maximum (15g/100g). Xanthone:Phenolic ratio was 1: 2.8, in 70%AE as opposed to hot water extract-HWE and 50% AE, which contained Xanthone:Phenolic ratio of 1:1.4/5. Higher the phenolic content obviously reduces the bitterness of Xanthones. 70% AE contained phenolics 60.08± 0.213 mg/g and xanthones 22.56± 0.317 mg/g. HPLC analysis revealed a spectrum of phenolic acids such as gallic, chlorogenic, caffeic, epicatechin, catechin and ferulic acids at various levels. Potent Free Radical Scavenging (FRS) activity, cytoprotectivity, DNA protectivity, H + K + ATPase inhibitory (PPAI) activities were observed in 70% AE. Gallic/tannic acid appear to contribute to antioxidant activity; while ferulic acid was responsible for PPAI activity in 70%AE. Among xanthones, although-mangostin was the dominating component, gartanin, 8 deoxygartanin and 3-isomangostin contributed to FRS activity. The products were prepared from 70%AE which are sensorially acceptable. Data thus for the first time delineate the specific health beneficial role of both phenolic and xanthone constituents in MSR particularly with higher abundance of phenolics than xanthones.

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Section: Similarly We Attempted To Determine the Contribution Of Varimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Health and Wellness Product from Mangosteen (Garcinia mangostana L.) Rind: Bioactive Potentials

Shashirekha

Shylaja

Shivaleela

et al. 2014

Int. J. Biotech. Well. Indus.

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“…There were two deaths caused by Taxus sumatrana (Miq.) de Laub., which results in sinus bradycardia, premature ventricular contractions, atrioventricular conduction defects, or ventricular tachydysrhythmias (5,(35)(36)(37)(38). In the two Taxus fatalities, one died from hemolysis and multiple organ failure and the other from acute myocardial infarction.…”

Section: Sodium Channel Agonists Aconitum Carmichaelimentioning

confidence: 99%