2013
DOI: 10.6026/97320630009656
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New tools for the investigations of Neuro-AIDS at a molecular level: The potential role of data-mining

Abstract: Cognitive impairment represents the most significant and devastating neurological complication associated with HIV infection. Despite recent advances in our knowledge of the clinical features, pathogenesis, and molecular aspects of HIV-related dementia, current diagnostic strategies are associated with significant limitations. It has been suggested that the use of some biomarkers may assist researchers and clinicians in predicting the onset of the disease process and in evaluating the effects of new therapies.… Show more

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Cited by 4 publications
(2 citation statements)
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“…Multiple pathogenic mechanisms participate to HIVrelated neurodegeneration [1][2][3][14][15][16]; HIV replication accounts for a minor part of neurodegeneration, as brain HIV replicates mainly in perivascular macrophages and microglia, while it is generally restricted in astrocytes [11]. We observed abortive HIV infection of astrocytes, but sufficient to activate MSRV and Syncytin-1 (Fig.…”
Section: Discussionmentioning
confidence: 69%
See 1 more Smart Citation
“…Multiple pathogenic mechanisms participate to HIVrelated neurodegeneration [1][2][3][14][15][16]; HIV replication accounts for a minor part of neurodegeneration, as brain HIV replicates mainly in perivascular macrophages and microglia, while it is generally restricted in astrocytes [11]. We observed abortive HIV infection of astrocytes, but sufficient to activate MSRV and Syncytin-1 (Fig.…”
Section: Discussionmentioning
confidence: 69%
“…The pathogenic mechanisms of HIV-related neurodegeneration are not fully elucidated and include both host and viral mechanisms [14][15][16]. The neurotoxic effects of HIV are direct and indirect, mostly mediated by its gp120 and Tat proteins, through induction of apoptosis, microRNA dysregulation, alterations of mytocondria and of intracellular-signalling pathways, as reviewed in [17].…”
mentioning
confidence: 99%