New Treatment Modalities for Brain Tumors in Dogs and Cats

Rossmeisl, John H.

doi:10.1016/j.cvsm.2014.07.003

Cited by 27 publications

(57 citation statements)

References 123 publications

(276 reference statements)

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“…In our study, dogs with meningiomas treated with SRA had a median ST of 422 days, which compares favorably to previously published median ST after standard surgical resection, which have typically ranged from 180 to 210 days (Kostolich et al, 1987;Niebauer et al, 1991;Axlund et al, 2002;Bilderback et al, 2006;Rossmeisl, 2014). In addition, we report ST for 14 gliomas treated with SRA, with a median survival of 66 days, which is slightly longer than previously reported with palliative treatment (Adams et al, 2005).…”

Section: Discussionsupporting

confidence: 78%

“…In general, rostrontentorial tumors have been reported to have a better prognosis than infratentorial neoplasms (Dickinson, 2014). Focusing on meningiomas, the available literature has reported median ST of 180-210 days after SRA (Kostolich et al, 1987;Niebauer et al, 1991;Axlund et al, 2002;Bilderback et al, 2006;Rossmeisl, 2014). However, dogs with meningiomas treated with SRA in this study achieved a longer median ST (median, 422 days; mean, 731 days).…”

Section: Discussioncontrasting

confidence: 49%

“…Neurosurgical treatment using devices such as intracranial endoscopy or ultrasonic surgical aspirator, which either improve intraoperative visualization or facilitate tumor excision, have been associated with longer median ST after surgical resection for intracranial meningiomas, with ST ranging from 1260 to 2100 days. (Greco et al, 2006;Klopp and Rao, 2009;Rossmeisl, 2014). Currently, no meaningful conclusions can be made from published data relating to surgery of intraaxial tumors (Dickinson, 2014) and, to the best of the authors' knowledge, a retrospective or prospective paper looking for ST for gliomas treated with surgical resection alone (SRA) has not been previously reported.…”

Section: Introductionmentioning

confidence: 74%

“…Radiation therapy has become a mainstay of treatment for intracranial neoplasia in both human and veterinary patients, either as a primary or adjunctive treatment (Dickinson, 2014). Radiotherapy has demonstrated to improve ST in presumptive and confirmed meningiomas, with ST ranging from 240 to 577 days (Turrel et al, 1984;Evans et al, 1993;Axlund et al, 2002;Bley et al, 2005;Griffin et al, 2014;Rossmeisl, 2014). Radiation therapy has been reported to be beneficial when compared to SRA for the treatment of meningiomas (Axlund et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Most published information is related to more easily accessible canine and feline meningiomas, with only anecdotal data for other tumor types such as gliomas (Dickinson, 2014). Surgical excision alone for canine meningiomas resulted in median ST of 180-210 days (Kostolich and Dulisch, 1987;Niebauer and Dayrell-Hart, 1991;Axlund et al, 2002;Bilderback et al, 2006;Rossmeisl, 2014). Neurosurgical treatment using devices such as intracranial endoscopy or ultrasonic surgical aspirator, which either improve intraoperative visualization or facilitate tumor excision, have been associated with longer median ST after surgical resection for intracranial meningiomas, with ST ranging from 1260 to 2100 days.…”

Section: Introductionmentioning

confidence: 99%

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Long-term follow-up of surgical resection alone for primary intracranial rostrotentorial tumors in dogs: 29 cases (2002-2013)

Suñol¹,

Mascort²,

Font³

et al. 2018

Open Vet J.

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Intracranial neoplasia is frequently encountered in dogs. After a presumptive diagnosis of intracranial neoplasia is established based on history, clinical signs and advanced imaging characteristics, the decision to treat and which treatment to choose must be considered. The objective of this study is to report survival times (ST) for dogs with intracranial meningiomas and gliomas treated with surgical resection alone (SRA), to identify potential prognostic factors affecting survival, and to compare the results with the available literature. Medical records of 29 dogs with histopathologic confirmation of intracranial meningiomas and gliomas treated with SRA were retrospectively reviewed. For each dog, signalment, clinical signs, imaging findings, type of surgery, treatment, histological evaluation, and ST were obtained. Twenty-nine dogs with a histological diagnosis who survived >7 days after surgery were included. There were 15 (52%) meningiomas and 14 (48%) gliomas. All tumors had a rostrotentorial location. At the time of the statistical analysis, only two dogs were alive. Median ST for meningiomas was 422 days (mean, 731 days; range, 10-2735 days). Median ST for gliomas was 66 days (mean, 117 days; range, 10-730 days). KaplanMeier analysis indicated that ST was significantly longer for meningiomas than for gliomas (P<0.05). A negative correlation between the presence of a midline shift and ST (P=0.037) and ventricular compression and ST (P=0.038) was observed for meningiomas. For gliomas, there were no significant associations between ST and any of the variables evaluated. In conclusion, the results of this study suggest that, for dogs that survived >7 days postoperatively, SRA might be an appropriate treatment, particularly for meningiomas, when radiation therapy is not readily available. Also, the presence of midline shift and ventricular compression might be negative prognostic factors for dogs with meningiomas.

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Section: Discussionsupporting

confidence: 78%

Section: Discussioncontrasting

confidence: 49%

Section: Introductionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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