New triazole-based coordination complexes as antitumor agents against triple negative breast cancer MDA-MB-468 cell line

Draoui, Youssef; Radi, Smaail; Bahjou, Yousra; Idir, Abderrazak; El Mahdaoui, Amal; Zyad, Abdelmajid; Miras, Haralampos N.; Ferbinteanu, Marilena; Rotaru, Aurelian; Garcia, Yann

doi:10.1039/d3ra07714d

RSC Adv.

2023

DOI: 10.1039/d3ra07714d

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New triazole-based coordination complexes as antitumor agents against triple negative breast cancer MDA-MB-468 cell line

Youssef Draoui,

Smaail Radi,

Yousra Bahjou

et al.

Abstract: The synthesis of a new family of seven new coordination complexes, with remarkable cytotoxicity and high selectivity index towards cancer cells when compared to peripheral blood mononuclear cells (PBMCs) is reported.

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2024

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Design, Synthesis, Anti‐Proliferative, and Apoptotic Assessment of Spirocyclopropyl Oxindole–Isatin Hybrids on Triple‐Negative Breast Cancer

Preeti,

Raza,

Sharma

et al. 2024

Chemistry & Biodiversity

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A series of 1H‐1,2,3‐triazole‐tethered spirocyclopropyl oxindole‐isatin hybrids were synthesized using a copper‐promoted click reaction and evaluated for their anti‐proliferative activities against triple‐negative breast cancer cell lines. The most potent compound in the series outperformed tamoxifen and 5‐fluorouracil, with selectivity indices (SI) of 1.60 and 1.99 against MDA‐MB‐468 and MDA‐MB‐231 cancer cells, respectively. The Caspase 3/7 7‐AAD assay showed live cell populations of 72.10% and 49.20% after 24 and 48 hours, respectively, indicating that the cytotoxic effect is mediated through the caspase apoptotic pathway. Molecular docking studies further suggested the compound's potential as an EGFR inhibitor, highlighting its promise as a therapeutic agent.

show abstract

Design, Synthesis, Anti‐Proliferative, and Apoptotic Assessment of Spirocyclopropyl Oxindole–Isatin Hybrids on Triple‐Negative Breast Cancer

Preeti,

Raza,

Sharma

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

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New triazole-based coordination complexes as antitumor agents against triple negative breast cancer MDA-MB-468 cell line

Abstract: The synthesis of a new family of seven new coordination complexes, with remarkable cytotoxicity and high selectivity index towards cancer cells when compared to peripheral blood mononuclear cells (PBMCs) is reported.

Cited by 1 publication

References 51 publications

Design, Synthesis, Anti‐Proliferative, and Apoptotic Assessment of Spirocyclopropyl Oxindole–Isatin Hybrids on Triple‐Negative Breast Cancer

Design, Synthesis, Anti‐Proliferative, and Apoptotic Assessment of Spirocyclopropyl Oxindole–Isatin Hybrids on Triple‐Negative Breast Cancer

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